Search Results - "Campana, Wendy M"

LRP1 deficiency in microglia blocks neuro‐inflammation in the spinal dorsal horn and neuropathic pain processing by Brifault, Coralie, Kwon, HyoJun, Campana, Wendy M., Gonias, Steven L.

“…Following injury to the peripheral nervous system (PNS), microglia in the spinal dorsal horn (SDH) become activated and contribute to the development of local…”
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Tissue-type plasminogen activator regulates macrophage activation and innate immunity by Mantuano, Elisabetta, Azmoon, Pardis, Brifault, Coralie, Banki, Michael A., Gilder, Andrew S., Campana, Wendy M., Gonias, Steven L.

“…Tissue-type plasminogen activator (tPA) is the major intravascular activator of fibrinolysis and a ligand for receptors involved in cell signaling. In cultured…”
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Schwann cell extracellular vesicles: judging a book by its cover by Gonias, Steven, Campana, Wendy

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Activation of p38 mitogen‐activated protein kinase in spinal microglia is a critical link in inflammation‐induced spinal pain processing by Svensson, Camilla I., Marsala, Martin, Westerlund, Anna, Calcutt, Nigel A., Campana, Wendy M., Freshwater, Jason D., Catalano, Rosanne, Feng, Ying, Protter, Andrew A., Scott, Brian, Yaksh, Tony L.

“…We examined the effect of p38 mitogen‐activated protein kinase (MAPK) inhibitors in models of nociception and correlated this effect with localization and…”
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α1‐Antitrypsin derived SP16 peptide demonstrates efficacy in rodent models of acute and neuropathic pain by Wang, Zixuan, Martellucci, Stefano, Van Enoo, Alicia, Austin, Dana, Gelber, Cohava, Campana, Wendy M.

“…SP16 is an innovative peptide derived from the carboxyl‐terminus of α1‐Antitrypsin (AAT), corresponding to residues 364‐380, and contains recognition sequences…”
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A Soluble PrPC Derivative and Membrane-Anchored PrPC in Extracellular Vesicles Attenuate Innate Immunity by Engaging the NMDA-R/LRP1 Receptor Complex by Mantuano, Elisabetta, Azmoon, Pardis, Banki, Michael A., Sigurdson, Christina J., Campana, Wendy M., Gonias, Steven L.

“…Abstract Nonpathogenic cellular prion protein (PrPC) demonstrates anti-inflammatory activity; however, the responsible mechanisms are incompletely defined…”
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Binding and Activation of LRP1-Dependent Cell Signaling in Schwann Cells Using a Peptide Derived from the Hemopexin Domain of MMP‑9 by Kim, John H., Shivkumar, Aashish, Norimoto, Masaki, Castro Lingl, Sascha, Seitz, Christian, Amaro, Rommie E., Gonias, Steve L., Yang, Jerry, Campana, Wendy M.

“…Schwann cells (SCs) undergo phenotypic transformation and then orchestrate nerve repair following a peripheral nervous system injury. The low-density…”
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Deletion of the Gene Encoding the NMDA Receptor GluN1 Subunit in Schwann Cells Causes Ultrastructural Changes in Remak Bundles and Hypersensitivity in Pain Processing by Brifault, Coralie, Romero, Haylie, Van-Enoo, Alicia, Pizzo, Don, Azmoon, Pardis, Kwon, HyoJun, Nasamran, Chanond, Gonias, Steven L, Campana, Wendy M

“…Abnormalities in interactions between sensory neurons and Schwann cells (SCs) may result in heightened pain processing and chronic pain states. We previously…”
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Cellular prion protein in human plasma–derived extracellular vesicles promotes neurite outgrowth via the NMDA receptor–LRP1 receptor system by Gonias, Steven L., Banki, Michael A., Azmoon, Pardis, Romero, Haylie K., Sigurdson, Christina J., Mantuano, Elisabetta, Campana, Wendy M.

“…Exosomes and other extracellular vesicles (EVs) participate in cell–cell communication. Herein, we isolated EVs from human plasma and demonstrated that these…”
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Tumor necrosis factor receptor‐1 is selectively sequestered into Schwann cell extracellular vesicles where it functions as a TNFα decoy by Sadri, Mahrou, Hirosawa, Naoya, Le, Jasmine, Romero, Haylie, Martellucci, Stefano, Kwon, Hyo Jun, Pizzo, Donald, Ohtori, Seiji, Gonias, Steven L., Campana, Wendy M.

