The surgical viability and radiological monitoring of brain implants of bioactive micro-seeds in an animal model
The interstitial implant is a therapeutic modality in brachytherapy of the head and neck. Presently, the seeds implanted in tumors in the central nervous system are metallic I-125. After the full emission of the radionuclide, the seed remains inert in the implanted area. Bioactive ceramic seeds have...
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| Published in: | Brazilian archives of biology and technology Vol. 48; no. spe2; pp. 109 - 113 |
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| Main Authors: | , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Tecpar
01-10-2005
Instituto de Tecnologia do Paraná (Tecpar) |
| Subjects: | |
| Online Access: | Get full text |
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| Summary: | The interstitial implant is a therapeutic modality in brachytherapy of the head and neck. Presently, the seeds implanted in tumors in the central nervous system are metallic I-125. After the full emission of the radionuclide, the seed remains inert in the implanted area. Bioactive ceramic seeds have been prepared for this research group incorporating Sm-152 to be active in Sm-153. The main goal of the present study is the development of a the surgical technique for implanting the biodegradable radioactive micro-seeds in the brains of rabbits, as well as the observation of the clinical reactions of the animal after implantation of two sets of three seeds. The surgical procedure consisted of performing two separate perforations 10 mm from each other in the skull, permitting the implantation of two groups of three seeds, totaling six seeds. The results of the pilot study showed the effectiveness of the surgical procedure and of the biocompatibility of the seeds and the lack of presence of adverse reactions, functional sequels, or inflammation in a follow up 50 days post-surgery. Such seeds of reduced volume, 0.2 x 1.6 mm, could be monitored by computerized tomography 30 days after implanting.
Os implantes intersticiais podem ser utilizados em braquiterapia de cabeça e pescoço. Atualmente as sementes implantadas no CNS são de I-125 metálicas. Após o decaimento do radioisótopo, a semente fica inerte na região implantada. Sementes cerâmicas bioativas tem sido preparadas pelo grupo de pesquisa incorporando Sm-152. O presente estudo tem o objetivo de viabilizar a técnica cirúrgica de implantes de microsementes biodegradáveis não radioativas no cérebro de coelhos, bem como verificar as reações clínicas e funcionais do animal ao corpo estranho implantado. O procedimento cirúrgico compreendeu em proceder duas perfurações separadas em 10mm na calota craniana onde foi possível a implantação de dois conjuntos de três sementes, totalizando seis sementes. Os resultados do estudo piloto evidenciam a eficácia do procedimento cirúrgico e do material implantado, já que não foram encontradas reações adversas, seqüelas funcionais, ou resposta inflamatória durante 30 dias pós-cirurgia. Tais sementes de reduzido volume, 0.2x1.6mm, puderam ser monitoradas por tomografia computadorizada. |
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| Bibliography: | 10.1590/S1516-89132005000700016 http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132005000700016 |
| ISSN: | 1516-8913 1516-8913 1678-4324 |
| DOI: | 10.1590/S1516-89132005000700016 |