Search Results - "Cameron, Alexander D"

Crystal structure of a bacterial homologue of the bile acid sodium symporter ASBT by Hu, Nien-Jen, Iwata, So, Cameron, Alexander D., Drew, David

“…Structure of a bile acid transporter Elevated cholesterol levels significantly increase the risk of atherosclerosis and cardiovascular diseases. Cholesterol is…”
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Crystal structure of the anion exchanger domain of human erythrocyte band 3 by Arakawa, Takatoshi, Kobayashi-Yurugi, Takami, Alguel, Yilmaz, Iwanari, Hiroko, Hatae, Hinako, Iwata, Momi, Abe, Yoshito, Hino, Tomoya, Ikeda-Suno, Chiyo, Kuma, Hiroyuki, Kang, Dongchon, Murata, Takeshi, Hamakubo, Takao, Cameron, Alexander D., Kobayashi, Takuya, Hamasaki, Naotaka, Iwata, So

“…Anion exchanger 1 (AE1), also known as band 3 or SLC4A1, plays a key role in the removal of carbon dioxide from tissues by facilitating the exchange of…”
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Overcoming the challenges of membrane protein crystallography by Carpenter, Elisabeth P, Beis, Konstantinos, Cameron, Alexander D, Iwata, So

“…Membrane protein structural biology is still a largely unconquered area, given that approximately 25% of all proteins are membrane proteins and yet less than…”
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Alternating access mechanism in the POT family of oligopeptide transporters by Solcan, Nicolae, Kwok, Jane, Fowler, Philip W, Cameron, Alexander D, Drew, David, Iwata, So, Newstead, Simon

“…Short chain peptides are actively transported across membranes as an efficient route for dietary protein absorption and for maintaining cellular homeostasis…”
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A two-domain elevator mechanism for sodium/proton antiport by Lee, Chiara, Kang, Hae Joo, von Ballmoos, Christoph, Newstead, Simon, Uzdavinys, Povilas, Dotson, David L., Iwata, So, Beckstein, Oliver, Cameron, Alexander D., Drew, David

“…The X-ray crystal structure of NapA, a Na + /H + antiporter from Thermus thermophilus , in an active, outward-facing state is reported; comparisons to the…”
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Structure of eukaryotic purine/H+ symporter UapA suggests a role for homodimerization in transport activity by Alguel, Yilmaz, Amillis, Sotiris, Leung, James, Lambrinidis, George, Capaldi, Stefano, Scull, Nicola J., Craven, Gregory, Iwata, So, Armstrong, Alan, Mikros, Emmanuel, Diallinas, George, Cameron, Alexander D., Byrne, Bernadette

“…The uric acid/xanthine H + symporter, UapA, is a high-affinity purine transporter from the filamentous fungus Aspergillus nidulans . Here we present the…”
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G-protein-coupled receptor inactivation by an allosteric inverse-agonist antibody by Hino, Tomoya, Arakawa, Takatoshi, Iwanari, Hiroko, Yurugi-Kobayashi, Takami, Ikeda-Suno, Chiyo, Nakada-Nakura, Yoshiko, Kusano-Arai, Osamu, Weyand, Simone, Shimamura, Tatsuro, Nomura, Norimichi, Cameron, Alexander D., Kobayashi, Takuya, Hamakubo, Takao, Iwata, So, Murata, Takeshi

“…Determination of the crystal structure of the human A 2A adenosine receptor in complex with an inverse-agonist antibody shows that the allosteric site of the…”
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Transporter oligomerization: form and function by Alguel, Yilmaz, Cameron, Alexander D, Diallinas, George, Byrne, Bernadette

“…Transporters are integral membrane proteins with central roles in the efficient movement of molecules across biological membranes. Many transporters exist as…”
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Cryo-EM of multiple cage architectures reveals a universal mode of clathrin self-assembly by Morris, Kyle L., Jones, Joseph R., Halebian, Mary, Wu, Shenping, Baker, Michael, Armache, Jean-Paul, Avila Ibarra, Amaurys, Sessions, Richard B., Cameron, Alexander D., Cheng, Yifan, Smith, Corinne J.