“…Schwann cells (SCs) are known to produce extracellular vesicles (EV) that participate in cell–cell communication by transferring cargo to target cells,…”
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Hierarchically Ordered Porous and High-Volume Polycaprolactone Microchannel Scaffolds Enhanced Axon Growth in Transected Spinal Cords by Shahriari, Dena, Koffler, Jacob Y, Tuszynski, Mark H, Campana, Wendy M, Sakamoto, Jeff S

“…The goal of this work was to design nerve guidance scaffolds with a unique architecture to maximize the open volume available for nerve growth…”
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Peripheral nerve injury and sensitization underlie pain associated with oral cancer perineural invasion by Salvo, Elizabeth, Campana, Wendy M., Scheff, Nicole N., Nguyen, Tu Huu, Jeong, Se-hee, Wall, Ian, Wu, Angie K., Zhang, Susanna, Kim, Hyesung, Bhattacharya, Aditi, Janal, Malvin N., Liu, Cheng, Albertson, Donna G., Schmidt, Brian L., Dolan, John C., Schmidt, Robert E., Boada, M. Danilo, Ye, Yi

“…Cancer invading into nerves, termed perineural invasion (PNI), is associated with pain. Here, we show that oral cancer patients with PNI report greater…”
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Axon‐derived PACSIN1 binds to the Schwann cell survival receptor, LRP1, and transactivates TrkC to promote gliatrophic activities by Martellucci, Stefano, Flütsch, Andreas, Carter, Mark, Norimoto, Masaki, Pizzo, Donald, Mantuano, Elisabetta, Sadri, Mahrou, Wang, Zixuan, Chillin‐Fuentes, Daisy, Rosenthal, Sara Brin, Azmoon, Pardis, Gonias, Steven L., Campana, Wendy M.

“…Schwann cells (SCs) undergo phenotypic transformation and then orchestrate nerve repair following PNS injury. The ligands and receptors that activate and…”
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Schwann cells regulate sensory neuron gene expression before and after peripheral nerve injury by Poplawski, Gunnar, Ishikawa, Tetsuhiro, Brifault, Coralie, Lee‐Kubli, Corinne, Regestam, Robert, Henry, Kenneth W., Shiga, Yasuhiro, Kwon, HyoJun, Ohtori, Seiji, Gonias, Steven L., Campana, Wendy M.

“…Sensory neurons in the PNS demonstrate substantial capacity for regeneration following injury. Recent studies have identified changes in the transcriptome of…”
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Ionotropic glutamate receptors activate cell signaling in response to glutamate in Schwann cells by Campana, Wendy M., Mantuano, Elisabetta, Azmoon, Pardis, Henry, Kenneth, Banki, Michael A., Kim, John H., Pizzo, Donald P., Gonias, Steven L.

“…In the peripheral nervous system, Schwann cells (SCs) demonstrate surveillance activity, detecting injury and undergoing trans‐differentiation to support…”
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Peripheral nerve growth within a hydrogel microchannel scaffold supported by a kink‐resistant conduit by Shahriari, Dena, Shibayama, Masataka, Lynam, Daniel A., Wolf, Kayle J., Kubota, Go, Koffler, Jacob Y., Tuszynski, Mark H., Campana, Wendy M., Sakamoto, Jeff S.

“…Nerve repair in several mm‐long nerve gaps often requires an interventional technology. Microchannel scaffolds have proven effective for bridging nerve gaps…”
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PAI1 blocks NMDA receptor-mediated effects of tissue-type plasminogen activator on cell signaling and physiology by Gonias, Steven L, Banki, Michael A, Gilder, Andrew S, Azmoon, Pardis, Campana, Wendy M, Mantuano, Elisabetta

“…The fibrinolysis proteinase tissue-type plasminogen activator (tPA, also known as PLAT) triggers cell signaling and regulates cell physiology. In PC12 cells,…”
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Analysis of the behavioral, cellular and molecular characteristics of pain in severe rodent spinal cord injury by Lee-Kubli, Corinne A., Ingves, Martin, Henry, Kenneth W., Shiao, Rani, Collyer, Eileen, Tuszynski, Mark H., Campana, Wendy M.

“…Human SCI is frequently associated with chronic pain that is severe and refractory to medical therapy. Most rodent models used to assess pain outcomes in SCI…”
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Evidence that LDL receptor-related protein 1 acts as an early injury detection receptor and activates c-Jun in Schwann cells by Flütsch, Andreas, Henry, Kenneth, Mantuano, Elisabetta, Lam, Michael S, Shibayama, Masataka, Takahashi, Kazuhisa, Gonias, Steven L, Campana, Wendy M

“…Schwann cells (SCs) detect injury to peripheral nerves and transform phenotypically to respond to injury and facilitate repair. Cell-signaling pathways and…”
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Tissue-type plasminogen activator-primed human iPSC-derived neural progenitor cells promote motor recovery after severe spinal cord injury by Shiga, Yasuhiro, Shiga, Akina, Mesci, Pinar, Kwon, HyoJun, Brifault, Coralie, Kim, John H., Jeziorski, Jacob J., Nasamran, Chanond, Ohtori, Seiji, Muotri, Alysson R., Gonias, Steven L., Campana, Wendy M.

“…The goal of stem cell therapy for spinal cord injury (SCI) is to restore motor function without exacerbating pain. Induced pluripotent stem cells (iPSC) may be…”
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