Search Results - "Campos, Alejandro"
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E3 Ligase TRAF6 Regulates Akt Ubiquitination and Activation
Published in Science (American Association for the Advancement of Science) (28-08-2009)“…Akt signaling plays a central role in many biological functions, such as cell proliferation and apoptosis. Because Akt (also known as protein kinase B) resides…”
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Development and verification of the coupled thermal–hydraulic code – TRACE/SCF based on the ICoCo interface and the SALOME platform
Published in Annals of nuclear energy (01-06-2021)“…•The coupling code executes through the GUI supported by SALOME.•TRACE and SCF have explicit meshes.•Data mapping within the coupling code is automatic and…”
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ERK5 signalling rescues intestinal epithelial turnover and tumour cell proliferation upon ERK1/2 abrogation
Published in Nature communications (17-05-2016)“…The ERK1/2 MAPK signalling module integrates extracellular cues that induce proliferation and differentiation of epithelial lineages, and is an established…”
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Mary and David Medd's work: domesticity in postwar British school design (1949-72)
Published in Oxford review of education (03-09-2021)“…This article focuses on the schools developed by Mary and David Medd within the Ministry of Education in Great Britain, 1949-1976. Their main contribution to…”
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S2120 Tirzepatide and MASLD: Real-World Outcomes in Patients With Overweight and Obesity
Published in The American journal of gastroenterology (01-10-2024)Get full text
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Personal values as predictors of entrepreneurial intentions of university students
Published in Journal of evolutionary studies in business (01-07-2021)“…Considering entrepreneurship as a set of actions performed by a subject, and behavior one of the main predictors of actions, this work presents a study based…”
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Site-specific Lys-63-linked Tumor Necrosis Factor Receptor-associated Factor 6 Auto-ubiquitination Is a Critical Determinant of IκB Kinase Activation
Published in The Journal of biological chemistry (09-02-2007)“…Tumor necrosis factor (TNF) receptor-associated factor 6 (TRAF6) is a key mediator in proximal signaling of the interleukin-1/Toll-like receptor and the TNF…”
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Integrative Hedonic and Homeostatic Food Intake Regulation by the Central Nervous System: Insights from Neuroimaging
Published in Brain sciences (24-03-2022)“…Food intake regulation in humans is a complex process controlled by the dynamic interaction of homeostatic and hedonic systems. Homeostatic regulation is…”
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Metastasis is a highly stressful process
Published in Cancer and metastasis reviews (01-12-2020)Get full text
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E2 interaction and dimerization in the crystal structure of TRAF6
Published in Nature structural & molecular biology (01-06-2009)“…The signaling adaptor TRAF6 is a ubiquitin E3 ligase whose activity can lead to activation of NF-κB and MAPK pathways. New data based on the structure of TRAF6…”
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Intrusion Detection for IoT Environments Through Side-Channel and Machine Learning Techniques
Published in IEEE access (2024)“…The rise of the Internet of Things (IoT) technology during the past decade has resulted in multiple applications across a large variety of fields. Some of the…”
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Unmet needs in autoimmune hepatitis: Results of the prospective multicentre European Reference Network Registry (R‐LIVER)
Published in Liver international (01-10-2024)“…Background and Aims The European Reference Network on Hepatological Diseases (ERN RARE‐LIVER) launched the prospective, multicentre, quality‐controlled R‐LIVER…”
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The RING Domain and First Zinc Finger of TRAF6 Coordinate Signaling by Interleukin-1, Lipopolysaccharide, and RANKL
Published in The Journal of biological chemistry (05-09-2008)“…TRAF6, a crucial adaptor molecule in innate and adaptive immunity, contains three distinct functional domains. The C-terminal TRAF domain facilitates…”
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Deletion of TAK1 in the myeloid lineage results in the spontaneous development of myelomonocytic leukemia in mice
Published in PloS one (10-12-2012)“…Previous studies of the conditional ablation of TGF-β activated kinase 1 (TAK1) in mice indicate that TAK1 has an obligatory role in the survival and/or…”
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Impact of undiagnosed type 2 diabetes and pre-diabetes on severity and mortality for SARS-CoV-2 infection
Published in BMJ open diabetes research & care (01-02-2021)“…IntroductionDiabetes and hyperglycemia are risk factors for critical COVID-19 outcomes; however, the impact of pre-diabetes and previously unidentified cases…”
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PI3Kγ inhibition circumvents inflammation and vascular leak in SARS-CoV-2 and other infections
Published in Science translational medicine (03-07-2024)“…Virulent infectious agents such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and methicillin-resistant (MRSA) induce tissue damage that…”
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Critical Role of Monoubiquitination of Histone H2AX Protein in Histone H2AX Phosphorylation and DNA Damage Response
Published in The Journal of biological chemistry (02-09-2011)“…DNA damage response is an important surveillance mechanism used to maintain the integrity of the human genome in response to genotoxic stress. Histone variant…”
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Liver Transplantation and Inflammatory Bowel Disease: Breaking Barriers in a Low‐Income Country
Published in Liver transplantation (01-02-2021)Get full text
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Ovine sperm DNA oxidation quantification using an 8‐OHdG immunodetection assay
Published in Reproduction in domestic animals (01-10-2019)“…Our aim was to optimize 8‐hydroxy‐2′‐deoxyguanosine (8‐OHdG) immunodetection in order to detect DNA damage caused by oxidative stress that may not be detected…”
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TAK1-dependent Signaling Requires Functional Interaction with TAB2/TAB3
Published in The Journal of biological chemistry (09-02-2007)“…Transforming growth factor β-activated kinase 1 (TAK1), a member of the MAPKKK family, was initially described to play an essential role in the transforming…”
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