Search Results - "Camprubi‐Rimblas, Marta"
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A long-lasting porcine model of ARDS caused by pneumonia and ventilator-induced lung injury
Published in Critical care (London, England) (16-06-2023)“…Animal models of acute respiratory distress syndrome (ARDS) do not completely resemble human ARDS, struggling translational research. We aimed to characterize…”
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Comparison of direct and indirect models of early induced acute lung injury
Published in Intensive care medicine experimental (18-12-2020)“…Background The animal experimental counterpart of human acute respiratory distress syndrome (ARDS) is acute lung injury (ALI). Most models of ALI involve…”
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Efficient Nebulization and Pulmonary Biodistribution of Polymeric Nanocarriers in an Acute Lung Injury Preclinical Model
Published in Small science (01-09-2024)“…Acute respiratory distress syndrome (ARDS) is a clinical syndrome characterized by acute hypoxemic respiratory failure. Pneumonia and sepsis are the most…”
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4
Nebulised heparin as a treatment for COVID-19: scientific rationale and a call for randomised evidence
Published in Critical care (London, England) (22-07-2020)“…Nebulised unfractionated heparin (UFH) has a strong scientific and biological rationale and warrants urgent investigation of its therapeutic potential, for…”
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Effects of nebulized antithrombin and heparin on inflammatory and coagulation alterations in an acute lung injury model in rats
Published in Journal of thrombosis and haemostasis (01-03-2020)“…Background During acute respiratory distress syndrome, proinflammatory mediators inhibit natural anticoagulant factors, which alter the normal balance between…”
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INHALEd nebulised unfractionated HEParin for the treatment of hospitalised patients with COVID‐19 (INHALE‐HEP): Protocol and statistical analysis plan for an investigator‐initiated international metatrial of randomised studies
Published in British journal of clinical pharmacology (01-08-2021)“…Aims Inhaled nebulised unfractionated heparin (UFH) has a strong scientific and biological rationale that warrants urgent investigation of its therapeutic…”
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Lung Extracellular Matrix Hydrogels Enhance Preservation of Type II Phenotype in Primary Alveolar Epithelial Cells
Published in International journal of molecular sciences (28-04-2022)“…One of the main limitations of in vitro studies on lung diseases is the difficulty of maintaining the type II phenotype of alveolar epithelial cells in…”
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Role of heparin in pulmonary cell populations in an in-vitro model of acute lung injury
Published in Respiratory research (10-05-2017)“…In the early stages of acute respiratory distress syndrome (ARDS), pro-inflammatory mediators inhibit natural anticoagulant factors and initiate an increase in…”
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Methotrexate Ameliorates Systemic Inflammation and Septic Associated-Lung Damage in a Cecal Ligation and Puncture Septic Rat Model
Published in International journal of molecular sciences (04-09-2021)“…Sepsis is a serious, heterogeneous clinical entity produced by a severe and systemic host inflammatory response to infection. Methotrexate (MTX) is a…”
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Inhaled amikacin for pneumonia treatment and dissemination prevention: an experimental model of severe monolateral Pseudomonas aeruginosa pneumonia
Published in Critical care (London, England) (14-02-2023)“…Pseudomonas aeruginosa pneumonia is commonly treated with systemic antibiotics to ensure adequate treatment of multidrug resistant (MDR) bacteria. However,…”
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Intratracheal instillation of alveolar type II cells enhances recovery from acute lung injury in rats
Published in The Journal of heart and lung transplantation (01-06-2018)“…Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are characterized by excess production of inflammatory factors. Alveolar type II (ATII)…”
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Priming Mesenchymal Stem Cells with Lipopolysaccharide Boosts the Immunomodulatory and Regenerative Activity of Secreted Extracellular Vesicles
Published in Pharmaceutics (10-10-2024)“…Mesenchymal stem cells (MSCs)-derived extracellular vesicles (EVs) have been proposed as an alternative to live-cell administration for Acute Respiratory…”
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The role of hypercapnia in acute respiratory failure
Published in Intensive care medicine experimental (25-07-2019)“…The biological effects and physiological consequences of hypercapnia are increasingly understood. The literature on hypercapnia is confusing, and at times…”
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Fluorescent PLGA Nanocarriers for Pulmonary Administration: Influence of the Surface Charge
Published in Pharmaceutics (11-07-2022)“…Nearly four million yearly deaths can be attributed to respiratory diseases, prompting a huge worldwide health emergency. Additionally, the COVID-19 pandemic’s…”
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Alveolar Type II Cells or Mesenchymal Stem Cells: Comparison of Two Different Cell Therapies for the Treatment of Acute Lung Injury in Rats
Published in Cells (Basel, Switzerland) (31-07-2020)“…The use of cell therapies has recently increased for the treatment of pulmonary diseases. Mesenchymal stem/stromal cells (MSCs) and alveolar type II cells…”
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Bioengineered extracellular vesicles: future of precision medicine for sepsis
Published in Intensive care medicine experimental (10-03-2023)“…Sepsis is a syndromic response to infection and is frequently a final common pathway to death from many infectious diseases worldwide. The complexity and high…”
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Evaluation of the Kinetics of Pancreatic Stone Protein as a Predictor of Ventilator-Associated Pneumonia
Published in Biomedicines (29-09-2023)“…BACKGROUND: Ventilator-associated pneumonia (VAP) is a severe condition. Early and adequate antibiotic treatment is the most important strategy for improving…”
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Nebulized Heparin Attenuates Pulmonary Coagulopathy and Inflammation through Alveolar Macrophages in a Rat Model of Acute Lung Injury
Published in Thrombosis and haemostasis (01-11-2017)“…Alveolar macrophages play a key role in the development and resolution of acute respiratory distress syndrome (ARDS), modulating the inflammatory response and…”
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Anticoagulant therapy in acute respiratory distress syndrome
Published in Annals of translational medicine (01-01-2018)“…Acute respiratory distress syndrome (ARDS) presents a complex pathophysiology characterized by pulmonary activated coagulation and reduced fibrinolysis…”
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Cell therapy for the treatment of sepsis and acute respiratory distress syndrome
Published in Annals of translational medicine (01-11-2017)“…Sepsis and acute respiratory distress syndrome (ARDS) are life threating diseases with high mortality and morbidity in all the critical care units around the…”
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