Gingival granulomatosis with polyangiitis (Wegener's granulomatosis) as a primary manifestation of the disease

Granulomatosis with polyangiitis (GPA) is a potentially lethal disease characterized by systemic necrotizing vasculitis, which affects small‐ and medium‐sized blood vessels and is often associated with serum cytoplasmic antineutrophil cytoplasmic antibody. The upper and lower respiratory tract and k...

Full description

Saved in:

Bibliographic Details
Published in:	Australian dental journal Vol. 62; no. 1; pp. 102 - 106
Main Authors:	Fonseca, FP, Benites, BM, Ferrari, ALV, Sachetto, Z, Campos, GV, Almeida, OP, Fregnani, ER
Format:	Journal Article
Language:	English
Published:	Australia 01-03-2017
Subjects:	Adrenal Cortex Hormones - administration & dosage Adrenal Cortex Hormones - therapeutic use Aged ANCA Antibodies, Antineutrophil Cytoplasmic - blood Diagnosis, Differential Drug Therapy, Combination Fatal Outcome Female Gingival Diseases - blood Gingival Diseases - diagnosis Gingival Diseases - drug therapy granulomatosis with polyangiitis Granulomatosis with Polyangiitis - blood Granulomatosis with Polyangiitis - diagnosis Granulomatosis with Polyangiitis - diagnostic imaging Granulomatosis with Polyangiitis - drug therapy Humans Immunosuppressive Agents - administration & dosage Immunosuppressive Agents - therapeutic use necrotizing vasculitis oral cavity Wegener's granulomatosis granulomatosis with polyangiitis necrotizing vasculitis oral cavity ANCA Wegener's granulomatosis
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Granulomatosis with polyangiitis (GPA) is a potentially lethal disease characterized by systemic necrotizing vasculitis, which affects small‐ and medium‐sized blood vessels and is often associated with serum cytoplasmic antineutrophil cytoplasmic antibody. The upper and lower respiratory tract and kidney are the most involved sites, but oral lesions can be identified in 6–13% of the cases, whereas in only 2% of the cases, oral manifestations represent the first signal of the disease usually as gingival swellings or unspecific ulcerations. Without treatment, the mainstay of which is the combination of immunosuppressants and systemic corticosteroids, GPA may run a fatal course. In this report we describe an original case of GPA affecting a 75‐year‐old female patient referred to our service due to a gingival swelling with 3‐month duration. Although the patient was correctly diagnosed and promptly treated, she died 3 months after the initial diagnosis.
ISSN:	0045-0421 1834-7819
DOI:	10.1111/adj.12441