Search Results - "Campana, W. Marie"

The NMDA receptor functions independently and as an LRP1 co-receptor to promote Schwann cell survival and migration by Mantuano, Elisabetta, Lam, Michael S, Shibayama, Masataka, Campana, W Marie, Gonias, Steven L

“…NMDA receptors (NMDA-Rs) are ionotropic glutamate receptors, which associate with LDL-receptor-related protein-1 (LRP1) to trigger cell signaling in response…”
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Inflammatory mediators promote production of shed LRP1/CD91, which regulates cell signaling and cytokine expression by macrophages by Gorovoy, Matvey, Gaultier, Alban, Campana, W. Marie, Firestein, Gary S., Gonias, Steven L.

“…The shed form of LRP1/CD91, which is generated at increased levels in inflammation, regulates cell‐signaling and cytokine expression by macrophages. LRP1 is a…”
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The Hemopexin Domain of Matrix Metalloproteinase-9 Activates Cell Signaling and Promotes Migration of Schwann Cells by Binding to Low-Density Lipoprotein Receptor-Related Protein by Mantuano, Elisabetta, Inoue, Gen, Li, Xiaoqing, Takahashi, Kazuhisa, Gaultier, Alban, Gonias, Steven L, Campana, W. Marie

“…Low-density lipoprotein receptor-related protein (LRP-1) is an endocytic receptor for diverse proteins, including matrix metalloproteinase-9 (MMP-9), and a…”
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BDNF gene delivery within and beyond templated agarose multi-channel guidance scaffolds enhances peripheral nerve regeneration by Gao, Mingyong, Lu, Paul, Lynam, Dan, Bednark, Bridget, Campana, W Marie, Sakamoto, Jeff, Tuszynski, Mark

“…We combined implantation of multi-channel templated agarose scaffolds with growth factor gene delivery to examine whether this combinatorial treatment can…”
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Ligand binding to LRP1 transactivates Trk receptors by a Src family kinase-dependent pathway by Shi, Yang, Mantuano, Elisabetta, Inoue, Gen, Campana, W Marie, Gonias, Steven L

“…Low-density lipoprotein receptor-related protein 1 (LRP1) functions in endocytosis and intracellular signaling for a variety of structurally diverse ligands…”
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The unfolded protein response is a major mechanism by which LRP1 regulates Schwann cell survival after injury by Mantuano, Elisabetta, Henry, Kenneth, Yamauchi, Tomonori, Hiramatsu, Nobuhiko, Yamauchi, Kazuyo, Orita, Sumihisa, Takahashi, Kazuhisa, Lin, Jonathan H, Gonias, Steven L, Campana, W Marie

“…In peripheral nerve injury, Schwann cells (SCs) must survive to exert a continuing and essential role in successful nerve regeneration. Herein, we show that…”
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The role of neuroinflammation in neuropathic pain: mechanisms and therapeutic targets by Myers, Robert R., Campana, W. Marie, Shubayev, Veronica I.

“…Cytokine-mediated neuroinflammation controls the pathogenesis of neuropathic pain Neuroinflammation is a proinflammatory cytokine-mediated process that can be…”
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Low-density lipoprotein receptor-related protein 1 is an essential receptor for myelin phagocytosis by Gaultier, Alban, Wu, Xiaohua, Le Moan, Natacha, Takimoto, Shinako, Mukandala, Gatambwa, Akassoglou, Katerina, Campana, W. Marie, Gonias, Steven L

“…Multiple sclerosis (MS) is an autoimmune disease in which myelin is progressively degraded. Because degraded myelin may both initiate and accelerate disease…”
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Exogenous erythropoietin protects against dorsal root ganglion apoptosis and pain following peripheral nerve injury by Campana, W. Marie, Myers, Robert R.

“…Erythropoietin (Epo) has been shown to have potent anti‐apoptotic activity in central nervous system neurons in animal models of ischaemic injury. Recently,…”
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The Low-Density Lipoprotein Receptor-Related Protein Is a Pro-Survival Receptor in Schwann Cells: Possible Implications in Peripheral Nerve Injury by Campana, W. Marie, Li, Xiaoqing, Dragojlovic, Nikola, Janes, Julie, Gaultier, Alban, Gonias, Steven L

“…Schwann cells undergo phenotypic modulation in peripheral nerve injury. In the adult rodent, Schwann cells are resistant to death-promoting challenges. The…”
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The low-density lipoprotein receptor-related protein regulates cancer cell survival and metastasis development by MONTEL, Valerie, GAULTIER, Alban, LESTER, Robin D, CAMPANA, W. Marie, GONIAS, Steven L

“…Low-density lipoprotein receptor-related protein-1 (LRP-1) is a multifunctional receptor involved in receptor-mediated endocytosis and cell signaling. In this…”
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Erythropoietin Promotes MCF-7 Breast Cancer Cell Migration by an ERK/Mitogen-activated Protein Kinase-dependent Pathway and Is Primarily Responsible for the Increase in Migration Observed in Hypoxia by Lester, Robin D., Jo, Minji, Campana, W. Marie, Gonias, Steven L.

