Search Results - "Campain, J A"

Nicotine: Potentially a Multifunctional Carcinogen? by Campain, J A

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Targeted gene delivery to Kaposi's sarcoma cells via the fibroblast growth factor receptor by GOLDMAN, C. K, ROGERS, B. E, DOUGLAS, J. T, SOSNOWSKI, B. A, YING, W, SIEGAL, G. P, BAIRD, A, CAMPAIN, J. A, CURIEL, D. T

“…Kaposi's sarcoma (KS) is a major AIDS-related malignancy associated with significant morbidity and mortality. Current chemotherapeutic regimens are associated…”
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Arsenic and Benzo[a]pyrene Differentially Alter the Capacity for Differentiation and Growth Properties of Primary Human Epidermal Keratinocytes by Perez, D. S., Armstrong-Lea, L., Fox, M. H., Yang, R. S. H., Campain, J. A.

“…Normal human epidermal keratinocytes (NHEK) have been chosen as an in vitro model to test the hypothesis that chemicals which alter or interfere in cellular…”
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Differential DNA methylation of the chorionic gonadotropin beta-subunit multigene family by Campain, J A, Gutkin, D W, Cox, G S

“…In addition to its synthesis in the developing placenta, human CG or the isolated alpha- and beta-subunits are synthesized by a wide variety of both…”
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Toxicological Interactions among Arsenic, Cadmium, Chromium, and Lead in Human Keratinocytes by Bae, Dong-Soon, Gennings, Chris, Carter, Walter H., Yang, Raymond S. H., Campain, Julie A.

“…To evaluate health effects of chemical mixtures, such as multiple heavy metals in drinking water, we have been developing efficient and accurate hazard…”
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Deoxyribonuclease-hypersensitive sites in the glycoprotein hormone alpha-subunit gene from trophoblastic and nontrophoblastic human tumor cell lines: correlation with expression and effect of chemical inducers by Campain, J A, Cox, G S

“…Human CG is composed of two subunits, alpha and beta. In addition to its eutopic synthesis in normal and malignant trophoblasts, the hormone is produced…”
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Characterization of an unusual mutant of human melanoma cells resistant to anticancer drugs that inhibit topoisomerase II by Campain, J A, Padmanabhan, R, Hwang, J, Gottesman, M M, Pastan, I

“…The topoisomerase II inhibitor, VP-16 (etoposide), is an important component in many chemotherapeutic regimens. To characterize resistance to this drug, the…”
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A novel mutant topoisomerase II alpha present in VP-16-resistant human melanoma cell lines has a deletion of alanine 429 by Campain, J A, Gottesman, M M, Pastan, I

“…The human melanoma cell line FEM-X was selected in multiple steps with VP-16 (etoposide) and an inhibitor of P-glycoprotein (Campain et al., 1993). The…”
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Permissive effect of cyclic AMP and cycloheximide for induction by sodium butyrate of the glycoprotein hormone α-subunit gene in choriocarcinoma cells by CAMPAIGN, J. A, EUDY, J. D, COX, G. S

“…Expression of the chorionic gonadotropin alpha-subunit (alpha CG) gene is regulated differently in human tumor cell lines derived from trophoblastic and…”
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Lipid- and adenoviral-mediated gene transfer into AIDS-Kaposi's sarcoma cell lines by Campain, J A, Matassa, A A, Felgner, P L, Barnhart, K M, Curiel, D T, Harrison, G S

“…Kaposi's sarcoma (KS) is the most frequent malignancy occurring in HIV-positive individuals. AIDS-KS is a more aggressive disease than the classical form,…”
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Chorionic gonadotropin synthesis by human tumor cell lines: examination of subunit accumulation, steady-state levels of mRNA, and gene structure by Cosgrove, D E, Campain, J A, Cox, G S

“…A number of tumor cell lines have been examined that differentially produce human chorionic gonadotropin and the isolated alpha- or beta-subunits. It has been…”
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Acquisition of multiple copies of a mutant topoisomerase IIα allele by chromosome 17 aneuploidy is associated with etoposide resistance in human melanoma cell lines by Campain, J. A., Slovak, M. L., Schoenlein, P. V., Popescu, N. C., Gottesman, M. M., Pastan, I.

