Search Results - "Campbell, Kenneth S."

MyoVision: software for automated high-content analysis of skeletal muscle immunohistochemistry by Wen, Yuan, Murach, Kevin A, Vechetti, Jr, Ivan J, Fry, Christopher S, Vickery, Chase, Peterson, Charlotte A, McCarthy, John J, Campbell, Kenneth S

“…Analysis of skeletal muscle cross sections is an important experimental technique in muscle biology. Many aspects of immunohistochemistry and fluorescence…”
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A short history of the development of mathematical models of cardiac mechanics by Niederer, Steven A., Campbell, Kenneth S., Campbell, Stuart G.

“…Cardiac mechanics plays a crucial role in atrial and ventricular function, in the regulation of growth and remodelling, in the progression of disease, and the…”
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Cardiac myosin binding protein-C phosphorylation as a function of multiple protein kinase and phosphatase activities by Kampourakis, Thomas, Ponnam, Saraswathi, Campbell, Kenneth S., Wellette-Hunsucker, Austin, Koch, Daniel

“…Phosphorylation of cardiac myosin binding protein-C (cMyBP-C) is a determinant of cardiac myofilament function. Although cMyBP-C phosphorylation by various…”
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Compliance Accelerates Relaxation in Muscle by Allowing Myosin Heads to Move Relative to Actin by Campbell, Kenneth S.

“…The mechanisms that limit the speed at which striated muscles relax are poorly understood. This work presents, to our knowledge, novel simulations that show…”
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Integrated multi-omic characterization of congenital heart disease by Hill, Matthew C., Kadow, Zachary A., Long, Hali, Morikawa, Yuka, Martin, Thomas J., Birks, Emma J., Campbell, Kenneth S., Nerbonne, Jeanne, Lavine, Kory, Wadhwa, Lalita, Wang, Jun, Turaga, Diwakar, Adachi, Iki, Martin, James F.

“…The heart, the first organ to develop in the embryo, undergoes complex morphogenesis that when defective results in congenital heart disease (CHD). With…”
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Effective fiber hypertrophy in satellite cell-depleted skeletal muscle by McCarthy, John J, Mula, Jyothi, Miyazaki, Mitsunori, Erfani, Rod, Garrison, Kelcye, Farooqui, Amreen B, Srikuea, Ratchakrit, Lawson, Benjamin A, Grimes, Barry, Keller, Charles, Van Zant, Gary, Campbell, Kenneth S, Esser, Karyn A, Dupont-Versteegden, Esther E, Peterson, Charlotte A

“…An important unresolved question in skeletal muscle plasticity is whether satellite cells are necessary for muscle fiber hypertrophy. To address this issue, a…”
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Diverse and complex muscle spindle afferent firing properties emerge from multiscale muscle mechanics by Blum, Kyle P, Campbell, Kenneth S, Horslen, Brian C, Nardelli, Paul, Housley, Stephen N, Cope, Timothy C, Ting, Lena H

“…Despite decades of research, we lack a mechanistic framework capable of predicting how movement-related signals are transformed into the diversity of muscle…”
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Discovery of novel cardiac troponin activators using fluorescence polarization-based high throughput screening assays by Parijat, Priyanka, Ponnam, Saraswathi, Attili, Seetharamaiah, Campbell, Kenneth S., El-Mezgueldi, Mohammed, Pfuhl, Mark, Kampourakis, Thomas

“…The large unmet demand for new heart failure therapeutics is widely acknowledged. Over the last decades the contractile myofilaments themselves have emerged as…”
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Diabetic microcirculatory disturbances and pathologic erythropoiesis are provoked by deposition of amyloid-forming amylin in red blood cells and capillaries by Verma, Nirmal, Liu, Miao, Ly, Han, Loria, Analia, Campbell, Kenneth S, Bush, Heather, Kern, Philip A, Jose, Pedro A, Taegtmeyer, Heinrich, Bers, Donald M, Despa, Sanda, Goldstein, Larry B, Murray, Andrew J, Despa, Florin

“…In the setting of type-2 diabetes, there are declines of structural stability and functionality of blood capillaries and red blood cells (RBCs), increasing the…”
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Cardiac myosin regulatory light chain kinase modulates cardiac contractility by phosphorylating both myosin regulatory light chain and troponin I by Sevrieva, Ivanka R., Brandmeier, Birgit, Ponnam, Saraswathi, Gautel, Mathias, Irving, Malcolm, Campbell, Kenneth S., Sun, Yin-Biao, Kampourakis, Thomas

“…Heart muscle contractility and performance are controlled by posttranslational modifications of sarcomeric proteins. Although myosin regulatory light chain…”
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CLOCK and BMAL1 regulate MyoD and are necessary for maintenance of skeletal muscle phenotype and function by Andrews, Jessica L., Zhang, Xiping, McCarthy, John J., McDearmon, Erin L., Hornberger, Troy A., Russell, Brenda, Campbell, Kenneth S., Arbogast, Sandrine, Reid, Michael B., Walker, John R., Hogenesch, John B., Takahashi, Joseph S., Esser, Karyn A.

