Search Results - "Canalis, E."

Notch in skeletal physiology and disease by Canalis, E.

“…Notch (Notch1 through 4) are transmembrane receptors that play a fundamental role in cell differentiation and function. Notch receptors are activated following…”
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Correction to: Notch in skeletal physiology and disease by Canalis, E.

“…Table 2 of the original article was incorrect. The correct table is shown below…”
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Glucocorticoid-induced osteoporosis : pathophysiology and therapy by CANALIS, E, MAZZIOTTI, G, GIUSTINA, A, BILEZIKIAN, J. P

“…Glucocorticoid-induced osteoporosis (GIO) is the most common form of secondary osteoporosis. Fractures, which are often asymptomatic, may occur in as many as…”
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Interleukin 6 mediates selected effects of Notch in chondrocytes by Zanotti, S, Canalis, E

“…Summary Objective Notch receptors determine cell fate by regulating transcription, an event mediated by the Notch intracellular domain (NICD), which is…”
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Mice harboring a Hajdu Cheney Syndrome mutation are sensitized to osteoarthritis by Zanotti, S., Yu, J., Bridgewater, D., Wolf, J.M., Canalis, E.

“…Osteoarthritis is a joint disease characterized by cartilage degradation, altered gene expression and inflammation. NOTCH1 and NOTCH2 receptors and the JAGGED1…”
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New understanding and treatments for osteoporosis by Mazziotti, G., Bilezikian, J., Canalis, E., Cocchi, D., Giustina, A.

“…To summarize promising areas of investigation in osteoporosis and to stimulate further research in this area, as discussed in a recent international…”
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Induction of a NOTCH3 Lehman syndrome mutation in osteocytes causes osteopenia in male C57BL/6J mice by Canalis, E, Yee, S P, Economides, A N, Schilling, L, Yu, J

“…Lateral Meningocele or Lehman Syndrome (LMS) is associated with NOTCH3 mutations causing deletions of the PEST domain and a gain-of-NOTCH3 function. We…”
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Role of nuclear factor of activated T cells in chondrogenesis osteogenesis and osteochondroma formation by Canalis, E., Schilling, L., Eller, T., Yu, J.

“…Purpose Nuclear factor of activated T cells (NFATc) are transcription factors that play a function in the immune response and in osteoclast differentiation. In…”
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Glucocorticoid-induced osteoporosis: an update by Mazziotti, Gherardo, Angeli, Alberto, Bilezikian, John P., Canalis, Ernesto, Giustina, Andrea

“…Glucocorticoid-induced osteoporosis occurs in two phases: a rapid, early phase in which bone mineral density is reduced, possibly as a result of excessive bone…”
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Role of Notch signaling in osteoblast differentiation and bone remodeling by Canalis, E

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Gender-Specific Changes in Bone Turnover and Skeletal Architecture in Igfbp-2-Null Mice by DeMambro, V. E, Clemmons, D. R, Horton, L. G, Bouxsein, M. L, Wood, T. L, Beamer, W. G, Canalis, E, Rosen, C. J

“…IGF-binding protein-2 (IGFBP-2) is a 36-kDa protein that binds to the IGFs with high affinity. To determine its role in bone turnover, we compared Igfbp2−/−…”
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Glucocorticoid-induced osteoporosis: summary of a workshop by Canalis, E, Giustina, A

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Osteopenia and decreased bone formation in osteonectin-deficient mice by Delany, A M, Amling, M, Priemel, M, Howe, C, Baron, R, Canalis, E

“…Bone continuously remodels in response to mechanical and physiological stresses, allowing vertebrates to renew bone as adults. Bone remodeling consists of the…”
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Skeletal Overexpression of Noggin Results in Osteopenia and Reduced Bone Formation by Devlin, R. D, Du, Z, Pereira, R. C, Kimble, R. B, Economides, A. N, Jorgetti, V, Canalis, E

“…Skeletal cells synthesize bone morphogenetic proteins (BMPs) and BMP antagonists. Noggin is a glycoprotein that binds BMPs selectively and antagonizes BMP…”
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Directing the expression of a green fluorescent protein transgene in differentiated osteoblasts: comparison between rat type I collagen and rat osteocalcin promoters by Kalajzic, Z, Liu, P, Kalajzic, I, Du, Z, Braut, A, Mina, M, Canalis, E, Rowe, D.W

“…The osteocalcin (OC) and a 2.3 kb fragment of the collagen promoter (Col2.3) have been used to restrict transgenic expression of a variety of proteins to bone…”
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Cortisol inhibits the differentiation and apoptosis of osteoblasts in culture by Pereira, R.M.R, Delany, A.M, Canalis, E

“…Glucocorticoids decrease the replication of cells of the osteoblastic lineage and the function of the osteoblast. However, under certain conditions, they…”
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Insulin-like growth factors and osteoporosis by Canalis, E.

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Effects of cortisol and bone morphogenetic protein-2 on stromal cell differentiation: correlation with CCAAT-enhancer binding protein expression by Pereira, R.C., Delany, A.M., Canalis, E.

“…Bone marrow stroma contain pluripotential cells with the potential to differentiate into various mesenchymal cell lineages. We compared the effect of cortisol…”
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Transgenic Mice Overexpressing Insulin-Like Growth Factor Binding Protein-5 Display Transiently Decreased Osteoblastic Function and Osteopenia by Devlin, R. D, Du, Z, Buccilli, V, Jorgetti, V, Canalis, E

“…Skeletal cells synthesize IGFs and their six IGF binding proteins (IGFBP). IGFBP-5 was reported to stimulate bone cell growth in vitro and selected parameters…”
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The divalent strontium salt S12911 enhances bone cell replication and bone formation in vitro by Canalis, E., Hott, M., Deloffre, P., Tsouderos, Y., Marie, P.J.

“…In this study, we have determined the effect of the divalent strontium salt S12911 on bone cell replication and bone formation in two culture systems. In the…”
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