Search Results - "Canale, Fernando P"

Interleukin-17 signaling influences CD8+ T cell immunity and tumor progression according to the IL-17 receptor subunit expression pattern in cancer cells by Rodriguez, Constanza, Araujo Furlan, Cintia L., Tosello Boari, Jimena, Bossio, Sabrina N., Boccardo, Santiago, Fozzatti, Laura, Canale, Fernando P., Beccaria, Cristian G., Nuñez, Nicolás G., Ceschin, Danilo G., Piaggio, Eliane, Gruppi, Adriana, Montes, Carolina L., Acosta Rodríguez, Eva V.

“…IL-17 immune responses in cancer are controversial, with both tumor-promoting and tumor-repressing effects observed. To clarify the role of IL-17 signaling in…”
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Polyfunctional KLRG-1 + CD57 + Senescent CD4 + T Cells Infiltrate Tumors and Are Expanded in Peripheral Blood From Breast Cancer Patients by Ramello, Maria C, Núñez, Nicolás G, Tosello Boari, Jimena, Bossio, Sabrina N, Canale, Fernando P, Abrate, Carolina, Ponce, Nicolas, Del Castillo, Andrés, Ledesma, Marta, Viel, Sophie, Richer, Wilfrid, Sedlik, Christine, Tiraboschi, Carolina, Muñoz, Marcos, Compagno, Daniel, Gruppi, Adriana, Acosta Rodríguez, Eva V, Piaggio, Eliane, Montes, Carolina L

“…Senescent T cells have been described during aging, chronic infections, and cancer; however, a comprehensive study of the phenotype, function, and…”
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CD39+ conventional CD4+ T cells with exhaustion traits and cytotoxic potential infiltrate tumors and expand upon CTLA-4 blockade by Bossio, Sabrina N., Abrate, Carolina, Tosello Boari, Jimena, Rodriguez, Constanza, Canale, Fernando P., Ramello, María C., Brunotto, Valentina, Richer, Wilfrid, Rocha, Dario, Sedlik, Christine, Vincent-Salomon, Anne, Borcoman, Edith, Del Castillo, Andres, Gruppi, Adriana, Fernandez, Elmer, Acosta Rodríguez, Eva V., Piaggio, Eliane, Montes, Carolina L.

“…Conventional CD4 + T (Tconv) lymphocytes play important roles in tumor immunity; however, their contribution to tumor elimination remains poorly understood…”
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Limited Foxp3 + Regulatory T Cells Response During Acute Trypanosoma cruzi Infection Is Required to Allow the Emergence of Robust Parasite-Specific CD8 + T Cell Immunity by Araujo Furlan, Cintia L, Tosello Boari, Jimena, Rodriguez, Constanza, Canale, Fernando P, Fiocca Vernengo, Facundo, Boccardo, Santiago, Beccaria, Cristian G, Adoue, Véronique, Joffre, Olivier, Gruppi, Adriana, Montes, Carolina L, Acosta Rodriguez, Eva V

“…While it is now acknowledged that CD4 T cells expressing CD25 and Foxp3 (Treg cells) regulate immune responses and, consequently, influence the pathogenesis of…”
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Metabolic modulation of tumours with engineered bacteria for immunotherapy by Canale, Fernando P., Basso, Camilla, Antonini, Gaia, Perotti, Michela, Li, Ning, Sokolovska, Anna, Neumann, Julia, James, Michael J., Geiger, Stefania, Jin, Wenjie, Theurillat, Jean-Philippe, West, Kip A., Leventhal, Daniel S., Lora, Jose M., Sallusto, Federica, Geiger, Roger

“…The availability of l -arginine in tumours is a key determinant of an efficient anti-tumour T cell response 1 – 4 . Consequently, increases of typically low l…”
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CD39 Expression Defines Cell Exhaustion in Tumor-Infiltrating CD8 + T Cells by Canale, Fernando P, Ramello, María C, Núñez, Nicolás, Araujo Furlan, Cintia L, Bossio, Sabrina N, Gorosito Serrán, Melisa, Tosello Boari, Jimena, Del Castillo, Andrés, Ledesma, Marta, Sedlik, Christine, Piaggio, Eliane, Gruppi, Adriana, Acosta Rodríguez, Eva A, Montes, Carolina L

“…The ability of CD8 T lymphocytes to eliminate tumors is limited by their ability to engender an immunosuppressive microenvironment. Here we describe a subset…”
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CD39 Expression Defines Cell Exhaustion in Tumor-Infiltrating CD8 + T Cells-Response by Canale, Fernando P, Ramello, María C, Núñez, Nicolás, Bossio, Sabrina N, Piaggio, Eliane, Gruppi, Adriana, Rodríguez, Eva V Acosta, Montes, Carolina L

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Tumor-associated macrophages restrict CD8 + T cell function through collagen deposition and metabolic reprogramming of the breast cancer microenvironment by Tharp, Kevin M, Kersten, Kelly, Maller, Ori, Timblin, Greg A, Stashko, Connor, Canale, Fernando P, Menjivar, Rosa E, Hayward, Mary-Kate, Berestjuk, Ilona, Ten Hoeve, Johanna, Samad, Bushra, Ironside, Alastrair J, di Magliano, Marina Pasca, Muir, Alexander, Geiger, Roger, Combes, Alexis J, Weaver, Valerie M

“…Tumor progression is accompanied by fibrosis, a condition of excessive extracellular matrix accumulation, which is associated with diminished antitumor immune…”
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Proteomics of immune cells from liver tumors reveals immunotherapy targets by Canale, Fernando P., Neumann, Julia, von Renesse, Janusz, Loggi, Elisabetta, Pecoraro, Matteo, Vogel, Ian, Zoppi, Giada, Antonini, Gaia, Wolf, Tobias, Jin, Wenjie, Zheng, Xiaoqin, La Barba, Giuliano, Birgin, Emrullah, Forkel, Marianne, Nilsson, Tobias, Marone, Romina, Mueller, Henrik, Pelletier, Nadege, Jeker, Lukas T., Civenni, Gianluca, Schlapbach, Christoph, Catapano, Carlo V., Seifert, Lena, Seifert, Adrian M., Gillessen, Silke, De Dosso, Sara, Cristaudi, Alessandra, Rahbari, Nuh N., Ercolani, Giorgio, Geiger, Roger

“…Elucidating the mechanisms by which immune cells become dysfunctional in tumors is critical to developing next-generation immunotherapies. We profiled…”
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