Evaluation of perinatal and intrafamilial hepatitis B prevention programmes in a well child clinic: 9-year follow-up study in Turkey

Evaluation of perinatal and intrafamilial hepatitis B prevention programmes in a well child clinic: 9-year follow-up study in Turkey

Evaluating the performance of well child clinics on adherence to recommended perinatal hepatitis B prevention programmes as well as assessing the outcome of infants living with hepatitis B surface antigen (HBsAg)-positive parents is important. A retrospective study was performed of 336 babies who ha...

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Bibliographic Details
Published in:Transactions of the Royal Society of Tropical Medicine and Hygiene Vol. 105; no. 4; pp. 220 - 225
Main Authors: Polat, S., Camurdan, A.D., Aksakal, N., Agladioglu, S., Beyazova, U., Sahin, F., Atak, A., Er, A.
Format: Journal Article
Language:English
Published: Oxford Elsevier Ltd 01-04-2011
Royal Society of Tropical Medicine and Hygiene
Oxford University Press
Subjects:
Antigen positivity
Biological and medical sciences
Carrier State
Female
Follow-Up Studies
General aspects
Guideline Adherence - standards
Hepatitis B
Hepatitis B - immunology
Hepatitis B - prevention & control
Hepatitis B - transmission
Hepatitis B Surface Antigens - analysis
Hepatitis B Vaccines
Human viral diseases
Humans
Infant
Infants
Infectious Disease Transmission, Vertical - prevention & control
Infectious diseases
Male
Medical sciences
Parents
Practice Guidelines as Topic
Retrospective Studies
Serotesting
Turkey
Turkey - epidemiology
Vaccination
Viral diseases
Viral hepatitis
Asia
Turkey
Kenya, Coast, Kwale District, Gazi
Turkey, Ankara
Antigen positivity
Infants
Serotesting
Turkey
Vaccination
Hepatitis B
Human
Family study
Perinatal
Hepatic disease
Infant
Serology
Infection
Antigen
Viral hepatitis B
Prevention
Immunoprophylaxis
Follow up study
Viral disease
Digestive diseases
Tropical medicine
Child
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Summary:Evaluating the performance of well child clinics on adherence to recommended perinatal hepatitis B prevention programmes as well as assessing the outcome of infants living with hepatitis B surface antigen (HBsAg)-positive parents is important. A retrospective study was performed of 336 babies who had at least one HBsAg-positive parent and were followed-up in the well child clinic of Gazi University Hospital (Ankara, Turkey) between 2001 and 2009. Rates of passive immunisation in 109 babies with HBsAg-positive mothers and initiation of hepatitis B vaccination of all 336 babies with HBsAg-positive parents were 98.8% and 100% respectively. Ninety-two babies (27.4%) were lost to follow-up before completing primary immunisation. The recommended perinatal hepatitis B prevention programme was performed successfully in 194 of the 306 infants who were old enough for post-vaccination serotesting (63.4%). One baby became HBsAg-positive, and 88.1% of babies were seroprotected. Hepatitis B surface antibody (anti-HBs) levels were found to be increased if the HBsAg-positive parent was the father. There was a negative correlation between serotesting time and anti-HBs titres. The study infants had a total of 187 siblings and 123 (65.8%) were serotested after completing primary immunisation with 108 found to be seropositive. Although the vaccination rate in the perinatal hepatitis B prevention programme is satisfactory, post-vaccination serotesting and evaluation of infants and their siblings are still deficient.
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ISSN:0035-9203
1878-3503
DOI:10.1016/j.trstmh.2010.12.001