Postpartum Genital Melanoma - A Case Report

Postpartum Genital Melanoma - A Case Report

Melanomas of the female genital tract may occur in the vulva, the vagina, the ovary or the cervix. Pregnancy has been considered an aggravating factor in the evolution and prognosis of melanoma. A 35-year-old female presented with vaginal bleeding 2 months after a term cesarean delivery. An endovagi...

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Bibliographic Details
Published in:Revista Brasileira de ginecologia e obstetrícia Vol. 40; no. 3; pp. 163 - 167
Main Authors: Nai, Gisele Alborghetti, Bazan, Andressa, Rocha, Caroline Andrade, Nagy, Juliana Souza, Campos, Isadora Tanaka
Format: Journal Article
Language:English
Published: Brazil Thieme Revinter Publicações Ltda 01-03-2018
Federação Brasileira das Sociedades de Ginecologia e Obstetrícia
Subjects:
Adult
Case Report
estrogens
Female
Humans
melanoma
Melanoma - diagnosis
Melanoma - therapy
OBSTETRICS & GYNECOLOGY
Postpartum Period
pregnancy
prognosis
Uterine Cervical Neoplasms - diagnosis
Uterine Cervical Neoplasms - therapy
vaginal neoplasms
pregnancy
estrogens
melanoma
estrogênios
gestação
prognóstico
neoplasias vaginais
prognosis
vaginal neoplasms
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Summary:Melanomas of the female genital tract may occur in the vulva, the vagina, the ovary or the cervix. Pregnancy has been considered an aggravating factor in the evolution and prognosis of melanoma. A 35-year-old female presented with vaginal bleeding 2 months after a term cesarean delivery. An endovaginal ultrasound revealed a lesion in the uterine cervix. The pathological report revealed a small round-cell neoplasm, and the immunohistochemistry confirmed the diagnosis of malignant melanoma. A positron emission tomography revealed an expansive hypermetabolic lesion centered on the cervix, and hypermetabolic lesions in the liver and right kidney. Non-surgical treatment was provided, with biochemotherapy followed by ipilimumab and nivolumab. The patient died one year later. Postpartum vaginal bleeding, even if late-onset, should be investigated, as it may be a pregnancy-associated malignant melanoma, which has a poor prognosis.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
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ISSN:0100-7203
1806-9339
1806-9339
DOI:10.1055/s-0038-1624578