Search Results - "Cameron, Angus"

PKC and the control of localized signal dynamics by Parker, Peter J, Rosse, Carine, Linch, Mark, Kermorgant, Stéphanie, Cameron, Angus J. M, Boeckeler, Katrina

“…Key Points The protein kinase C (PKC) family of lipid-activated protein kinases lend themselves to compartmentalized action, a property of signalling systems…”
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WIST guidelines: a global solution to increase interventional stroke treatment by Cameron, Angus

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Cancer‐associated fibroblasts in pancreatic cancer: new subtypes, new markers, new targets by Menezes, Shinelle, Okail, Mohamed Hazem, Jalil, Siti Munira Abd, Kocher, Hemant M, Cameron, Angus J M

“…Cancer‐associated fibroblasts (CAFs) have conflicting roles in the suppression and promotion of cancer. Current research focuses on targeting the undesirable…”
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The Future of Precision Oncology by Rulten, Stuart L, Grose, Richard P, Gatz, Susanne A, Jones, J. Louise, Cameron, Angus J. M

“…Our understanding of the molecular mechanisms underlying cancer development and evolution have evolved rapidly over recent years, and the variation from one…”
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Protein kinase N1 critically regulates cerebellar development and long-term function by zur Nedden, Stephanie, Eith, Rafaela, Schwarzer, Christoph, Zanetti, Lucia, Seitter, Hartwig, Fresser, Friedrich, Koschak, Alexandra, Cameron, Angus Jm, Parker, Peter J, Baier, Gottfried, Baier-Bitterlich, Gabriele

“…Increasing evidence suggests that synapse dysfunctions are a major determinant of several neurodevelopmental and neurodegenerative diseases. Here we identify…”
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Disruption of pancreatic stellate cell myofibroblast phenotype promotes pancreatic tumor invasion by Murray, Elizabeth R., Menezes, Shinelle, Henry, Jack C., Williams, Josie L., Alba-Castellón, Lorena, Baskaran, Priththivika, Quétier, Ivan, Desai, Ami, Marshall, Jacqueline J.T., Rosewell, Ian, Tatari, Marianthi, Rajeeve, Vinothini, Khan, Faraz, Wang, Jun, Kotantaki, Panoraia, Tyler, Eleanor J., Singh, Namrata, Reader, Claire S., Carter, Edward P., Hodivala-Dilke, Kairbaan, Grose, Richard P., Kocher, Hemant M., Gavara, Nuria, Pearce, Oliver, Cutillas, Pedro, Marshall, John F., Cameron, Angus J.M.

“…In pancreatic ductal adenocarcinoma (PDAC), differentiation of pancreatic stellate cells (PSCs) into myofibroblast-like cancer-associated fibroblasts (CAFs)…”
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Knockout of the PKN Family of Rho Effector Kinases Reveals a Non-redundant Role for PKN2 in Developmental Mesoderm Expansion by Quétier, Ivan, Marshall, Jacqueline J.T., Spencer-Dene, Bradley, Lachmann, Sylvie, Casamassima, Adele, Franco, Claudio, Escuin, Sarah, Worrall, Joseph T., Baskaran, Priththivika, Rajeeve, Vinothini, Howell, Michael, Copp, Andrew J., Stamp, Gordon, Rosewell, Ian, Cutillas, Pedro, Gerhardt, Holger, Parker, Peter J., Cameron, Angus J.M.

“…In animals, the protein kinase C (PKC) family has expanded into diversely regulated subgroups, including the Rho family-responsive PKN kinases. Here, we…”
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Genomic Subtypes of Non-invasive Bladder Cancer with Distinct Metabolic Profile and Female Gender Bias in KDM6A Mutation Frequency by Hurst, Carolyn D., Alder, Olivia, Platt, Fiona M., Droop, Alastair, Stead, Lucy F., Burns, Julie E., Burghel, George J., Jain, Sunjay, Klimczak, Leszek J., Lindsay, Helen, Roulson, Jo-An, Taylor, Claire F., Thygesen, Helene, Cameron, Angus J., Ridley, Anne J., Mott, Helen R., Gordenin, Dmitry A., Knowles, Margaret A.

“…Bladder cancer incurs a higher lifetime treatment cost than other cancers due to frequent recurrence of non-invasive disease. Improved prognostic biomarkers…”
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PKC maturation is promoted by nucleotide pocket occupation independently of intrinsic kinase activity by Parker, Peter J, Cameron, Angus J M, Escribano, Cristina, Saurin, Adrian T, Kostelecky, Brenda

“…Protein kinase C epsilon (PKCε) priming involves phosphorylation of the kinase domain at 3 different sites. Whether these phosphorylation events were…”
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Towards specific inhibition of mTORC2 by Murray, Elizabeth R, Cameron, Angus J M

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Protein Kinase C-β Dictates B Cell Fate by Regulating Mitochondrial Remodeling, Metabolic Reprogramming, and Heme Biosynthesis by Tsui, Carlson, Martinez-Martin, Nuria, Gaya, Mauro, Maldonado, Paula, Llorian, Miriam, Legrave, Nathalie M., Rossi, Merja, MacRae, James I., Cameron, Angus J., Parker, Peter J., Leitges, Michael, Bruckbauer, Andreas, Batista, Facundo D.