“…Recent studies indicate that cancer cells express erythropoietin receptor (EpoR). In this study, we have shown that erythropoietin (Epo) activates the…”
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LDL receptor-related protein-1: a regulator of inflammation in atherosclerosis, cancer, and injury to the nervous system by Gonias, Steven L, Campana, W Marie

“…Low-density lipoprotein receptor-related protein-1 (LRP1) is an endocytic receptor for numerous proteins that are both structurally and functionally diverse…”
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ISSLS prize winner: Erythropoietin inhibits spinal neuronal apoptosis and pain following nerve root crush by SEKIGUCHI, Yasufumi, KIKUCHI, Shinichi, MYERS, Robert R, CAMPANA, W. Marie

“…The authors investigated the association of L5 proximal nerve root injury with spinal cord neuronal apoptosis (histologic) and whether exogenous erythropoietin…”
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TNF-α and phosphorylation of ERK in DRG and spinal cord : Insights into mechanisms of sciatica by TAKAHASHI, Naoto, KIKUCHI, Shinichi, SHUBAYEV, Veronica I, CAMPANA, W. Marie, MYERS, Robert R

“…Characterize extracellular signal-regulated kinase (ERK) and its phosphorylation (pERK) in neural tissues after topical application of tumor necrosis…”
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Low-density Lipoprotein Receptor-related Protein 1 (LRP1)-dependent Cell Signaling Promotes Axonal Regeneration by Yoon, Choya, Van Niekerk, Erna A., Henry, Kenneth, Ishikawa, Tetsuhiro, Orita, Sumihisa, Tuszynski, Mark H., Campana, W. Marie

“…Low-density lipoprotein receptors (LRPs) are present extensively on cells outside of the nervous system and classically exert roles in lipoprotein metabolism…”
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Low Density Lipoprotein Receptor-related Protein (LRP1) Regulates Rac1 and RhoA Reciprocally to Control Schwann Cell Adhesion and Migration by Mantuano, Elisabetta, Jo, Minji, Gonias, Steven L., Campana, W. Marie

“…LDL receptor-related protein (LRP1) is expressed by Schwann cells in vivo mainly after injury to the peripheral nervous system (PNS). Schwann cells in primary…”
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Schwann cell LRP1 regulates remak bundle ultrastructure and axonal interactions to prevent neuropathic pain by Orita, Sumihisa, Henry, Kenneth, Mantuano, Elisabetta, Yamauchi, Kazuyo, De Corato, Alice, Ishikawa, Tetsuhiro, Feltri, M Laura, Wrabetz, Lawrence, Gaultier, Alban, Pollack, Melanie, Ellisman, Mark, Takahashi, Kazuhisa, Gonias, Steven L, Campana, W Marie

“…Trophic support and myelination of axons by Schwann cells in the PNS are essential for normal nerve function. Herein, we show that deletion of the LDL…”
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Cell Death Prevention, Mitogen-Activated Protein Kinase Stimulation, and Increased Sulfatide Concentrations in Schwann Cells and Oligodendrocytes by Prosaposin and Prosaptides by Hiraiwa, Masao, Taylor, Eve M., Campana, W. Marie, Darin, Sam J., O'Brien, John S.

“…Prosaposin, the precursor of saposins A, B, C, and D, was recently identified as a neurotrophic factor. Herein prosaposin was found to increase sulfatide…”
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Regulation of cytokine expression by Schwann cells in response to α2-macroglobulin binding to LRP1 by Shi, Yang, Yamauchi, Tomonori, Gaultier, Alban, Takimoto, Shinako, Campana, W. Marie, Gonias, Steven L.

“…Binding of activated α2‐macroglobulin (α2M) to LDL receptor‐related protein‐1 (LRP1) in Schwann cells activates ERK/MAP kinase and Akt and thereby promotes…”
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