“…MyoD, a master regulator of myogenesis, exhibits a circadian rhythm in its mRNA and protein levels, suggesting a possible role in the daily maintenance of…”
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Computational analysis of ventricular mechanics in hypertrophic cardiomyopathy patients by Mojumder, Joy, Fan, Lei, Nguyen, Thuy, Campbell, Kenneth S., Wenk, Jonathan F., Guccione, Julius M., Abraham, Theodore, Lee, Lik Chuan

“…Hypertrophic cardiomyopathy (HCM) is a genetic heart disease that is associated with many pathological features, such as a reduction in global longitudinal…”
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MgADP Promotes Myosin Head Movement toward Actin at Low [Ca2+] to Increase Force Production and Ca2+-Sensitivity of Contraction in Permeabilized Porcine Myocardial Strips by Awinda, Peter O., Ma, Weikang, Turner, Kyrah L., Zhao, Jing, Gong, Henry, Thompson, Mindy S., Campbell, Kenneth S., Irving, Thomas C., Tanner, Bertrand C. W.

“…Myosin cross-bridges dissociate from actin following Mg2+-adenosine triphosphate (MgATP) binding. Myosin hydrolyses MgATP into inorganic phosphate (Pi) and…”
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Interactions between connected half-sarcomeres produce emergent mechanical behavior in a mathematical model of muscle by Campbell, Kenneth S

“…Most reductionist theories of muscle attribute a fiber's mechanical properties to the scaled behavior of a single half-sarcomere. Mathematical models of this…”
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Multiscale Modeling of Cardiovascular Function Predicts That the End-Systolic Pressure Volume Relationship Can Be Targeted via Multiple Therapeutic Strategies by Campbell, Kenneth S, Chrisman, Brianna Sierra, Campbell, Stuart G

“…Most patients who develop heart failure are unable to elevate their cardiac output on demand due to impaired contractility and/or reduced ventricular filling…”
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Detection of Parvovirus B19 genome in human heart tissue samples by Kloc, Anna, Campbell, Kenneth S, Espinoza, Yarida A. Urbina

“…Abstract Objective Identifying viral genomes in human heart tissues is critical for disease diagnosis and assessment of cardiovascular damage. Human heart…”
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Effect of the Novel Myotrope Danicamtiv on Cross-Bridge Behavior in Human Myocardium by Choi, Joohee, Holmes, Joshua B, Campbell, Kenneth S, Stelzer, Julian E

“…Background Omecamtiv mecarbil (OM) and danicamtiv both increase myocardial force output by selectively activating myosin within the cardiac sarcomere. Enhanced…”
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Dynamic but discordant alterations in zDHHC5 expression and palmitoylation of its substrates in cardiac pathologies by Main, Alice, Boguslavskyi, Andri, Howie, Jacqueline, Kuo, Chien-Wen, Rankin, Aileen, Burton, Francis L, Smith, Godfrey L, Hajjar, Roger, Baillie, George S, Campbell, Kenneth S, Shattock, Michael J, Fuller, William

“…S-palmitoylation is an essential lipid modification catalysed by zDHHC-palmitoyl acyltransferases that regulates the localisation and activity of substrates in…”
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Distinct growth hormone receptor signaling modes regulate skeletal muscle development and insulin sensitivity in mice by Mavalli, Mahendra D, DiGirolamo, Douglas J, Fan, Yong, Riddle, Ryan C, Campbell, Kenneth S, van Groen, Thomas, Frank, Stuart J, Sperling, Mark A, Esser, Karyn A, Bamman, Marcas M, Clemens, Thomas L

“…Skeletal muscle development, nutrient uptake, and nutrient utilization is largely coordinated by growth hormone (GH) and its downstream effectors, in…”
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Regulation of Myofilament Contractile Function in Human Donor and Failing Hearts by McDonald, Kerry S, Hanft, Laurin M, Robinett, Joel C, Guglin, Maya, Campbell, Kenneth S

“…Heart failure (HF) often includes changes in myocardial contractile function. This study addressed the myofibrillar basis for contractile dysfunction in…”
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