Search Results - "Canada, Justin"
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Exercise Intolerance in Patients With Heart Failure: JACC State-of-the-Art Review
Published in Journal of the American College of Cardiology (07-05-2019)“…Exercise intolerance is the cardinal symptom of heart failure (HF) and is of crucial relevance, because it is associated with a poor quality of life and…”
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Obesity paradox in cardiovascular disease: where do we stand?
Published in Vascular health and risk management (01-05-2019)“…Obesity is associated with an increased risk of developing cardiovascular disease (CVD), particularly heart failure (HF) and coronary heart disease (CHD). The…”
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IL-1 Blockade Reduces Inflammation in Pulmonary Arterial Hypertension and Right Ventricular Failure: A Single-Arm, Open-Label, Phase IB/II Pilot Study
Published in American journal of respiratory and critical care medicine (01-02-2019)“…Inclusion criteria included group 1 PAH (7) (not associated with connective tissue disease, human immunodeficiency virus, portal hypertension, or…”
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Effects of Interleukin-1 Blockade With Anakinra on Aerobic Exercise Capacity in Patients With Heart Failure and Preserved Ejection Fraction (from the D-HART Pilot Study)
Published in The American journal of cardiology (15-01-2014)“…Heart failure with preserved ejection fraction (HFpEF) is a clinical syndrome of exercise intolerance due to impaired myocardial relaxation and/or increased…”
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Interleukin-1 Blockade Inhibits the Acute Inflammatory Response in Patients With ST-Segment-Elevation Myocardial Infarction
Published in Journal of the American Heart Association (03-03-2020)“…Background ST-segment-elevation myocardial infarction is associated with an intense acute inflammatory response and risk of heart failure. We tested whether…”
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Physical activity, sedentary behaviors and all-cause mortality in patients with heart failure: Findings from the NHANES 2007–2014
Published in PloS one (15-07-2022)“…Background Limited data are available examining the effects of both moderate- and vigorous-intensity physical activity (MVPA) and sedentary behavior (SB) on…”
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IL-1 Blockade in Patients With Heart Failure With Preserved Ejection Fraction: Results From DHART2
Published in Circulation. Heart failure (01-08-2018)Get full text
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Effects of Replacing Sedentary Time With Physical Activity on Mortality Among Patients With Heart Failure: National Health and Nutrition Examination Survey Follow-Up Study
Published in Mayo Clinic proceedings (01-10-2022)“…A sedentary lifestyle is prevalent among patients with heart failure (HF) and is associated with poor prognosis and survival, possibly owing to the…”
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Exercise training in cardiac rehabilitation: Setting the right intensity for optimal benefit
Published in Progress in cardiovascular diseases (01-01-2022)“…Cardiac rehabilitation (CR) programs are recommended standard-of-care by all major cardiovascular medicine professional organizations. Exercise training is the…”
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IL-1 Blockade in Patients With Heart Failure With Preserved Ejection Fraction
Published in Circulation. Heart failure (01-08-2018)“…Background Enhanced inflammation may lead to exercise intolerance in heart failure with preserved ejection fraction. The aim of the current study was to…”
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Relation of Hepatic Fibrosis in Nonalcoholic Fatty Liver Disease to Left Ventricular Diastolic Function and Exercise Tolerance
Published in The American journal of cardiology (01-02-2019)“…The purpose of this study was to determine the relation between liver histology, exercise tolerance, and diastolic function in patients with nonalcoholic fatty…”
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Metabolic modulation predicts heart failure tests performance
Published in PloS one (20-06-2019)“…The metabolic changes that accompany changes in Cardiopulmonary testing (CPET) and heart failure biomarkers (HFbio) are not well known. We undertook…”
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Cardiopulmonary exercise testing during the COVID-19 pandemic
Published in Progress in cardiovascular diseases (01-07-2021)“…The outbreak of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has presented a global public health emergency. Although…”
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Phase 1B, Randomized, Double-Blinded, Dose Escalation, Single-Center, Repeat Dose Safety and Pharmacodynamics Study of the Oral NLRP3 Inhibitor Dapansutrile in Subjects With NYHA II–III Systolic Heart Failure
Published in Journal of cardiovascular pharmacology (24-10-2020)“…The NLRP3 inflammasome has been implicated in the development and progression of heart failure. The aim of this study was to determine the safety of an oral…”
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Obesity Contributes to Exercise Intolerance in Heart Failure With Preserved Ejection Fraction
Published in Journal of the American College of Cardiology (06-12-2016)“…Fat-free mass (FFM) index did not correlate with peak Vo2 (R = -0.18; p = 0.39). [...]both BMI (R= -0.58; p = 0.003) and FMI (R = -0.39; p = 0.059) were…”
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Usefulness of Canakinumab to Improve Exercise Capacity in Patients With Long-Term Systolic Heart Failure and Elevated C-Reactive Protein
Published in The American journal of cardiology (15-10-2018)“…Interleukin-1β (IL-1β) is a cytokine involved in atherothrombosis and is known to depress cardiac function. We hypothesized that blocking IL-1β in patients…”
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Effect of interleukin-1 blockade with anakinra on leukocyte count in patients with ST-segment elevation acute myocardial infarction
Published in Scientific reports (24-01-2022)“…Leukocytosis is a common finding in patients with ST elevation myocardial infarction (STEMI) and portends a poor prognosis. Interleukin 1-β regulates…”
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Exercise Cardiovascular Magnetic Resonance: A Review
Published in Journal of magnetic resonance imaging (01-03-2022)“…While pharmacologic stress cardiovascular magnetic resonance imaging (MRI) is a robust noninvasive tool in the diagnosis and prognostication of epicardial…”
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Interleukin-1 Inhibition for the Prevention and Treatment of Heart Failure
Published in Journal of cardiovascular pharmacology (01-06-2024)“…Heart failure (HF) is a complex syndrome that remains a leading cause of morbidity and mortality worldwide. Abundant evidence suggests inflammation plays a key…”
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