Search Results - "Campolo, Nicolás"

Biochemistry of Peroxynitrite and Protein Tyrosine Nitration by Ferrer-Sueta, Gerardo, Campolo, Nicolás, Trujillo, Madia, Bartesaghi, Silvina, Carballal, Sebastián, Romero, Natalia, Alvarez, Beatriz, Radi, Rafael

“…Peroxynitrite is a short-lived and reactive biological oxidant formed from the diffusion-controlled reaction of the free radicals superoxide (O2 •–) and nitric…”
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3-Nitrotyrosine and related derivatives in proteins: precursors, radical intermediates and impact in function by Campolo, Nicolás, Issoglio, Federico M, Estrin, Darío A, Bartesaghi, Silvina, Radi, Rafael

“…Oxidative post-translational modification of proteins by molecular oxygen (O2)- and nitric oxide (•NO)-derived reactive species is a usual process that occurs…”
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The Effect of Fat Intake with Increased Omega-6-to-Omega-3 Polyunsaturated Fatty Acid Ratio in Animal Models of Early and Late Alzheimer's Disease-like Pathogenesis by Galeano, Pablo, de Ceglia, Marialuisa, Mastrogiovanni, Mauricio, Campanelli, Lorenzo, Medina-Vera, Dina, Campolo, Nicolás, Novack, Gisela V, Rosell-Valle, Cristina, Suárez, Juan, Aicardo, Adrián, Campuzano, Karen, Castaño, Eduardo M, Do Carmo, Sonia, Cuello, A Claudio, Bartesaghi, Silvina, Radi, Rafael, Rodríguez de Fonseca, Fernando, Morelli, Laura

“…This work aims to clarify the effect of dietary polyunsaturated fatty acid (PUFA) intake on the adult brain affected by amyloid pathology. McGill-R-Thy1-APP…”
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Decreased proteasomal cleavage at nitrotyrosine sites in proteins and peptides by Ott, Christiane, Tomasina, Florencia, Campolo, Nicolás, Bartesaghi, Silvina, Mastrogiovanni, Mauricio, Leyva, Alejandro, Batthyány, Carlos, Meinl, Walter, Grune, Tilman, Radi, Rafael

“…Removal of moderately oxidized proteins is mainly carried out by the proteasome, while highly modified proteins are no longer degradable. However, in the case…”
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Multiple oxidative post-translational modifications of human glutamine synthetase mediate peroxynitrite-dependent enzyme inactivation and aggregation by Campolo, Nicolás, Mastrogiovanni, Mauricio, Mariotti, Michele, Issoglio, Federico M., Estrin, Darío, Hägglund, Per, Grune, Tilman, Davies, Michael J., Bartesaghi, Silvina, Radi, Rafael

“…Glutamine synthetase (GS), which catalyzes the ATP-dependent synthesis of L-glutamine from L-glutamate and ammonia, is a ubiquitous and conserved enzyme that…”
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Metal-catalyzed protein tyrosine nitration in biological systems by Campolo, Nicolás, Bartesaghi, Silvina, Radi, Rafael

“…Protein tyrosine nitration is an oxidative postranslational modification that can affect protein structure and function. It is mediated in vivo by the…”
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Oxidative Inactivation of Human Glutamine Synthetase: Defining the Role of Tyrosine Nitration by Haberkorn, Marcela, Campolo, Nicolás, Mastrogiovanni, Mauricio, Bartesaghi, Silvina, Radi, Rafael

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4-Hydroxynonenal impairs miRNA maturation in heart failure via Dicer post-translational modification by Kiyuna, Ligia A, Candido, Darlan S, Bechara, Luiz R G, Jesus, Itamar C G, Ramalho, Lisley S, Krum, Barbara, Albuquerque, Ruda P, Campos, Juliane C, Bozi, Luiz H M, Zambelli, Vanessa O, Alves, Ariane N, Campolo, Nicolás, Mastrogiovanni, Mauricio, Bartesaghi, Silvina, Leyva, Alejandro, Durán, Rosario, Radi, Rafael, Arantes, Guilherme M, Cunha-Neto, Edécio, Mori, Marcelo A, Chen, Che-Hong, Yang, Wenjin, Mochly-Rosen, Daria, MacRae, Ian J, Ferreira, Ludmila R P, Ferreira, Julio C B

