Search Results - "Canal, Clinton E"

Activity of Mitragyna speciosa (“Kratom”) Alkaloids at Serotonin Receptors by León, Francisco, Obeng, Samuel, Mottinelli, Marco, Chen, Yiming, King, Tamara I, Berthold, Erin C, Kamble, Shyam H, Restrepo, Luis F, Patel, Avi, Gamez-Jimenez, Lea R, Lopera-Londoño, Carolina, Hiranita, Takato, Sharma, Abhisheak, Hampson, Aidan J, Canal, Clinton E, McMahon, Lance R, McCurdy, Christopher R

“…Kratom alkaloids have mostly been evaluated for their opioid activity but less at other targets that could contribute to their physiological effects. Here, we…”
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Amnesia produced by altered release of neurotransmitters after intraamygdala injections of a protein synthesis inhibitor by Canal, Clinton E, Chang, Qing, Gold, Paul E

“…Amnesia produced by protein synthesis inhibitors such as anisomycin provides major support for the prevalent view that the formation of long-lasting memories…”
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The serotonin 2C receptor potently modulates the head-twitch response in mice induced by a phenethylamine hallucinogen by Canal, Clinton E., Olaghere da Silva, Uade B., Gresch, Paul J., Watt, Erin E., Sanders-Bush, Elaine, Airey, David C.

“…Rationale Hallucinogenic serotonin 2A (5-HT 2A ) receptor partial agonists, such as (±)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane hydrochloride (DOI),…”
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“Selective” serotonin 5-HT2A receptor antagonists by Casey, Austen B., Cui, Meng, Booth, Raymond G., Canal, Clinton E.

“…[Display omitted] Blockade of the serotonin 5-HT2A G protein-coupled receptor (5-HT2AR) is a fundamental pharmacological characteristic of numerous…”
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Altered brain serotonin 5-HT1A receptor expression and function in juvenile Fmr1 knockout mice by Saraf, Tanishka S., Chen, Yiming, Tyagi, Richa, Canal, Clinton E.

“…There are no approved pharmacotherapies for fragile X syndrome (FXS), a rare neurodevelopmental disorder caused by a mutation in the FMR1 promoter region that…”
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Classics in Chemical Neuroscience: Aripiprazole by Casey, Austen B, Canal, Clinton E

“…Aripiprazole was the first antipsychotic developed to possess agonist properties at dopamine D2 autoreceptors, a groundbreaking strategy that presented a new…”
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Targeting 5-HT 1A Receptors to Correct Perineuronal Net and Social Behavioral Deficits in Fmr1 Knockout Mice, a Model of Fragile X Syndrome by Armstrong, Jessica L, Canal, Clinton E

“…Fragile X syndrome (FXS), caused by FMR1gene silencing and subsequent loss of the RNA-binding protein FMRP, is the leading monogenic cause of intellectual…”
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The serotonin 5-HT2C receptor and the non-addictive nature of classic hallucinogens by Canal, Clinton E, Murnane, Kevin S

“…Classic hallucinogens share pharmacology as serotonin 5-HT2A, 5-HT2B, and 5-HT2C receptor agonists. Unique among most other Schedule 1 drugs, they are…”
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Structure-Activity Relationship Study of Psychostimulant Synthetic Cathinones Reveals Nanomolar Antagonist Potency of α-Pyrrolidinohexiophenone at Human Muscarinic M 2 Receptors by Chen, Yiming, Canal, Clinton E

“…Synthetic cathinones (SCs) are designer, psychostimulant drugs of abuse that primarily act on monoamine transporters; little is known about their off-target…”
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The Need To Improve Reporting of the Pharmacological Action of New Molecules by Canal, Clinton E, Leopoldo, Marcello

“…The molecular characterization of bioactive molecules, for example, small molecules targeting G-protein-coupled receptors, is evolving in complexity, impacting…”
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Structure–Activity Relationship Study of Psychostimulant Synthetic Cathinones Reveals Nanomolar Antagonist Potency of α‑Pyrrolidinohexiophenone at Human Muscarinic M2 Receptors by Chen, Yiming, Canal, Clinton E

“…Synthetic cathinones (SCs) are designer, psychostimulant drugs of abuse that primarily act on monoamine transporters; little is known about their off-target…”
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Spontaneous seizures in adult Fmr1 knockout mice: FVB.129P2-Pde6b+Tyrc-chFmr1tm1Cgr/J by Armstrong, Jessica L., Saraf, Tanishka S., Bhatavdekar, Omkar, Canal, Clinton E.

