Search Results - "Camins, Antoni"
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Memantine for the Treatment of Dementia: A Review on its Current and Future Applications
Published in Journal of Alzheimer's disease (13-03-2018)“…Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the presence in the brain of extracellular amyloid-β protein (Aβ) and intracellular…”
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Excitotoxicity in the pathogenesis of neurological and psychiatric disorders: Therapeutic implications
Published in Journal of Psychopharmacology (01-03-2018)“…Neurological and psychiatric disorders are leading contributors to the global disease burden, having a serious impact on the quality of life of both patients…”
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3
Memantine loaded PLGA PEGylated nanoparticles for Alzheimer's disease: in vitro and in vivo characterization
Published in Journal of nanobiotechnology (27-03-2018)“…Memantine, drug approved for moderate to severe Alzheimer's disease, has not shown to be fully effective. In order to solve this issue, polylactic-co-glycolic…”
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Metal-based nanoparticles as antimicrobial agents: an overview
Published in Nanomaterials (Basel, Switzerland) (09-02-2020)“…Metal-based nanoparticles have been extensively investigated for a set of biomedical applications. According to the World Health Organization, in addition to…”
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Current Research Therapeutic Strategies for Alzheimer’s Disease Treatment
Published in Neural plasticity (01-01-2016)“…Alzheimer’s disease (AD) currently presents one of the biggest healthcare issues in the developed countries. There is no effective treatment capable of slowing…”
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Current applications of nanoemulsions in cancer therapeutics
Published in Nanomaterials (Basel, Switzerland) (31-05-2019)“…Nanoemulsions are pharmaceutical formulations composed of particles within a nanometer range. They possess the capacity to encapsulate drugs that are poorly…”
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Neuroprotective role of trans-resveratrol in a murine model of familial Alzheimer's disease
Published in Journal of Alzheimer's disease (01-01-2014)“…The amyloid-β protein precursor/presenilin 1 (AβPP/PS1) mouse model of Alzheimer's disease (AD) has provided robust neuropathological hallmarks of familial…”
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ADAM10 in Alzheimer's disease: Pharmacological modulation by natural compounds and its role as a peripheral marker
Published in Biomedicine & pharmacotherapy (01-05-2019)“…[Display omitted] •APP cleavage by the α-secretase ADAM10 releases the soluble portion sAβPPα and prevents the generation of senile plaques.•Non-amyloidogenic…”
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Early alterations in energy metabolism in the hippocampus of APPswe/PS1dE9 mouse model of Alzheimer's disease
Published in Biochimica et biophysica acta (01-09-2014)“…The present study had focused on the behavioral phenotype and gene expression profile of molecules related to insulin receptor signaling in the hippocampus of…”
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Understanding the Role of Hypoxia Inducible Factor During Neurodegeneration for New Therapeutics Opportunities
Published in Current neuropharmacology (2018)“…Neurodegeneration (NDG) is linked with the progressive loss of neural function with intellectual and/or motor impairment. Several diseases affecting older…”
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Protein tyrosine phosphatase 1B (PTP1B) as a potential therapeutic target for neurological disorders
Published in Biomedicine & pharmacotherapy (01-11-2022)“…Protein tyrosine phosphatase 1B (PTP1B) is a typical member of the PTP family, considered a direct negative regulator of several receptor and…”
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Epigallocatechin-3-gallate loaded PEGylated-PLGA nanoparticles: A new anti-seizure strategy for temporal lobe epilepsy
Published in Nanomedicine (01-06-2018)“…Temporal lobe epilepsy is the most common type of pharmacoresistant epilepsy in adults. Epigallocatechin-3-gallate has aroused much interest because of its…”
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Epigallocatechin-3-Gallate (EGCG) Improves Cognitive Deficits Aggravated by an Obesogenic Diet Through Modulation of Unfolded Protein Response in APPswe/PS1dE9 Mice
Published in Molecular neurobiology (01-04-2020)“…Epigallocatechin-3-gallate (EGCG), a catechin found in green tea, has been previously investigated for its neuroprotective effects in vitro and in vivo . In…”
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14
From Inhalation to Neurodegeneration: Air Pollution as a Modifiable Risk Factor for Alzheimer's Disease
Published in International journal of molecular sciences (25-06-2024)“…Air pollution, a growing concern for public health, has been linked to various respiratory and cardiovascular diseases. Emerging evidence also suggests a link…”
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Effects of Nutrition on Cognitive Function in Adults with or without Cognitive Impairment: A Systematic Review of Randomized Controlled Clinical Trials
Published in Nutrients (22-10-2021)“…New dietary approaches for the prevention of cognitive impairment are being investigated. However, evidence from dietary interventions is mainly from food and…”
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The sirtuin pathway in ageing and Alzheimer disease: mechanistic and therapeutic considerations
Published in Lancet neurology (01-03-2011)“…Summary Background Advances in gerontology have yielded crucial insights into the molecular and biochemical aspects of the ageing process. The sirtuin pathway,…”
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High-fat diet-induced deregulation of hippocampal insulin signaling and mitochondrial homeostasis deficiences contribute to Alzheimer disease pathology in rodents
Published in Biochimica et biophysica acta. Molecular basis of disease (01-09-2015)“…Global obesity is a pandemic status, estimated to affect over 2 billion people, that has resulted in an enormous strain on healthcare systems worldwide. The…”
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Metformin a Potential Pharmacological Strategy in Late Onset Alzheimer’s Disease Treatment
Published in Pharmaceuticals (Basel, Switzerland) (01-09-2021)“…Alzheimer’s disease (AD) is one of the most devastating brain disorders. Currently, there are no effective treatments to stop the disease progression and it is…”
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Downregulation of canonical Wnt signaling in hippocampus of SAMP8 mice
Published in Neurobiology of aging (01-02-2015)“…Abstract In the adult brain, canonical Wnt (Wnt/β-catenin) signaling modulates neuronal function, hippocampal neurogenesis, and synaptic plasticity. Indeed,…”
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Metformin restores cognitive dysfunction and histopathological deficits in an animal model of sporadic Alzheimer's disease
Published in Heliyon (01-07-2023)“…Metformin has been introduced as a neuroprotective agent in recent years. Here we evaluate the therapeutic effects of metformin in sporadic mouse model of…”
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