“…Mutants of the human melanoma cell line, FEM-X, selected in multiple steps with VP-16 (etoposide), are cross resistant to the epipodophyllotoxins and…”
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Characterization of Gene Expression Changes Associated with MNNG, Arsenic, or Metal Mixture Treatment in Human Keratinocytes: Application of cDNA Microarray Technology by Bae, Dong-Soon, Hanneman, William H., Raymond S. H. Yang, Campain, Julie A.

“…The identification of molecular markers related to critical biological processes during carcinogenesis may aid in the evaluation of carcinogenic potentials of…”
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Application of Biologically Based Computer Modeling to Simple or Complex Mixtures by Liao, Kai H., Dobrev, Ivan D., Dennison, James E., Andersen, Melvin E., Reisfeld, Brad, Reardon, Kenneth F., Campain, Julie A., Wei Wei, Klein, Michael T., Quann, Richard J., Raymond S. H. Yang

“…The complexity and the astronomic number of possible chemical mixtures preclude any systematic experimental assessment of toxicology of all potentially…”
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Gene Expression Patterns as Potential Molecular Biomarkers for Malignant Transformation in Human Keratinocytes Treated with MNNG, Arsenic, or a Metal Mixture by Bae, Dong-Soon, Handa, Robert J., Yang, Raymond S. H., Campain, Julie A.

“…In previous studies, treatment with 1-methyl-3-nitro-1-nitrosoguanidine (MNNG) enhanced malignant transformation of immortal human epidermal (RHEK-1)…”
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Chemical mixture toxicology: from descriptive to mechanistic, and going on to in silico toxicology by Yang, Raymond S.H., El-Masri, Hisham A., Thomas, Russell S., Dobrev, Ivan D., Dennison, James E., Bae, Dong-Soon, Campain, Julie A., Liao, Kai H., Reisfeld, Brad, Andersen, Melvin E., Mumtaz, Moiz

“…Because of the pioneering vision of certain leaders in the biomedical field, the last two decades witnessed rapid advances in the area of chemical mixture…”
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BioMOL: A Computer-Assisted Biological Modeling Tool for Complex Chemical Mixtures and Biological Processes at the Molecular Level by Klein, Michael T., Hou, Gang, Quann, Richard J., Wei Wei, Liao, Kai H., Raymond S. H. Yang, Campain, Julie A., Mazurek, Monica A., Broadbelt, Linda J.

“…A chemical engineering approach for the rigorous construction, solution, and optimization of detailed kinetic models for biological processes is described…”
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Arsenic and Benzoapyrene Differentially Alter the Capacity for Differentiation and Growth Properties of Primary Human Epidermal Keratinocytes by Perez, D S, Armstrong-Lea, L, Fox, M H, Yang, RSH, Campain, JA

“…Normal human epidermal keratinocytes (NHEK) have been chosen as an in vitro model to test the hypothesis that chemicals which alter or interfere in cellular…”
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Statistical Analysis of Interactive Cytotoxicity in Human Epidermal Keratinocytes Following Exposure to a Mixture of Four Metals by Gennings, Chris, Carter, Walter H., Campain, Julie A., Bae, Dong-soon, Raymond S. H. Yang

“…Exposure to mixtures of chemicals is an important and relevant environmental issue. Of particular interest is the detection and characterization of departure…”
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Acquisition of multiple copies of a mutant topoisomerase IIalpha allele by chromosome 17 aneuploidy is associated with etoposide resistance in human melanoma cell lines by Campain, J A, Slovak, M L, Schoenlein, P V, Popescu, N C, Gottesman, M M, Pastan, I

“…Mutants of the human melanoma cell line, FEM-X, selected in multiple steps with VP- 16 (etoposide), are cross resistant to the epipodophyllotoxins and…”
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