Search Results - "Canat, X."

Activation of mitogen-activated protein kinases by stimulation of the central cannabinoid receptor CB1 by Bouaboula, M, Poinot-Chazel, C, Bourrié, B, Canat, X, Calandra, B, Rinaldi-Carmona, M, Le Fur, G, Casellas, P

“…The G-protein-coupled central cannabinoid receptor (CB1) has been shown to be functionally associated with several biological responses including inhibition of…”
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Involvement of Peripheral Benzodiazepine Receptors in the Protection of Hematopoietic Cells Against Oxygen Radical Damage by Carayon, P., Portier, M., Dussossoy, D., Bord, A., Petitprêtre, G., Canat, X., Fur, G.Le, Casellas, P.

“…Several putative functions have been attributed to the peripheral benzodiazepine receptor (PBR), but its precise physiologic role has not been elucidated. In…”
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Subcellular localization of peripheral benzodiazepine receptors on human leukocytes by Cahard, D, Canat, X, Carayon, P, Roque, C, Casellas, P, Le Fur, G

“…The peripheral-type benzodiazepine receptor (PBR) was initially identified in many peripheral tissues and in some blood cells. Drugs that bind with high…”
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A selective inverse agonist for central cannabinoid receptor inhibits mitogen-activated protein kinase activation stimulated by insulin or insulin-like growth factor 1. Evidence for a new model of receptor/ligand interactions by Bouaboula, M, Perrachon, S, Milligan, L, Canat, X, Rinaldi-Carmona, M, Portier, M, Barth, F, Calandra, B, Pecceu, F, Lupker, J, Maffrand, J P, Le Fur, G, Casellas, P

“…In the present study, we showed that Chinese hamster ovary (CHO) cells transfected with human central cannabinoid receptor (CB1) exhibit high constitutive…”
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Optimal Elimination of Leukemic T Cells From Human Bone Marrow With T101-Ricin A-Chain Immunotoxin by Casellas, Pierre, Canat, Xavier, Fauser, Axel A., Gros, Olivier, Laurent, Guy, Poncelet, Philippe, Jansen, Franz K.

“…In view of bone marrow purging before autologous transplantation in T cell malignancies, an anti-human T cell immunotoxin (IT) has been prepared by coupling…”
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Determination of sensitivity of fresh leukemia cells to immunotoxins by LAURENT, G, KUHLEIN, E, CASELLAS, P, CANAT, X, CARAYON, P, PONCELET, P, CORRELL, S, RIGAL, F, JANSEN, F. K

“…In clinical practice, sensitivity of malignant cells to a given immunotoxin remains hypothetical, since standard test systems such as the protein synthesis…”
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Development of a monoclonal antibody to immuno‐cytochemical analysis of the cellular localization of the peripheral benzodiazepine receptor by Dussossoy, D., Carayon, P., Feraut, D., Belugou, S., Combes, T., Canat, X., Vidal, H., Casellas, P.

“…Based on the amino acid sequence deduced from the cloned human peripheral benzodiazepine receptor (PBR) gene, monoclonal antibody (Mab 8D7) was produced…”
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Signaling pathway associated with stimulation of CB2 peripheral cannabinoid receptor. Involvement of both mitogen-activated protein kinase and induction of Krox-24 expression by Bouaboula, M, Poinot-Chazel, C, Marchand, J, Canat, X, Bourrié, B, Rinaldi-Carmona, M, Calandra, B, Le Fur, G, Casellas, P

“…Cannabinoids, known for their psychoactive effects, also possess immunomodulatory properties. The recent isolation and cloning of the G-protein-coupled…”
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Distribution profile and properties of peripheral-type benzodiazepine receptors on human hemopoietic cells by Canat, X, Carayon, P, Bouaboula, M, Cahard, D, Shire, D, Roque, C, Le Fur, G, Casellas, P

“…The cellular localization of peripheral-type benzodiazepine receptors (PBRs) was characterized in several human blood cell subpopulations including…”
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Immunopharmacological profile of SR 31747: in vitro and in vivo studies on humoral and cellular responses by Casellas, P, Bourrié, B, Canat, X, Carayon, P, Buisson, I, Paul, R, Brelière, J C, Le Fur, G

“…In our preceding paper, we demonstrated that both human and rat lymphocytes possess saturable high-affinity binding sites for the new sigma ligand SR 31747…”
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Role of peripheral benzodiazepine receptors in the protection of hematopoietic cells from apoptosis by Casellas, P., Carayon, P., Portier, M., Dussossoy, D., Bord, A., Penarier, G., Canat, X., Le Fur, G.

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Peripheral benzodiazepine receptor modulation with phagocyte differentiation by Canat, X, Guillaumont, A, Bouaboula, M, Poinot-Chazel, C, Derocq, J M, Carayon, P, LeFur, G, Casellas, P

“…Peripheral benzodiazepine receptor (PBR) was found to be less expressed in the immature phagocytic HL-60 and U-937 cell lines than in the more mature monocytic…”
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Allosteric modulation of peripheral sigma binding sites by a new selective ligand: SR 31747 by Paul, R, Lavastre, S, Floutard, D, Floutard, R, Canat, X, Casellas, P, Le Fur, G, Brelière, J C

“…The interactions of a new compound SR 31747 with sigma sites were examined in rat spleen membranes and in human peripheral blood leukocytes (PBL). Nanomolar…”
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Optimal elimination of leukemic T cells from human bone marrow with T101-ricin A-chain immunotoxin by Casellas, P, Canat, X, Fauser, AA, Gros, O, Laurent, G, Poncelet, P, Jansen, FK

“…In view of bone marrow purging before autologous transplantation in T cell malignancies, an anti-human T cell immunotoxin (IT) has been prepared by coupling…”
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