Impact of COVID-19 critical illness on functional status, fatigue symptoms, and health-related quality of life one-year after hospital discharge: a systematic review and meta-analysis

To estimate the prevalence and severity of impairments in functional status, fatigue, and health-related quality of life (HRQoL) among critical COVID-19 survivors one-year after hospital discharge. A systematic review was conducted following PRISMA statement and registered in PROSPERO (CRD4202125835...

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Bibliographic Details
Published in:	Disability and rehabilitation Vol. 46; no. 18; pp. 4086 - 4097
Main Authors:	Gesser, Ana Flávia, Campos, Mariana Lanzoni, Artismo, Regiana Santos, Karloh, Manuela, Matte, Darlan Laurício
Format:	Journal Article
Language:	English
Published:	England 01-09-2024
Subjects:	COVID-19 - epidemiology Critical Illness Fatigue - epidemiology Functional Status Humans Patient Discharge Quality of Life SARS-CoV-2 Survivors COVID-19 exercise tolerance fatigue follow-up studies quality of life intensive care units
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Summary:	To estimate the prevalence and severity of impairments in functional status, fatigue, and health-related quality of life (HRQoL) among critical COVID-19 survivors one-year after hospital discharge. A systematic review was conducted following PRISMA statement and registered in PROSPERO (CRD42021258356), with searches in eight databases. Observational studies were selected. The prevalence meta-analysis of abnormalities was performed using random-effects models. Risk of bias was evaluated using the National Heart, Lung, and Blood Institute tool. Twenty studies were included, with data collected between 12 and 13.5 months after hospital discharge and a total of 1828 participants. Of these, 71% were men, and 77.7% were intubated in the intensive care unit (ICU). Impairments and sequelae were identified in varying prevalence and degrees, with greater impact on functional capacity and physical components of fatigue and HRQoL. The prevalence of abnormalities of 32.3% [95% CI 23.9; 41.9] found in the meta-analysis is substantially high. Most studies were classified as having fair and poor quality. Critical COVID-19 survivors experience impairments in functional status, fatigue, and HRQoL to varying degrees one-year after hospital discharge, particularly among patients who stayed in the ICU and on MV for a prolonged period.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Undefined-1 ObjectType-Feature-3 ObjectType-Review-4 content type line 23
ISSN:	0963-8288 1464-5165 1464-5165
DOI:	10.1080/09638288.2023.2266365