Search Results - "Campagne, Sébastien"

Structural basis of a small molecule targeting RNA for a specific splicing correction by Campagne, Sébastien, Boigner, Sarah, Rüdisser, Simon, Moursy, Ahmed, Gillioz, Laurent, Knörlein, Anna, Hall, Jonathan, Ratni, Hasane, Cléry, Antoine, Allain, Frédéric H.-T.

“…Splicing modifiers promoting SMN2 exon 7 inclusion have the potential to treat spinal muscular atrophy, the leading genetic cause of infantile death. These…”
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Aberrant interaction of FUS with the U1 snRNA provides a molecular mechanism of FUS induced amyotrophic lateral sclerosis by Jutzi, Daniel, Campagne, Sébastien, Schmidt, Ralf, Reber, Stefan, Mechtersheimer, Jonas, Gypas, Foivos, Schweingruber, Christoph, Colombo, Martino, von Schroetter, Christine, Loughlin, Fionna E., Devoy, Anny, Hedlund, Eva, Zavolan, Mihaela, Allain, Frédéric H.-T., Ruepp, Marc-David

“…Mutations in the RNA-binding protein Fused in Sarcoma (FUS) cause early-onset amyotrophic lateral sclerosis (ALS). However, a detailed understanding of central…”
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Interplay between the catabolite repression control protein Crc, Hfq and RNA in Hfq-dependent translational regulation in Pseudomonas aeruginosa by Sonnleitner, Elisabeth, Wulf, Alexander, Campagne, Sébastien, Pei, Xue-Yuan, Wolfinger, Michael T, Forlani, Giada, Prindl, Konstantin, Abdou, Laetitia, Resch, Armin, Allain, Frederic H -T, Luisi, Ben F, Urlaub, Henning, Bläsi, Udo

“…Abstract In Pseudomonas aeruginosa the RNA chaperone Hfq and the catabolite repression control protein (Crc) act as post-transcriptional regulators during…”
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Binding to SMN2 pre-mRNA-protein complex elicits specificity for small molecule splicing modifiers by Sivaramakrishnan, Manaswini, McCarthy, Kathleen D., Campagne, Sébastien, Huber, Sylwia, Meier, Sonja, Augustin, Angélique, Heckel, Tobias, Meistermann, Hélène, Hug, Melanie N., Birrer, Pascale, Moursy, Ahmed, Khawaja, Sarah, Schmucki, Roland, Berntenis, Nikos, Giroud, Nicolas, Golling, Sabrina, Tzouros, Manuel, Banfai, Balazs, Duran-Pacheco, Gonzalo, Lamerz, Jens, Hsiu Liu, Ying, Luebbers, Thomas, Ratni, Hasane, Ebeling, Martin, Cléry, Antoine, Paushkin, Sergey, Krainer, Adrian R., Allain, Frédéric H.-T., Metzger, Friedrich

“…Small molecule splicing modifiers have been previously described that target the general splicing machinery and thus have low specificity for individual genes…”
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RNA recognition by Npl3p reveals U2 snRNA-binding compatible with a chaperone role during splicing by Moursy, Ahmed, Cléry, Antoine, Gerhardy, Stefan, Betz, Katharina M., Rao, Sanjana, Mazur, Jarosław, Campagne, Sébastien, Beusch, Irene, Duszczyk, Malgorzata M., Robinson, Mark D., Panse, Vikram Govind, Allain, Frédéric H.-T.

“…The conserved SR-like protein Npl3 promotes splicing of diverse pre-mRNAs. However, the RNA sequence(s) recognized by the RNA Recognition Motifs (RRM1 & RRM2)…”
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Exon‐independent recruitment of SRSF1 is mediated by U1 snRNP stem‐loop 3 by Jobbins, Andrew M, Campagne, Sébastien, Weinmeister, Robert, Lucas, Christian M, Gosliga, Alison R, Clery, Antoine, Chen, Li, Eperon, Lucy P, Hodson, Mark J, Hudson, Andrew J, Allain, Frédéric H T, Eperon, Ian C

“…SRSF1 protein and U1 snRNPs are closely connected splicing factors. They both stimulate exon inclusion, SRSF1 by binding to exonic splicing enhancer sequences…”
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Modularity and determinants of a (bi-)polarization control system from free-living and obligate intracellular bacteria by Bergé, Matthieu, Campagne, Sébastien, Mignolet, Johann, Holden, Seamus, Théraulaz, Laurence, Manley, Suliana, Allain, Frédéric H-T, Viollier, Patrick H

“…Although free-living and obligate intracellular bacteria are both polarized it is unclear whether the underlying polarization mechanisms and effector proteins…”
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Structural modeling of protein–RNA complexes using crosslinking of segmentally isotope-labeled RNA and MS/MS by Dorn, Georg, Leitner, Alexander, Boudet, Julien, Campagne, Sébastien, von Schroetter, Christine, Moursy, Ahmed, Aebersold, Ruedi, Allain, Frédéric H-T

