Search Results - "Campbell, Robert A."

Role of Platelets in Detection and Regulation of Infection by Portier, Irina, Campbell, Robert A.

“…Platelets are classically known as essential mediators of hemostasis and thrombosis. However, in recent years, platelets have gained recognition for their…”
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The logic of single-cell projections from visual cortex by Han, Yunyun, Kebschull, Justus M., Campbell, Robert A. A., Cowan, Devon, Imhof, Fabia, Zador, Anthony M., Mrsic-Flogel, Thomas D.

“…Neocortical areas communicate through extensive axonal projections, but the logic of information transfer remains poorly understood, because the projections of…”
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Neutrophil extracellular traps regulate ischemic stroke brain injury by Denorme, Frederik, Portier, Irina, Rustad, John L, Cody, Mark J, de Araujo, Claudia V, Hoki, Chieko, Alexander, Matthew D, Grandhi, Ramesh, Dyer, Mitchell R, Neal, Matthew D, Majersik, Jennifer J, Yost, Christian C, Campbell, Robert A

“…Ischemic stroke prompts a strong inflammatory response, which is associated with exacerbated outcomes. In this study, we investigated mechanistic regulators of…”
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Neutrophil extracellular traps contribute to immunothrombosis in COVID-19 acute respiratory distress syndrome by Middleton, Elizabeth A., He, Xue-Yan, Denorme, Frederik, Campbell, Robert A., Ng, David, Salvatore, Steven P., Mostyka, Maria, Baxter-Stoltzfus, Amelia, Borczuk, Alain C., Loda, Massimo, Cody, Mark J., Manne, Bhanu Kanth, Portier, Irina, Harris, Estelle S., Petrey, Aaron C., Beswick, Ellen J., Caulin, Aleah F., Iovino, Anthony, Abegglen, Lisa M., Weyrich, Andrew S., Rondina, Matthew T., Egeblad, Mikala, Schiffman, Joshua D., Yost, Christian Con

“…COVID-19 affects millions of patients worldwide, with clinical presentation ranging from isolated thrombosis to acute respiratory distress syndrome (ARDS)…”
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Cytokine release syndrome in COVID‐19: Innate immune, vascular, and platelet pathogenic factors differ in severity of disease and sex by Petrey, Aaron C., Qeadan, Fares, Middleton, Elizabeth A., Pinchuk, Irina V., Campbell, Robert A., Beswick, Ellen J.

“…COVID‐19 rapidly emerged as a crippling public health crisis in the last few months, which has presented a series health risk. Understanding of the immune…”
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Sepsis alters the transcriptional and translational landscape of human and murine platelets by Middleton, Elizabeth A., Rowley, Jesse W., Campbell, Robert A., Grissom, Colin K., Brown, Samuel M., Beesley, Sarah J., Schwertz, Hansjörg, Kosaka, Yasuhiro, Manne, Bhanu K., Krauel, Krystin, Tolley, Neal D., Eustes, Alicia S., Guo, Li, Paine, Robert, Harris, Estelle S., Zimmerman, Guy A., Weyrich, Andrew S., Rondina, Matthew T.

“…There is increasing recognition that platelets have a functional role in the pathophysiology of sepsis, though this role has not been precisely defined…”
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Human megakaryocytes possess intrinsic antiviral immunity through regulated induction of IFITM3 by Campbell, Robert A., Schwertz, Hansjorg, Hottz, Eugenio D., Rowley, Jesse W., Manne, Bhanu Kanth, Washington, A. Valance, Hunter-Mellado, Robert, Tolley, Neal D., Christensen, Miles, Eustes, Alicia S., Montenont, Emilie, Bhatlekar, Seema, Ventrone, Cassandra H., Kirkpatrick, Beth D., Pierce, Kristen K., Whitehead, Stephen S., Diehl, Sean A., Bray, Paul F., Zimmerman, Guy A., Kosaka, Yasuhiro, Bozza, Patricia T., Bozza, Fernando A., Weyrich, Andrew S., Rondina, Matthew T.

