Search Results - "Campbell, Jabbar"

The C-terminal domains of NF-H and NF-M subunits maintain axonal neurofilament content by blocking turnover of the stationary neurofilament network by Rao, Mala V, Yuan, Aidong, Campbell, Jabbar, Kumar, Asok, Nixon, Ralph A

“…Newly synthesized neurofilaments or protofilaments are incorporated into a highly stable stationary cytoskeleton network as they are transported along axons…”
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Marked Calpastatin (CAST) Depletion in Alzheimer's Disease Accelerates Cytoskeleton Disruption and Neurodegeneration: Neuroprotection by CAST Overexpression by Rao, Mala V, Mohan, Panaiyur S, Peterhoff, Corrinne M, Yang, Dun-Sheng, Schmidt, Stephen D, Stavrides, Philip H, Campbell, Jabbar, Chen, Yuanxin, Jiang, Ying, Paskevich, Peter A, Cataldo, Anne M, Haroutunian, Vahram, Nixon, Ralph A

“…Increased activity of calpains is implicated in synaptic dysfunction and neurodegeneration in Alzheimer's disease (AD). The molecular mechanisms responsible…”
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Calpastatin inhibits motor neuron death and increases survival of hSOD1G93A mice by Rao, Mala V., Campbell, Jabbar, Palaniappan, Arti, Kumar, Asok, Nixon, Ralph A.

“…Amyotrophic lateral sclerosis (ALS) is a progressive motor neuron disease with a poorly understood cause and no effective treatment. Given that calpains…”
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The myosin Va head domain binds to the neurofilament-L rod and modulates endoplasmic reticulum (ER) content and distribution within axons by Rao, Mala V, Mohan, Panaiyur S, Kumar, Asok, Yuan, Aidong, Montagna, Lee, Campbell, Jabbar, Veeranna, Espreafico, Enilza M, Julien, Jean P, Nixon, Ralph A

“…The neurofilament light subunit (NF-L) binds to myosin Va (Myo Va) in neurons but the sites of interaction and functional significance are not clear. We show…”
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Calpastatin inhibits motor neuron death and increases survival of hSOD1(G93A) mice by Rao, Mala V, Campbell, Jabbar, Palaniappan, Arti, Kumar, Asok, Nixon, Ralph A

“…Amyotrophic lateral sclerosis (ALS) is a progressive motor neuron disease with a poorly understood cause and no effective treatment. Given that calpains…”
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Emerging siRNA Design Principles and Consequences for Biotransformation and Disposition in Drug Development by Humphreys, Sara C, Thayer, Mai B, Campbell, Jabbar, Chen, Wen Li Kelly, Adams, Dan, Lade, Julie M, Rock, Brooke M

“…After two decades teetering at the intersection of laboratory tool and therapeutic reality, with two siRNA drugs now clinically approved, this modality has…”
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Specific calpain inhibition by calpastatin prevents tauopathy and neurodegeneration and restores normal lifespan in tau P301L mice by Rao, Mala V, McBrayer, Mary Kate, Campbell, Jabbar, Kumar, Asok, Hashim, Audrey, Sershen, Henry, Stavrides, Philip H, Ohno, Masuo, Hutton, Michael, Nixon, Ralph A

“…Tau pathogenicity in Alzheimer's disease and other tauopathies is thought to involve the generation of hyperphosphorylated, truncated, and oligomeric tau…”
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Calpastatin inhibits motor neuron death and increases survival of hSOD1 super(G93A) mice by Rao, Mala V, Campbell, Jabbar, Palaniappan, Arti, Kumar, Asok, Nixon, Ralph A

“…Amyotrophic lateral sclerosis (ALS) is a progressive motor neuron disease with a poorly understood cause and no effective treatment. Given that calpains…”
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Calpastatin inhibits motor neuron death and increases survival of hSOD1 G93A mice by Rao, Mala V., Campbell, Jabbar, Palaniappan, Arti, Kumar, Asok, Nixon, Ralph A.

“…Abstract Amyotrophic lateral sclerosis (ALS) is a progressive motor neuron disease with a poorly understood cause and no effective treatment. Given that…”
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The Neurofilament Middle Molecular Mass Subunit Carboxyl-Terminal Tail Domains Is Essential for the Radial Growth and Cytoskeletal Architecture of Axons but Not for Regulating Neurofilament Transport Rate by Rao, Mala V., Campbell, Jabbar, Yuan, Aidong, Kumar, Asok, Gotow, Takahiro, Uchiyama, Yasuo, Nixon, Ralph A.

“…The phosphorylated carboxyl-terminal "tail" domains of the neurofilament (NF) subunits, NF heavy (NF-H) and NF medium (NF-M) subunits, have been proposed to…”
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The Myosin Va Head Domain Binds to the Neurofilament-L Rod and Modulates Endoplasmic Reticulum by Rao, Mala V, Mohan, Panaiyur S, Kumar, Asok, Yuan, Aidong, Montagna, Lee, Campbell, Jabbar, Veeranna, Espreafico, Enilza M, Julien, Jean P, Nixon, Ralph A

“…The neurofilament light subunit (NF-L) binds to myosin Va (Myo Va) in neurons but the sites of interaction and functional significance are not clear. We show…”
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The neurofilament middle molecular mass subunit carboxyl-terminal tail domains is essential for the radial growth and cytoskeletal architecture of axons but not for regulating neurofilament by Rao, Mala V, Campbell, Jabbar, Yuan, Aidong, Kumar, Asok

“…The phosphorylated carboxyl-terminal "tail" domains of the neurofilament (NF) subunits, NF heavy (NF-H) and NF medium (NF-M) subunits, have been proposed to…”
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