Oxidative Stress Increased in Pregnant Women with Iodine Deficiency

Oxidative Stress Increased in Pregnant Women with Iodine Deficiency

Iodine is an essential element trace for the synthesis of maternal thyroid hormones needed to support normal fetal development; it also acts as an antioxidant directly or induce antioxidant enzymes indirectly. Iodine deficiency and oxidative stress are associated with pregnancy complications. This s...

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Bibliographic Details
Published in:Biological trace element research Vol. 157; no. 3; pp. 211 - 217
Main Authors: Vidal, Zendy Evelyn Olivo, Rufino, Sergio Cuellar, Tlaxcalteco, Esteban Hernández, Trejo, Cirenia Hernández, Campos, Raúl Martínez, Meza, Mónica Navarro, Rodríguez, Rocío Coutiño, Arroyo-Helguera, Omar
Format: Journal Article
Language:English
Published: Boston Springer-Verlag 01-03-2014
Springer US
Springer Nature B.V
Subjects:
Adolescent
Adult
Antioxidants
Antioxidants - metabolism
Biochemistry
Biomedical and Life Sciences
Biotechnology
catalase
Cross-Sectional Studies
Female
fetal development
Hormones
Humans
Iodine
Iodine - deficiency
Iodine - metabolism
Iodine - urine
Life Sciences
Middle Aged
Nutrient deficiency
Nutrition
Oncology
Oxidative Stress
Pregnancy
pregnancy complications
Pregnancy Complications - enzymology
Pregnancy Complications - metabolism
pregnant women
Salt
superoxide dismutase
Superoxide Dismutase - metabolism
Thyroid
thyroid hormones
Women
Young Adult
Antioxidant status
Oxidative stress
Gestation
Pregnant women
Iodine
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Summary:Iodine is an essential element trace for the synthesis of maternal thyroid hormones needed to support normal fetal development; it also acts as an antioxidant directly or induce antioxidant enzymes indirectly. Iodine deficiency and oxidative stress are associated with pregnancy complications. This study aimed to assess the urinary iodine concentration and its relationship with the antioxidant and oxidative stress status during gestation. Pregnant women were consecutively recruited from an obstetric clinic during all gestation trimesters, and urinary iodine concentration, antioxidant, and oxidative stress were determined. Results showed that 70 % of pregnant women have optimal iodine levels (150–200 μg/L), while approximately 30 % showed mild iodine deficiency (50–99 μg/L). Oxidative stress was significantly higher, and the antioxidant status was also compromised as evidenced by decreased total antioxidant status and superoxide dismutase (SOD) activity in pregnant women with mild iodine deficiency than pregnant women with optimal iodine levels. Significant positive correlations were noted between optimal iodine levels and total antioxidant status. Oxidative stress was significantly correlated with mild iodine deficiency. However, no significant correlation was found between iodine levels and SOD and catalase activities. In conclusion, for the first time, these data suggest a correlation between iodine levels and the antioxidant status during pregnancy.
Bibliography:http://dx.doi.org/10.1007/s12011-014-9898-6
ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0163-4984
1559-0720
DOI:10.1007/s12011-014-9898-6