“…Evolving evidence indicates that platelets and megakaryocytes (MKs) have unexpected activities in inflammation and infection; whether viral infections…”
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Advanced age results in a diminished endothelial glycocalyx by Machin, Daniel R, Bloom, Samuel I, Campbell, Robert A, Phuong, Tam T T, Gates, Phillip E, Lesniewski, Lisa A, Rondina, Matthew T, Donato, Anthony J

“…Age-related microvascular dysfunction is well characterized in rodents and humans, but little is known about the properties of the microvascular endothelial…”
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Catch per unit effort standardization using spatio-temporal models for Australia’s Eastern Tuna and Billfish Fishery by Zhou, Shijie, Campbell, Robert A, Hoyle, Simon D

“…Abstract The majority of catch per unit effort (cpue) standardizations use generalized linear models (GLMs) or generalized additive models (GAMs). We develop…”
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Cationic PAMAM Dendrimers Aggressively Initiate Blood Clot Formation by Jones, Clinton F, Campbell, Robert A, Brooks, Amanda E, Assemi, Shoeleh, Tadjiki, Soheyl, Thiagarajan, Giridhar, Mulcock, Cheyanne, Weyrich, Andrew S, Brooks, Benjamin D, Ghandehari, Hamidreza, Grainger, David W

“…Poly(amidoamine) (PAMAM) dendrimers are increasingly studied as model nanoparticles for a variety of biomedical applications, notably in systemic…”
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Adaptation and Evolution of Biological Materials by Campbell, Robert A, Dean, Mason N

“…Abstract Research into biological materials often centers on the impressive material properties produced in Nature. In the process, however, this research…”
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Neonatal NET-inhibitory factor and related peptides inhibit neutrophil extracellular trap formation by Yost, Christian C, Schwertz, Hansjörg, Cody, Mark J, Wallace, Jared A, Campbell, Robert A, Vieira-de-Abreu, Adriana, Araujo, Claudia V, Schubert, Sebastian, Harris, Estelle S, Rowley, Jesse W, Rondina, Matthew T, Fulcher, James M, Koening, Curry L, Weyrich, Andrew S, Zimmerman, Guy A

“…Neutrophil granulocytes, also called polymorphonuclear leukocytes (PMNs), extrude molecular lattices of decondensed chromatin studded with histones, granule…”
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The mesoSPIM initiative: open-source light-sheet microscopes for imaging cleared tissue by Voigt, Fabian F., Kirschenbaum, Daniel, Platonova, Evgenia, Pagès, Stéphane, Campbell, Robert A. A., Kastli, Rahel, Schaettin, Martina, Egolf, Ladan, van der Bourg, Alexander, Bethge, Philipp, Haenraets, Karen, Frézel, Noémie, Topilko, Thomas, Perin, Paola, Hillier, Daniel, Hildebrand, Sven, Schueth, Anna, Roebroeck, Alard, Roska, Botond, Stoeckli, Esther T., Pizzala, Roberto, Renier, Nicolas, Zeilhofer, Hanns Ulrich, Karayannis, Theofanis, Ziegler, Urs, Batti, Laura, Holtmaat, Anthony, Lüscher, Christian, Aguzzi, Adriano, Helmchen, Fritjof

“…Light-sheet microscopy is an ideal technique for imaging large cleared samples; however, the community is still lacking instruments capable of producing…”
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Plasma-Assisted Large-Scale Nanoassembly of Metal–Insulator Bioplasmonic Mushrooms by Bhalla, Nikhil, Sathish, Shivani, Galvin, Casey J, Campbell, Robert A, Sinha, Abhishek, Shen, Amy Q

“…Large-scale plasmonic substrates consisting of metal–insulator nanostructures coated with a biorecognition layer can be exploited for enhanced label-free…”
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Integrating indigenous livelihood and lifestyle objectives in managing a natural resource by Plagányi, Éva Elizabeth, van Putten, Ingrid, Hutton, Trevor, Deng, Roy A., Dennis, Darren, Pascoe, Sean, Skewes, Tim, Campbell, Robert A.

