Search Results - "Cameron, Kenneth S."

NMR Diffusion Spectroscopy as a Measure of Host−Guest Complex Association Constants and as a Probe of Complex Size by Cameron, Kenneth S, Fielding, Lee

“…The complexes of cyclohexylacetic acid and cholic acid with β-cyclodextrin were studied by NMR diffusion coefficient measurements. The diffusion coefficient of…”
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4-(3-Trifluoromethylphenyl)-pyrimidine-2-carbonitrile as cathepsin S inhibitors: N3, not N1 is critically important by Cai, Jiaqiang, Fradera, Xavier, van Zeeland, Mario, Dempster, Maureen, Cameron, Kenneth S., Bennett, D. Jonathan, Robinson, John, Popplestone, Lucy, Baugh, Mark, Westwood, Paul, Bruin, John, Hamilton, William, Kinghorn, Emma, Long, Clive, Uitdehaag, Joost C.M.

“…The N3 nitrogen of the pyrimidine-2-carbonitrile based cathepsin cysteine protease inhibitors is critically important. An ‘in situ double activation’ mechanism…”
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1H-Imidazo[4,5-c]pyridine-4-carbonitrile as cathepsin S inhibitors: Separation of desired cellular activity from undesired tissue accumulation through optimization of basic nitrogen pkₐ by Arbuckle, Wullie, Baugh, Mark, Belshaw, Simone, Bennett, D. Jonathan, Bruin, John, Cai, Jiaqiang, Cameron, Kenneth S, Claxton, Chris, Dempster, Maureen, Everett, Kathryn, Fradera, Xavier, Hamilton, William, Jones, Philip S, Kinghorn, Emma, Long, Clive, Martin, Iain, Robinson, John, Westwood, Paul

“…Based on the theoretical understanding of the in vivo lysosomotropism, by adjusting the pkₐ of basic nitrogen containing cathepsin S inhibitors, a set of…”
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6-Phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile as cathepsin S inhibitors by Cai, Jiaqiang, Baugh, Mark, Black, Darcey, Long, Clive, Jonathan Bennett, D., Dempster, Maureen, Fradera, Xavier, Gillespie, Jonathan, Andrews, Fiona, Boucharens, Sylviane, Bruin, John, Cameron, Kenneth S., Cumming, Iain, Hamilton, William, Jones, Philip S., Kaptein, Allard, Kinghorn, Emma, Maidment, Maurice, Martin, Iain, Mitchell, Ann, Rankovic, Zoran, Robinson, John, Scullion, Paul, Uitdehaag, Joost C.M., Vink, Paul, Westwood, Paul, van Zeeland, Mario, van Berkom, Leon, Bastiani, Martijn, Meulemans, Tommi

“…6-Phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile derivatives were identified as selective human cathepsin S inhibitors with a stable thiol trapping nitrile…”
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2-Phenyl-9H-purine-6-carbonitrile derivatives as selective cathepsin S inhibitors by Cai, Jiaqiang, Bennett, D. Jonathan, Rankovic, Zoran, Dempster, Maureen, Fradera, Xavier, Gillespie, Jonathan, Cumming, Iain, Finlay, William, Baugh, Mark, Boucharens, Sylviane, Bruin, John, Cameron, Kenneth S., Hamilton, William, Kerr, Jennifer, Kinghorn, Emma, McGarry, George, Robinson, John, Scullion, Paul, Uitdehaag, Joost C.M., van Zeeland, Mario, Potin, Dominique, Saniere, Laurent, Fouquet, Andre, Chevallier, Francois, Deronzier, Hortense, Dorleans, Cecile, Nicolai, Eric

“…2-Phenyl-9H-purine-6-carbonitrile derivatives were designed as selective human cathepsin S inhibitors through P2 optimization and transition state…”
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Anionic Cyclophanes as Potential Reversal Agents of Muscle Relaxants by Chemical Chelation by Cameron, Kenneth S., Fielding, Lee, Mason, Rona, Muir, Alan W., Rees, David C., Thorn, Simon, Zhang, Ming-Qiang

“…A series of carboxyl-containing cyclophanes have been designed and synthesised as chemical chelators (or host molecules) of cationic muscle relaxant drugs (or…”
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Five-Membered Ring Rotations, Pseudorotations, and Hydrogen Bond Exchange Dynamics in the Solid State Studied by NMR Spectroscopy by Riddell, Frank G, Cameron, Kenneth S, Holmes, Susan A, Strange, John H

“…13C CP/MAS NMR studies were carried out on trans-1,2-cyclopentanediol, on 4,4-dimethyl-trans-1,2-cyclopentanediol, and on sulfolane at variable temperatures…”
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NMR diffusion coefficient study of steroid-cyclodextrin inclusion complexes by Cameron, Kenneth S., Fielding, Lee

“…The complexes formed by the steroid rocuronium bromide with four different cyclodextrins (β‐cyclodextrin, γ‐cyclodextrin, Org 26054 and Org 25969) were…”
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1H-Imidazo[4,5-c]pyridine-4-carbonitrile as cathepsin S inhibitors: Separation of desired cellular activity from undesired tissue accumulation through optimization of basic nitrogen pk sub(a) by Arbuckle, Wullie, Baugh, Mark, Belshaw, Simone, Bennett, DJonathan, Bruin, John, Cai, Jiaqiang, Cameron, Kenneth S, Claxton, Chris, Dempster, Maureen, Everett, Kathryn, Fradera, Xavier, Hamilton, William, Jones, Philip S, Kinghorn, Emma, Long, Clive, Martin, Iain, Robinson, John, Westwood, Paul

“…Based on the theoretical understanding of the in vivo lysosomotropism, by adjusting the pk sub(a) of basic nitrogen containing cathepsin S inhibitors, a set of…”
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1 H-Imidazo[4,5- c]pyridine-4-carbonitrile as cathepsin S inhibitors: Separation of desired cellular activity from undesired tissue accumulation through optimization of basic nitrogen p k a by Arbuckle, Wullie, Baugh, Mark, Belshaw, Simone, Bennett, D. Jonathan, Bruin, John, Cai, Jiaqiang, Cameron, Kenneth S., Claxton, Chris, Dempster, Maureen, Everett, Kathryn, Fradera, Xavier, Hamilton, William, Jones, Philip S., Kinghorn, Emma, Long, Clive, Martin, Iain, Robinson, John, Westwood, Paul

“…Based on the theoretical understanding of the in vivo lysosomotropism, by manipulating the p k a of the cathepsin S inhibitors, a set of compounds with p k a…”
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Optimization of Reaction Conditions for REM Resin-Bound Quaternization Reactions by Cameron, Kenneth S, Morphy, J. Richard, Rankovic, Zoran, York, Mark

“…A study into the effect of reaction variables on the quaternization of REM resin-bound tertiary amines was undertaken. The influence of resin matrix, solvent,…”
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An NMR study of cyclodextrin complexes of the steroidal neuromuscular blocker drug Rocuronium Bromide by Cameron, Kenneth S., Fletcher, Dan, Fielding, Lee

“…The interaction of Rocuronium Bromide, and a model steroid Org 7402, with three cyclodextrins (β‐cyclodextrin, γ‐cyclodextrin and Org 25969) was studied by…”
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