Search Results - "Campos, Kevin R"

The importance of synthetic chemistry in the pharmaceutical industry by Campos, Kevin R, Coleman, Paul J, Alvarez, Juan C, Dreher, Spencer D, Garbaccio, Robert M, Terrett, Nicholas K, Tillyer, Richard D, Truppo, Matthew D, Parmee, Emma R

“…Innovations in synthetic chemistry have enabled the discovery of many breakthrough therapies that have improved human health over the past century. In the face…”
Get full text

Design of an in vitro biocatalytic cascade for the manufacture of islatravir by Huffman, Mark A, Fryszkowska, Anna, Alvizo, Oscar, Borra-Garske, Margie, Campos, Kevin R, Canada, Keith A, Devine, Paul N, Duan, Da, Forstater, Jacob H, Grosser, Shane T, Halsey, Holst M, Hughes, Gregory J, Jo, Junyong, Joyce, Leo A, Kolev, Joshua N, Liang, Jack, Maloney, Kevin M, Mann, Benjamin F, Marshall, Nicholas M, McLaughlin, Mark, Moore, Jeffrey C, Murphy, Grant S, Nawrat, Christopher C, Nazor, Jovana, Novick, Scott, Patel, Niki R, Rodriguez-Granillo, Agustina, Robaire, Sandra A, Sherer, Edward C, Truppo, Matthew D, Whittaker, Aaron M, Verma, Deeptak, Xiao, Li, Xu, Yingju, Yang, Hao

“…Enzyme-catalyzed reactions have begun to transform pharmaceutical manufacturing, offering levels of selectivity and tunability that can dramatically improve…”
Get full text

Asymmetric Deprotonation of N-Boc Piperidine: React IR Monitoring and Mechanistic Aspects by Stead, Darren, Carbone, Giorgio, O’Brien, Peter, Campos, Kevin R, Coldham, Iain, Sanderson, Adam

“…The high yielding asymmetric deprotonation trapping of N-Boc piperidine is successfully realized using s-BuLi and a (+)-sparteine surrogate. Monitoring of the…”
Get full text

An Experimental and in Situ IR Spectroscopic Study of the Lithiation–Substitution of N-Boc-2-phenylpyrrolidine and -piperidine: Controlling the Formation of Quaternary Stereocenters by Sheikh, Nadeem S, Leonori, Daniele, Barker, Graeme, Firth, James D, Campos, Kevin R, Meijer, Anthony J. H. M, O’Brien, Peter, Coldham, Iain

“…A general and enantioselective synthesis of 2-substituted 2-phenylpyrrolidines and -piperidines, an important class of pharmaceutically relevant compounds that…”
Get full text

Preparation of Enamides via Palladium-Catalyzed Amidation of Enol Tosylates by Klapars, Artis, Campos, Kevin R, Chen, Cheng-yi, Volante, Ralph P

“…A Pd-catalyzed coupling of enol tosylates and amides has been developed. Ligand screening revealed dipf as the most general ligand for this transformation. A…”
Get full text

Application of Chiral Mixed Phosphorus/Sulfur Ligands to Enantioselective Rhodium-Catalyzed Dehydroamino Acid Hydrogenation and Ketone Hydrosilylation Processes by Evans, David A, Michael, Forrest E, Tedrow, Jason S, Campos, Kevin R

“…Chiral mixed phosphorus/sulfur ligands 1 − 3 have been shown to be effective in enantioselective Rh-catalyzed dehydroamino acid hydrogenation and ketone…”
Get full text

Application of Chiral Mixed Phosphorus/Sulfur Ligands to Palladium-Catalyzed Allylic Substitutions by Evans, David A, Campos, Kevin R, Tedrow, Jason S, Michael, Forrest E, Gagné, Michel R

“…A modular approach to the synthesis of a class of mixed phosphorus/sulfur ligands was designed to identify important ligand structural features for…”
Get full text

A General Synthesis of Substituted Indoles from Cyclic Enol Ethers and Enol Lactones by Campos, Kevin R, Woo, Jacqueline C. S, Lee, Sandra, Tillyer, Richard D

“…A general method was developed for the one-pot synthesis of highly functionalized indoles from simple, commercially available aryl hydrazines and cyclic enol…”
Get full text

Bis(oxazoline) and Bis(oxazolinyl)pyridine Copper Complexes as Enantioselective Diels−Alder Catalysts:  Reaction Scope and Synthetic Applications by Evans, David A, Barnes, David M, Johnson, Jeffrey S, Lectka, Thomas, von Matt, Peter, Miller, Scott J, Murry, Jerry A, Norcross, Roger D, Shaughnessy, Eileen A, Campos, Kevin R

“…The scope of the Diels−Alder reaction catalyzed by bis(oxazoline) copper complexes has been investigated. In particular, [Cu((S,S)-t-Bu-box)](SbF6)2 (1b) has…”
Get full text

Enantioselective Deprotonation as a Vehicle for the Asymmetric Synthesis of C2-Symmetric P-Chiral Diphosphines by Muci, Alexander R, Campos, Kevin R, Evans, David A

Get full text

Enantioselective, Biocatalytic Reduction of 3-Substituted Cyclopentenones: Application to the Asymmetric Synthesis of an hNK-1 Receptor Antagonist by Campos, Kevin R, Klapars, Artis, Kohmura, Yoshinori, Pollard, David, Ishibashi, Hideaki, Kato, Shinji, Takezawa, Akihiro, Waldman, Jacob H, Wallace, Debra J, Chen, Cheng-yi, Yasuda, Nobuyoshi