“…A mass spectrometry–based method to pinpoint UV-induced crosslinks in ribonucleoprotein complexes at protein residue and RNA nucleotide resolution provides key…”
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SAM68 interaction with U1A modulates U1 snRNP recruitment and regulates mTor pre-mRNA splicing by Subramania, Suryasree, Gagné, Laurence M, Campagne, Sébastien, Fort, Victoire, O’Sullivan, Julia, Mocaer, Karel, Feldmüller, Miki, Masson, Jean-Yves, Allain, Frédéric H T, Hussein, Samer M, Huot, Marc-Étienne

“…Abstract Src associated in mitosis (SAM68) plays major roles in regulating RNA processing events, such as alternative splicing and mRNA translation, implicated…”
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Structure-Function Analysis of the THAP Zinc Finger of THAP1, a Large C2CH DNA-binding Module Linked to Rb/E2F Pathways by Bessière, Damien, Lacroix, Chrystelle, Campagne, Sébastien, Ecochard, Vincent, Guillet, Valérie, Mourey, Lionel, Lopez, Frédéric, Czaplicki, Jerzy, Demange, Pascal, Milon, Alain, Girard, Jean-Philippe, Gervais, Virginie

“…THAP1, the founding member of a previously uncharacterized large family of cellular proteins (THAP proteins), is a sequence-specific DNA-binding factor that…”
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Conformational Heterogeneity of RNA Stem-Loop Hairpins Bound to FUS-RNA Recognition Motif with Disordered RGG Tail Revealed by Unbiased Molecular Dynamics Simulations by Pokorná, Pavlína, Krepl, Miroslav, Campagne, Sébastien, Šponer, Jiří

“…RNA–protein complexes use diverse binding strategies, ranging from structurally well-defined interfaces to completely disordered regions. Experimental…”
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The O-GlcNAc database: introducing new features and tools developed from community feedback by Malard, Florian, Massman, Lilyanna, Campagne, Sébastien, Olivier-Van Stichelen, Stephanie

“…O-GlcNAc is a reversible post-translational modification found on serine and threonine residues of nucleocytoplasmic proteins. Four years ago, we released the…”
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Principles and correction of 5'-splice site selection by Malard, Florian, Mackereth, Cameron D, Campagne, Sébastien

“…In Eukarya, immature mRNA transcripts (pre-mRNA) often contain coding sequences, or exons, interleaved by non-coding sequences, or introns. Introns are removed…”
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Role of Sphingomonas sp. Strain Fr1 PhyR-NepR-σEcfG Cascade in General Stress Response and Identification of a Negative Regulator of PhyR by Kaczmarczyk, Andreas, Campagne, Sébastien, Danza, Francesco, Metzger, Lisa C, Vorholt, Julia A, Francez-Charlot, Anne

“…The general stress response in Alphaproteobacteria was recently described to depend on the alternative sigma factor σEcfG, whose activity is regulated by its…”
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Molecular basis of RNA-binding and autoregulation by the cancer-associated splicing factor RBM39 by Campagne, Sébastien, Jutzi, Daniel, Malard, Florian, Matoga, Maja, Romane, Ksenija, Feldmuller, Miki, Colombo, Martino, Ruepp, Marc-David, Allain, Frédéric H-T.

“…Pharmacologic depletion of RNA-binding motif 39 (RBM39) using aryl sulfonamides represents a promising anti-cancer therapy but requires high levels of the…”
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Structural determinants of specific DNA-recognition by the THAP zinc finger by Campagne, Sébastien, Saurel, Olivier, Gervais, Virginie, Milon, Alain

“…Human THAP1 is the prototype of a large family of cellular factors sharing an original THAP zinc-finger motif responsible for DNA binding. Human THAP1…”
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1H, 13C and 15N backbone resonance assignment of the calcium-activated EndoU endoribonuclease by Malard, Florian, Karginov, Fedor V., Campagne, Sébastien

“…The catalytic domain of the calcium-dependent endoribonuclease EndoU from Homo sapiens was expressed in E. coli with 13 C and 15 N labeling. A nearly complete…”
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Sequence-specific RNA recognition by an RGG motif connects U1 and U2 snRNP for spliceosome assembly by de Vries, Tebbe, Martelly, William, Campagne, Sébastien, Sabath, Kevin, Sarnowski, Chris P, Wong, Jason, Leitner, Alexander, Jonas, Stefanie, Sharma, Shalini, Allain, Frédéric H-T

“…In mammals, the structural basis for the interaction between U1 and U2 small nuclear ribonucleoproteins (snRNPs) during the early steps of splicing is still…”
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An in vitro reconstituted U1 snRNP allows the study of the disordered regions of the particle and the interactions with proteins and ligands by Campagne, Sébastien, de Vries, Tebbe, Malard, Florian, Afanasyev, Pavel, Dorn, Georg, Dedic, Emil, Kohlbrecher, Joachim, Boehringer, Daniel, Cléry, Antoine, Allain, Frédéric H-T

“…Abstract U1 small nuclear ribonucleoparticle (U1 snRNP) plays a central role during RNA processing. Previous structures of U1 snRNP revealed how the…”
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Extra Cytoplasmic Function sigma factors, recent structural insights into promoter recognition and regulation by Campagne, Sébastien, Allain, Frédéric H-T, Vorholt, Julia A

“…•ECF sigma factors are alternative sigma factors involved in gene expression regulation.•During growth, ECF sigma factors are sequestered by specific…”
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