Search Results - "Cameron, Thomas O"
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Anti‐BDCA2 monoclonal antibody inhibits plasmacytoid dendritic cell activation through Fc‐dependent and Fc‐independent mechanisms
Published in EMBO molecular medicine (01-04-2015)“…Type I interferons (IFN‐I) are implicated in the pathogenesis of systemic lupus erythematosus (SLE). In SLE, immune complexes bind to the CD32a (FcγRIIa)…”
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Intravascular immune surveillance by CXCR6+ NKT cells patrolling liver sinusoids
Published in PLoS biology (01-04-2005)“…We examined the in vivo behavior of liver natural killer T cells (NKT cells) by intravital fluorescence microscopic imaging of mice in which a green…”
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3
Identification of Novel Fibrosis Modifiers by In Vivo siRNA Silencing
Published in Molecular therapy. Nucleic acids (16-06-2017)“…Fibrotic diseases contribute to 45% of deaths in the industrialized world, and therefore a better understanding of the pathophysiological mechanisms underlying…”
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Human Immunodeficiency Virus Type 1 Envelope gp120 Induces a Stop Signal and Virological Synapse Formation in Noninfected CD4+ T Cells
Published in Journal of Virology (01-10-2008)“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Structural and kinetic basis for the selectivity of aducanumab for aggregated forms of amyloid-β
Published in Scientific reports (23-04-2018)“…Aducanumab, a human-derived antibody targeting amyloid-β (Aβ), is in Phase 3 clinical trials for the treatment of Alzheimer’s disease. Biochemical and…”
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6
MOG autoantibodies trigger a tightly-controlled FcR and BTK-driven microglia proliferative response
Published in Brain (London, England : 1878) (04-09-2021)“…Autoantibodies are a hallmark of numerous neurological disorders, including multiple sclerosis, autoimmune encephalitides and neuromyelitis optica. Whilst well…”
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Radiation-Induced CXCL16 Release by Breast Cancer Cells Attracts Effector T Cells
Published in The Journal of immunology (1950) (01-09-2008)“…Recruitment of effector T cells to inflamed peripheral tissues is regulated by chemokines and their receptors, but the factors regulating recruitment to tumors…”
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Lrp4 Is a Receptor for Agrin and Forms a Complex with MuSK
Published in Cell (17-10-2008)“…Neuromuscular synapse formation requires a complex exchange of signals between motor neurons and skeletal muscle fibers, leading to the accumulation of…”
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Preclinical Analysis of Candidate Anti-Human CD79 Therapeutic Antibodies Using a Humanized CD79 Mouse Model
Published in The Journal of immunology (1950) (01-04-2022)“…The BCR comprises a membrane-bound Ig that is noncovalently associated with a heterodimer of CD79A and CD79B. While the BCR Ig component functions to sense…”
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Major Histocompatibility Complex and T Cell Interactions of a Universal T Cell Epitope from Plasmodium falciparum Circumsporozoite Protein
Published in The Journal of biological chemistry (26-05-2006)“…A 20-residue sequence from the C-terminal region of the circumsporozoite protein of the malaria parasite Plasmodium falciparum is considered a universal helper…”
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Peptide-MHC potency governs dynamic interactions between T cells and dendritic cells in lymph nodes
Published in Nature Immunology (01-08-2007)“…T cells survey antigen-presenting dendritic cells (DCs) by migrating through DC networks, arresting and maintaining contact with DCs for several hours after…”
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Kinetics of Early T Cell Receptor Signaling Regulate the Pathway of Lytic Granule Delivery to the Secretory Domain
Published in Immunity (Cambridge, Mass.) (16-10-2009)“…Cytolytic granules mediate killing of virus-infected cells by cytotoxic T lymphocytes. We show here that the granules can take long or short paths to the…”
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Cutting Edge: Activation by Innate Cytokines or Microbial Antigens Can Cause Arrest of Natural Killer T Cell Patrolling of Liver Sinusoids
Published in The Journal of immunology (1950) (15-02-2008)“…Natural killer T (NKT) cells are innate-like lymphocytes that rapidly secrete large amounts of effector cytokines upon activation. Recognition of alpha-linked…”
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Interference with Ca(2+) release activated Ca(2+) (CRAC) channel function delays T-cell arrest in vivo
Published in European journal of immunology (01-12-2013)“…Entry of lymphocytes into secondary lymphoid organs (SLOs) involves intravascular arrest and intracellular calcium ion ([Ca(2+)]i) elevation. TCR activation…”
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Interference with Ca2+ release activated Ca2+ (CRAC) channel function delays T‐cell arrest in vivo
Published in European journal of immunology (01-12-2013)“…Entry of lymphocytes into secondary lymphoid organs (SLOs) involves intravascular arrest and intracellular calcium ion ([Ca2+]i) elevation. TCR activation…”
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Protein kinase C theta regulates stability of the peripheral adhesion ring junction and contributes to the sensitivity of target cell lysis by CTL
Published in The Journal of immunology (1950) (01-10-2008)“…Destruction of virus-infected cells by CTL is an extremely sensitive and efficient process. Our previous data suggest that LFA-1-ICAM-1 interactions in the…”
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The Relationship of MHC-Peptide Binding and T Cell Activation Probed Using Chemically Defined MHC Class II Oligomers
Published in Immunity (Cambridge, Mass.) (01-03-2000)“…A series of novel chemically defined soluble oligomers of the human MHC class II protein HLA-DR1 was constructed to probe the molecular requirements for…”
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The Duration of Exposure to HIV Modulates the Breadth and the Magnitude of HIV-Specific Memory CD4+ T Cells
Published in The Journal of immunology (1950) (15-01-2007)“…The impact of exposure to Ag on the development and maintenance of human CD4(+) memory T cells in general and HIV infection in particular is partially…”
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Receptor clustering and transmembrane signaling in T cells
Published in Trends in Biochemical Sciences (01-05-2001)“…T cells are activated via engagement of their cell-surface receptors with molecules of the major histocompatibility complex (MHC) displayed on another cell…”
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Cutting Edge: TCR Engagement and Triggering in the Absence of Large-Scale Molecular Segregation at the T Cell-APC Contact Site
Published in The Journal of immunology (1950) (01-05-2002)“…We investigated the functional role of large-scale molecular segregation at the T cell-APC contact site during T lymphocyte Ag recognition. Inhibition of…”
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