“…A convergent and enantioselective route to the hNK-1 receptor antagonist (1) is described, which sets all six stereogenic centers with high…”
Get full text

Enantioselective Synthesis of Hemiaminals via Pd-Catalyzed C–N Coupling with Chiral Bisphosphine Mono-oxides by Li, Hongming, Belyk, Kevin M, Yin, Jingjun, Chen, Qinghao, Hyde, Alan, Ji, Yining, Oliver, Steven, Tudge, Matthew T, Campeau, Louis-Charles, Campos, Kevin R

“…A novel approach to hemiaminal synthesis via palladium-catalyzed C–N coupling with chiral bisphosphine mono-oxides is described. This efficient new method…”
Get full text

Go to the Board: A Journey through the Life of Professor David A. Evans by Aye, Yimon, Campos, Kevin R., MacMillan, David W. C.

“…By taking a journey through the events that happened during Professor David A. Evans’ lifetime in the context of chemical synthesis and drug discovery, this…”
Get full text

Enantioselective, Palladium-Catalyzed α-Arylation of N-Boc Pyrrolidine: In Situ React IR Spectroscopic Monitoring, Scope, and Synthetic Applications by Barker, Graeme, McGrath, Julia L, Klapars, Artis, Stead, Darren, Zhou, George, Campos, Kevin R, O’Brien, Peter

“…A comprehensive study of the enantioselective Pd-catalyzed α-arylation of N-Boc pyrrolidine has been carried out. The protocol involves deprotonation of N-Boc…”
Get full text

A kinase-cGAS cascade to synthesize a therapeutic STING activator by McIntosh, John A., Liu, Zhijian, Andresen, Brian M., Marzijarani, Nastaran Salehi, Moore, Jeffrey C., Marshall, Nicholas M., Borra-Garske, Margie, Obligacion, Jennifer V., Fier, Patrick S., Peng, Feng, Forstater, Jacob H., Winston, Matthew S., An, Chihui, Chang, Wonsuk, Lim, Jongwon, Huffman, Mark A., Miller, Steven P., Tsay, Fuh-Rong, Altman, Michael D., Lesburg, Charles A., Steinhuebel, Dietrich, Trotter, B. Wesley, Cumming, Jared N., Northrup, Alan, Bu, Xiaodong, Mann, Benjamin F., Biba, Mirlinda, Hiraga, Kaori, Murphy, Grant S., Kolev, Joshua N., Makarewicz, Amanda, Pan, Weilan, Farasat, Iman, Bade, Rachel S., Stone, Kevin, Duan, Da, Alvizo, Oscar, Adpressa, Donovan, Guetschow, Erik, Hoyt, Erik, Regalado, Erik L., Castro, Steve, Rivera, Nelo, Smith, Joseph P., Wang, Fengqiang, Crespo, Alejandro, Verma, Deeptak, Axnanda, Stephanus, Dance, Zachary E. X., Devine, Paul N., Tschaen, David, Canada, Keith A., Bulger, Paul G., Sherry, Benjamin D., Truppo, Matthew D., Ruck, Rebecca T., Campeau, Louis-Charles, Bennett, David Jonathan, Humphrey, Guy R., Campos, Kevin R., Maddess, Matthew L.

“…The introduction of molecular complexity in an atom- and step-efficient manner remains an outstanding goal in modern synthetic chemistry. Artificial…”
Get full text

Diamine-Free Lithiation−Trapping of N-Boc Heterocycles using s-BuLi in THF by Barker, Graeme, O’Brien, Peter, Campos, Kevin R

“…A diamine-free protocol for the s-BuLi-mediated lithiation−trapping of N-Boc heterocycles has been developed. In the optimized procedure, lithiation is…”
Get full text

An Improved Procedure for the Preparation of 2,2-Bis[2-[4(S)- tert-butyl-1,3-oxazolinyl]]propane [(S,S)-tert-Butylbis(oxazoline)] and Derived Copper(II) Complexes by Evans, David A, Peterson, Gretchen S, Johnson, Jeffrey S, Barnes, David M, Campos, Kevin R, Woerpel, Keith A

Get full text

Synthesis and Absolute Stereochemical Assignment of (+)-Miyakolide by Evans, David A, Ripin, David H. B, Halstead, David P, Campos, Kevin R

“…The first total synthesis of the marine macrolide miyakolide has been achieved, and its absolute stereochemistry has been determined. The carbon skeleton is…”
Get full text

Chiral Mixed Phosphorus/Sulfur Ligands for Palladium-Catalyzed Allylic Alkylations and Aminations by Evans, David A, Campos, Kevin R, Tedrow, Jason S, Michael, Forrest E, Gagné, Michel R

Get full text

Efficient synthesis of antiviral agent uprifosbuvir enabled by new synthetic methods by Klapars, Artis, Chung, John Y. L, Limanto, John, Calabria, Ralph, Campeau, Louis-Charles, Campos, Kevin R, Chen, Wenyong, Dalby, Stephen M, Davis, Tyler A, DiRocco, Daniel A, Hyde, Alan M, Kassim, Amude M, Larsen, Mona Utne, Liu, Guiquan, Maligres, Peter E, Moment, Aaron, Peng, Feng, Ruck, Rebecca T, Shevlin, Michael, Simmons, Bryon L, Song, Zhiguo Jake, Tan, Lushi, Wright, Timothy J, Zultanski, Susan L

“…An efficient route to the HCV antiviral agent uprifosbuvir was developed in 5 steps from readily available uridine in 50% overall yield. This concise synthesis…”
Get full text