Impact of body mass index on the circulating levels of nitric oxide metabolites in clinicopathological features from women with breast cancer

Impact of body mass index on the circulating levels of nitric oxide metabolites in clinicopathological features from women with breast cancer

To investigate the clinical meaning of systemic nitric oxide metabolites (NOx) by comparing eutrophic and overweight/obese patients with breast cancer, considering clinical factors determinant of disease prognosis. A total of 61 women diagnosed with breast cancer were included in the study. NOx esti...

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Bibliographic Details
Published in:Precision medical sciences Vol. 12; no. 2; pp. 62 - 68
Main Authors: Ferreira Fagotti, Pâmella Aparecida, Oliveira Colleto, Matheus Iago, Okamoto Ferreira, Mariane, Teixeira Maito, Vitor, Campestrini, Bruno Vinicius, Scandolara, Thalita Basso, Souza, Janoário Athanázio, Rech, Daniel, Silva, Janaína Carla, Alves, Fernanda Mara, Jacob Victorino, Vanessa, Venturini, Danielle, Panis, Carolina
Format: Journal Article
Language:English
Published: Melbourne John Wiley & Sons Australia, Ltd 01-06-2023
John Wiley & Sons, Inc
Wiley
Subjects:
Body mass index
Breast cancer
Comparative analysis
Disease
Epidermal growth factor
Estrogens
Inflammation
Lymphatic system
Medical prognosis
Menopause
Metabolites
Metastasis
Nitric oxide
nitric oxide metabolites
Obesity
Overweight
Tumor necrosis factor-TNF
Tumors
Variance analysis
Womens health
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Summary:To investigate the clinical meaning of systemic nitric oxide metabolites (NOx) by comparing eutrophic and overweight/obese patients with breast cancer, considering clinical factors determinant of disease prognosis. A total of 61 women diagnosed with breast cancer were included in the study. NOx estimative was performed on plasma samples using the cadmium–copper‐Griess method. It was then categorized according to the age at diagnosis, body mass index, menopausal status, tumor histological features, molecular subtype lymph nodal invasion, and emboli presence, considering p ≤ 0.05 as significant. A significant augment was observed in NOx levels from overweight patients carrying Luminal B tumors concerning the Luminal B eutrophic ones. There was a considerable reduction in NOx levels in eutrophic postmenopausal patients compared to the overweight postmenopausal ones. Patients bearing tumor sizes between 2 and 5 cm in the eutrophic group had lower levels of NOx, concerning the overweight patients carrying tumors of the same size interval. Circulating NOx levels change significantly according to the trophic‐adipose status of breast cancer patients, and it is further affected by prognostic factors related to poor disease prognosis. Breast cancer patients with excessive body fat produce more nitric acid metabolites (NOx) than eutrophic patients. Circulating NOx levels are altered in overweight breast cancer women with more aggressive diseases, such as luminal B subtype tumors and larger tumors.
Bibliography:All authors equally contributed to the study.
ISSN:2642-2514
2642-2514
DOI:10.1002/prm2.12104