“…Evaluating the success of natural resource management approaches requires methods to measure performance against biological, economic, social, and governance…”
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IFITM3 regulates fibrinogen endocytosis and platelet reactivity in nonviral sepsis by Campbell, Robert A, Manne, Bhanu Kanth, Banerjee, Meenakshi, Middleton, Elizabeth A, Ajanel, Abigail, Schwertz, Hansjorg, Denorme, Frederik, Stubben, Chris, Montenont, Emilie, Saperstein, Samantha, Page, Lauren, Tolley, Neal D, Lim, Diana L, Brown, Samuel M, Grissom, Colin K, Sborov, Douglas W, Krishnan, Anandi, Rondina, Matthew T

“…Platelets and megakaryocytes are critical players in immune responses. Recent reports suggest infection and inflammation alter the megakaryocyte and platelet…”
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RASA3 is a critical inhibitor of RAP1-dependent platelet activation by Stefanini, Lucia, Paul, David S, Robledo, Raymond F, Chan, E Ricky, Getz, Todd M, Campbell, Robert A, Kechele, Daniel O, Casari, Caterina, Piatt, Raymond, Caron, Kathleen M, Mackman, Nigel, Weyrich, Andrew S, Parrott, Matthew C, Boulaftali, Yacine, Adams, Mark D, Peters, Luanne L, Bergmeier, Wolfgang

“…The small GTPase RAP1 is critical for platelet activation and thrombus formation. RAP1 activity in platelets is controlled by the GEF CalDAG-GEFI and an…”
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Novel anti-bacterial activities of β-defensin 1 in human platelets: suppression of pathogen growth and signaling of neutrophil extracellular trap formation by Kraemer, Bjoern F, Campbell, Robert A, Schwertz, Hansjörg, Cody, Mark J, Franks, Zechariah, Tolley, Neal D, Kahr, Walter H A, Lindemann, Stephan, Seizer, Peter, Yost, Christian C, Zimmerman, Guy A, Weyrich, Andrew S

“…Human β-defensins (hBD) are antimicrobial peptides that curb microbial activity. Although hBD's are primarily expressed by epithelial cells, we show that human…”
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The predominant PAR4 variant in individuals of African ancestry worsens murine and human stroke outcomes by Denorme, Frederik, Armstrong, Nicole D, Stoller, Michelle L, Portier, Irina, Tugolukova, Emilia A, Tanner, Rikki M, Montenont, Emilie, Bhatlekar, Seema, Cody, Mark, Rustad, John L, Ajanel, Abigail, Tolley, Neal D, Murray, Darian C, Boyle, Julie L, Nieman, Marvin T, McKenzie, Steven E, Yost, Christian Con, Lange, Leslie A, Cushman, Mary, Irvin, Marguerite R, Bray, Paul F, Campbell, Robert A

“…Protease-activated receptor 4 (PAR4) (gene F2RL3) harbors a functional dimorphism, rs773902 A/G (encoding Thr120/Ala120, respectively) and is associated with…”
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Homogeneous surrogate virus neutralization assay to rapidly assess neutralization activity of anti-SARS-CoV-2 antibodies by Kim, Sun Jin, Yao, Zhong, Marsh, Morgan C., Eckert, Debra M., Kay, Michael S., Lyakisheva, Anna, Pasic, Maria, Bansal, Aiyush, Birnboim, Chaim, Jha, Prabhat, Galipeau, Yannick, Langlois, Marc-André, Delgado, Julio C., Elgort, Marc G., Campbell, Robert A., Middleton, Elizabeth A., Stagljar, Igor, Owen, Shawn C.

“…The COVID-19 pandemic triggered the development of numerous diagnostic tools to monitor infection and to determine immune response. Although assays to measure…”
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