“…BACKGROUND AND AIMSDeveloping novel therapies to battle the global public health burden of heart failure remains challenging. This study investigates the…”
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Oxidative Inactivation and Modification of Glutamine synthetase in in vitro models of Alzheimer Disease by Garcimartín, Santiago, Campolo, Nicolás, Haberkorn, Marcela, Mastrogiovanni, Mauricio, Radi, Rafael, Almeida, Ángeles, Esteban, María Delgado, Bartesaghi, Silvina

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Mechanisms of Oxidative Inactivation of Human Glutamine Synthetase by Campolo, Nicolás, Mastrogiovanni, Mauricio, Mariotti, Michele, Davies, Michael, Bartesaghi, Silvina, Radi, Rafael

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Nerve growth factor (NGF) nitration and changes in receptors expression following β-amyloid administration as a murine model of Alzheimer's Disease by Garcimartín, Santiago, Campolo, Nicolás, Mastrogiovanni, Mauricio, Trias, Emiliano, Barbeito, Luis, Esteban, María Delgado, Almeida, Ángeles, Radi, Rafael, Bartesaghi, Silvina

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Peroxynitrite-Mediated Oxidative Modifications of Nerve Growth Factor (NGF) by Bartesaghi, Silvina, Garcimartín, Santiago, Tomasina, Florencia, Campolo, Nicolás, Zeida, Ari, Issoglio, Federico, Trias, Emiliano, Barbeito, Luis, Durán, Rosario, Radi, Rafael

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Decreased proteasome cleavage rates at nitrotyrosine sites in proteins and peptides by Bartesaghi, Silvina, Ott, Cristiane, Tomasina, Florencia, Meinl, Walter, Batthyany, Carlos, Campolo, Nicolás, Bluhm, Martina, Hoffmann, Ralf, Grune, Tilman, Radi, Rafael

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OP-38 - Insights into the mechanisms of peroxynitrite-mediated inactivation of human glutamine synthetase by Bartesaghi, Silvina, Campolo, Nicolás, Mastrogiovanni, Mauricio, Issoglio, Federico, Zeida, Ari, Ott, Christiane, Grune, Tilman, Estrín, Darío, Radi, Rafael

“…Glutamine synthetase (GS) is a key metabolic enzyme that catalyzes the ATP-dependent synthesis of glutamine from glutamate and ammonia. In the CNS, it is…”
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Insights into the mechanisms of peroxynitrite-mediated inactivation of human glutamine synthetase by Bartesaghi, Silvina, Campolo, Nicolás, Mastrogiovanni, Mauricio, Issoglio, Federico, Zeida, Ari, Ott, Christiane, Grune, Tilman, Estrín, Darío, Radi, Rafael

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2 - Oxidative Inactivation of Human Glutamine Synthetase: Biochemical and Computational Studies by Bartesaghi, Silvina, Campolo, Nicolás, Issoglio, Federico, Zeida, Ari, Grune, Tilman, Estrín, Darío, Radi, Rafael

“…Glutamine synthetase (GS) is a key metabolic enzyme that catalyzes the ATP-dependent synthesis of glutamine from glutamate and ammonia. In the central nervous…”
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Oxidative Inactivation of Human Glutamine Synthetase: Biochemical and Computational Studies by Bartesaghi, Silvina, Campolo, Nicolás, Issoglio, Federico, Zeida, Ari, Grune, Tilman, Estrín, Darío, Radi, Rafael

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PP33 - Impact of tyrosine nitration on cellular glutamine synthetase turnover and functionality by Ott, Christiane, Hugo-Pereira, Martin, Meinl, Walter, Campolo, Nicolás, Bartesaghi, Silvina, Radi, Rafael, Grune, Tilman

“…During oxidative damage to proteins by reactive nitrogen species (RNS), post-translational modifications can lead to dysfunctional proteins and promote their…”
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Impact of tyrosine nitration on cellular glutamine synthetase turnover and functionality by Ott, Christiane, Hugo-Pereira, Martin, Meinl, Walter, Campolo, Nicolás, Bartesaghi, Silvina, Radi, Rafael, Grune, Tilman

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Exploring the Catalytic Mechanism of Human Glutamine Synthetase by Computer Simulations by Issoglio, Federico M, Campolo, Nicolas, Zeida, Ari, Grune, Tilman, Radi, Rafael, Estrin, Dario A, Bartesaghi, Silvina

“…Glutamine synthetase is an important enzyme that catalyzes the ATP-dependent formation of glutamine from glutamate and ammonia. In mammals, it plays a key role…”
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