“…PKCβ-null (Prkcb−/−) mice are severely immunodeficient. Here we show that mice whose B cells lack PKCβ failed to form germinal centers and plasma cells, which…”
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Strategies for the Global Eradication of Peste des Petits Ruminants: An Argument for the Use of Guerrilla Rather Than Trench Warfare by Cameron, Angus R.

“…Many historical disease eradication campaigns have been characterized by large-scale mobilization and long-term campaigns of mass vaccination. As the duration…”
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INVESTIGATING BLOOD LACTATE CONCENTRATION AS A PROGNOSTIC INDICATOR FOR BIRDS PRESENTING WITH BREVETOXICOSIS: 2020-2021 by Troiano, Alexandra T, Peel, Melanie, Cameron, Angus I, Bast, Robin, Flewelling, Leanne, Abbott, Jay, Barron, Heather

“…Large blooms of the dinoflagellate cause annual harmful algal bloom events, or "red tides" on Florida's Gulf Coast. Each year, the Clinic for the…”
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Targets in the Tumour Matrisome to Promote Cancer Therapy Response by Jalil, Siti Munira Abd, Henry, Jack C, Cameron, Angus J M

“…The extracellular matrix (ECM) is composed of complex fibrillar proteins, proteoglycans, and macromolecules, generated by stromal, immune, and cancer cells…”
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mTORC2 targets AGC kinases through Sin1-dependent recruitment by Cameron, Angus J M, Linch, Mark D, Saurin, Adrian T, Escribano, Cristina, Parker, Peter J

“…The protein kinase TOR (target of rapamycin) is a key regulator of cell growth and metabolism with significant clinical relevance. In mammals, TOR signals…”
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Meta-analyses of the sensitivity and specificity of ante-mortem and post-mortem diagnostic tests for bovine tuberculosis in the UK and Ireland by Nuñez-Garcia, Javier, Downs, Sara H., Parry, Jessica E., Abernethy, Darrell A., Broughan, Jennifer M., Cameron, Angus R., Cook, Alasdair J., de la Rua-Domenech, Ricardo, Goodchild, Anthony V., Gunn, Jane, More, Simon J., Rhodes, Shelley, Rolfe, Simon, Sharp, Michael, Upton, Paul A., Vordermeier, H. Martin, Watson, Eamon, Welsh, Michael, Whelan, Adam O., Woolliams, John A., Clifton-Hadley, Richard S., Greiner, Matthias

“…•First comparison of different bovine tuberculosis tests estimated by meta-analyses.•Sensitivity estimate of single comparative cervical tuberculin test…”
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Needs and capabilities for improving poultry production and health management in Indonesia by Chapot, Lorraine, Hibbard, Rebecca, Ariyanto, Kurnia Bagus, Maulana, Kusnul Yuli, Yusuf, Havan, Febriyani, Widya, Cameron, Angus, Paul, Mathilde, Vergne, Timothée, Faverjon, Céline

“…In Indonesia, the development of the poultry industry is facing numerous challenges. Major constraints include high disease burdens, large fluctuations in farm…”
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Cascading ecological effects of eliminating fishery discards by Heath, Michael R., Cook, Robin M., Cameron, Angus I., Morris, David J., Speirs, Douglas C.

“…Discarding by fisheries is perceived as contrary to responsible harvesting. Legislation seeking to end the practice is being introduced in many jurisdictions…”
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Opposing roles for ADAMTS2 and ADAMTS14 in myofibroblast differentiation and function by Carter, Edward P, Yoneten, Kubra K, Gavara, Nuria, Tyler, Eleanor J, Gauthier, Valentine, Murray, Elizabeth R, Dijke, Peter, Cameron, Angus J, Pearce, Oliver, Grose, Richard P

“…Crosstalk between cancer and stellate cells is pivotal in pancreatic cancer, resulting in differentiation of stellate cells into myofibroblasts that drives…”
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“It’s a habit. They’ve been doing it for decades and they feel good and safe.”: A qualitative study of barriers and opportunities to changing antimicrobial use in the Indonesian poultry sector by Hibbard, Rebecca, Chapot, Lorraine, Yusuf, Havan, Ariyanto, Kurnia Bagus, Maulana, Kusnul Yuli, Febriyani, Widya, Cameron, Angus, Vergne, Timothée, Faverjon, Céline, Paul, Mathilde C

“…Interventions to change antimicrobial use (AMU) practices can help mitigate the risk of antimicrobial resistance (AMR) development. However, changing AMU…”
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