HE4 can Help Discriminate Women with Malignant Ovarian Tumors only if CA125 Levels are Elevated

Objective To evaluate the performance of mesothelin, CA125, HE4 and ROMA index in the detection of malignant ovarian tumors. Study Design This is a cross-sectional study including 199 women with adnexal masses (67 with malignant tumors and 132 with benign tumors) and 150 healthy women (controls). We...

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Published in:	The International journal of biological markers Vol. 28; no. 4; pp. 377 - 386
Main Authors:	Pitta, Denise da Rocha, Sarian, Luis Otávio, Aparecida Campos, Elisabete, Andrade, Liliana Lucci De Angelo, Sallum, Luis Felipe, Bragança, Joana Froes, Campos, Camila de Mello, Derchain, Sophie
Format:	Journal Article
Language:	English
Published:	London, England SAGE Publications 01-10-2013
Subjects:	Algorithms Biomarkers, Tumor - blood CA-125 Antigen - blood Case-Control Studies Cross-Sectional Studies Diagnosis, Differential Female GPI-Linked Proteins - blood Humans Membrane Proteins - blood Ovarian Neoplasms - blood Ovarian Neoplasms - diagnosis Ovarian Neoplasms - pathology Proteins - metabolism CA125 Mesothelin Ovarian mass HE4 ROMA
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Summary:	Objective To evaluate the performance of mesothelin, CA125, HE4 and ROMA index in the detection of malignant ovarian tumors. Study Design This is a cross-sectional study including 199 women with adnexal masses (67 with malignant tumors and 132 with benign tumors) and 150 healthy women (controls). We used a recursive multivariate partitioning algorithm to assess the contribution of each of the serum markers and the ROMA index to the discrimination of women with malignant tumors. Also, the areas under the ROC curves (AUC) for each of the serum markers and for the ROMA index were compared using the Venkatraman's projection-permutation test. Results In the recursive model, CA125 had the best performance in discriminating women with malignant tumors. In women with normal-range CA125 levels, none of the other markers contributed to the discrimination of women with malignant tumors. In women with elevated CA125 levels, elevated HE4 levels were associated with an increased risk of harboring a malignant tumor. The AUC for mesothelin was smaller than that for all the other curves, and both the ROMA index and CA125 had better AUC than HE4. Conclusion In women with normal CA125 levels, neither mesothelin nor HE4 contributed to discriminate women with malignant ovarian tumors; however, for women with elevated CA125 levels HE4 may help discriminating those who have a malignant ovarian tumor.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0393-6155 1724-6008
DOI:	10.5301/JBM.5000029