Trisomy 4 in acute nonlymphocytic leukemia. Report of two cases and review of the literature

Two patients with M2 subtype of acute nonlymphocytic leukemia (ANLL) and trisomy 4 as a primary karyotype change are described. The abnormality was observed in 100% of bone marrow (BM) metaphases in both cases. It appeared alone in one case and was associated with trisomy 13 in 94% of metaphases in...

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Bibliographic Details
Published in:	Cancer genetics and cytogenetics Vol. 60; no. 2; p. 195
Main Authors:	Donti, E, Maccari, A, Tabilio, A, Ardisia, C, Campanari, N, Donti, G V
Format:	Journal Article
Language:	English
Published:	United States 1992
Subjects:	Aged Chromosomes, Human, Pair 4 Female Humans Leukemia, Myeloid, Acute - genetics Male Middle Aged Trisomy Tumor Cells, Cultured
Online Access:	Get more information
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Summary:	Two patients with M2 subtype of acute nonlymphocytic leukemia (ANLL) and trisomy 4 as a primary karyotype change are described. The abnormality was observed in 100% of bone marrow (BM) metaphases in both cases. It appeared alone in one case and was associated with trisomy 13 in 94% of metaphases in the other. These are the second and third cases of ANLL with trisomy 4 documented in Italy. Neither patient appears to have incurred any environmental or therapeutic insult.
ISSN:	0165-4608
DOI:	10.1016/0165-4608(92)90018-4