“…The prevalence of seizures in individuals with fragile X syndrome (FXS) is ~25%; however, there are no reports of spontaneous seizures in the Fmr1 knockout…”
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Targeting 5‐HT1A Receptors to Correct Neuronal Hyperexcitability in Fmr1 Knockout Mice by Saraf, Tanishka S., Yang, Bo, McGlynn, Ryan P., Booth, Raymond G., Canal, Clinton E.

“…Fragile X syndrome (FXS)—caused by FMR1 gene silencing—is a severe neurodevelopmental disorder characterized by intellectual disabilities that are often…”
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Spontaneous seizures in adult Fmr1 knockout mice: FVB.129P2-Pde6b+ Tyr Fmr1/J by Armstrong, Jessica L., Saraf, Tanishka S., Bhatavdekar, Omkar, Canal, Clinton E.

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Ligand-directed serotonin 5-HT2C receptor desensitization and sensitization by Felsing, Daniel E., Canal, Clinton E., Booth, Raymond G.

“…Exposure of G protein–coupled receptors (GPCRs) to agonists can desensitize receptor signaling and lead to drug tolerance, whereas inverse agonists can…”
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Effects of the second-generation "bath salt" cathinone alpha-pyrrolidinopropiophenone (α-PPP) on behavior and monoamine neurochemistry in male mice by Ray, Azizi, Chitre, Neha Milind, Daphney, Cedrick Maceo, Blough, Bruce E., Canal, Clinton E., Murnane, Kevin Sean

“…Rationale Synthetic cathinones (“bath salts”) are β-ketone analogs of amphetamines, yet few studies have examined their potential neurotoxic effects. Objective…”
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Impact of RNA editing on functions of the serotonin 2C receptor in vivo by Olaghere da Silva, Uade B, Morabito, Michael V, Canal, Clinton E, Airey, David C, Emeson, Ronald B, Sanders-Bush, Elaine

“…Transcripts encoding 5-HT(2C) receptors are modified posttranscriptionally by RNA editing, generating up to 24 protein isoforms. In recombinant cells, the…”
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Synthesis and Structure-Activity Relationships of 2,5-Dimethoxy-4-Substituted Phenethylamines and the Discovery of CYB210010: A Potent, Orally Bioavailable and Long-Acting Serotonin 5-HT 2 Receptor Agonist by Varty, Geoffrey B, Canal, Clinton E, Mueller, Tina A, Hartsel, Joshua A, Tyagi, Richa, Avery, Ken, Morgan, Michael E, Reichelt, Amy C, Pathare, Pradip, Stang, Erik, Palfreyman, Michael G, Nivorozhkin, Alex

“…Structure-activity studies of 4-substituted-2,5-dimethoxyphenethylamines led to the discovery of 2,5-dimethoxy-4-thiotrifluoromethylphenethylamines, including…”
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Synthesis and Structure–Activity Relationships of 2,5-Dimethoxy-4-Substituted Phenethylamines and the Discovery of CYB210010: A Potent, Orally Bioavailable and Long-Acting Serotonin 5‑HT2 Receptor Agonist by Varty, Geoffrey B., Canal, Clinton E., Mueller, Tina A., Hartsel, Joshua A., Tyagi, Richa, Avery, Ken, Morgan, Michael E., Reichelt, Amy C., Pathare, Pradip, Stang, Erik, Palfreyman, Michael G., Nivorozhkin, Alex

“…Structure–activity studies of 4-substituted-2,5-dimethoxy­phenethylamines led to the discovery of 2,5-dimethoxy-4-thiotrifluoromethyl­phenethylamines,…”
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The Psychedelic N,N‑Dipropyltryptamine Prevents Seizures in a Mouse Model of Fragile X Syndrome via a Mechanism that Appears Independent of Serotonin and Sigma1 Receptors by Tyagi, Richa, Saraf, Tanishka S., Canal, Clinton E.

“…The serotonergic psychedelic psilocybin shows efficacy in treating neuropsychiatric disorders, though the mechanism(s) underlying its therapeutic effects…”
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