“…Clathrin forms diverse lattice and cage structures that change size and shape rapidly in response to the needs of eukaryotic cells during clathrin-mediated…”
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Light‐Activated Electron Transfer and Catalytic Mechanism of Carnitine Oxidation by Rieske‐Type Oxygenase from Human Microbiota by Shanmugam, Muralidharan, Quareshy, Mussa, Cameron, Alexander D., Bugg, Timothy D. H., Chen, Yin

“…Oxidation of quaternary ammonium substrate, carnitine by non‐heme iron containing Acinetobacter baumannii (Ab) oxygenase CntA/reductase CntB is implicated in…”
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Mechanism of substrate binding and transport in BASS transporters by Becker, Patrick, Naughton, Fiona, Brotherton, Deborah, Pacheco-Gomez, Raul, Beckstein, Oliver, Cameron, Alexander D

“…The bile acid sodium symporter (BASS) family transports a wide array of molecules across membranes, including bile acids in humans, and small metabolites in…”
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Crystal structure of a prokaryotic homologue of the mammalian oligopeptide-proton symporters, PepT1 and PepT2 by Newstead, Simon, Drew, David, Cameron, Alexander D, Postis, Vincent L G, Xia, Xiaobing, Fowler, Philip W, Ingram, Jean C, Carpenter, Elisabeth P, Sansom, Mark S P, McPherson, Michael J, Baldwin, Stephen A, Iwata, So

“…PepT1 and PepT2 are major facilitator superfamily (MFS) transporters that utilize a proton gradient to drive the uptake of di‐ and tri‐peptides in the small…”
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structure of the yeast NADH dehydrogenase (Ndi1) reveals overlapping binding sites for water- and lipid-soluble substrates by Iwata, Momi, Lee, Yang, Yamashita, Tetsuo, Yagi, Takao, Iwata, So, Cameron, Alexander D, Maher, Megan J

“…Bioenergy is efficiently produced in the mitochondria by the respiratory system consisting of complexes I–V. In various organisms, complex I can be replaced by…”
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Molecular Basis of Alternating Access Membrane Transport by the Sodium-Hydantoin Transporter Mhp1 by Shimamura, Tatsuro, Weyand, Simone, Beckstein, Oliver, Rutherford, Nicholas G, Hadden, Jonathan M, Sharples, David, Sansom, Mark S.P, Iwata, So, Henderson, Peter J.F, Cameron, Alexander D

“…The structure of the sodium-benzylhydantoin transport protein Mhp1 from Microbacterium liquefaciens comprises a five-helix inverted repeat, which is widespread…”
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Crystal structure of the sodium-proton antiporter NhaA dimer and new mechanistic insights by Lee, Chiara, Yashiro, Shoko, Dotson, David L, Uzdavinys, Povilas, Iwata, So, Sansom, Mark S P, von Ballmoos, Christoph, Beckstein, Oliver, Drew, David, Cameron, Alexander D

“…Sodium-proton antiporters rapidly exchange protons and sodium ions across the membrane to regulate intracellular pH, cell volume, and sodium concentration. How…”
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Crystal Structure of Glucansucrase from the Dental Caries Pathogen Streptococcus mutans by Ito, Keisuke, Ito, Sohei, Shimamura, Tatsuro, Weyand, Simone, Kawarasaki, Yasuaki, Misaka, Takumi, Abe, Keiko, Kobayashi, Takuya, Cameron, Alexander D., Iwata, So

“…Glucansucrase (GSase) from Streptococcus mutans is an essential agent in dental caries pathogenesis. Here, we report the crystal structure of S. mutans…”
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Structural and functional insights into the mechanism of action of plant borate transporters by Saouros, Savvas, Mohan, Thotegowdanapalya C., Cecchetti, Cristina, Lehmann, Silke, Barrit, Joseph D., Scull, Nicola J., Simpson, Paul, Alguel, Yilmaz, Cameron, Alexander D., Jones, Alexandra M. E., Byrne, Bernadette

“…Boron has essential roles in plant growth and development. BOR proteins are key in the active uptake and distribution of boron, and regulation of intracellular…”
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Molecular mechanism of ligand recognition by membrane transport protein, Mhp1 by Simmons, Katie J, Jackson, Scott M, Brueckner, Florian, Patching, Simon G, Beckstein, Oliver, Ivanova, Ekaterina, Geng, Tian, Weyand, Simone, Drew, David, Lanigan, Joseph, Sharples, David J, Sansom, Mark SP, Iwata, So, Fishwick, Colin WG, Johnson, A Peter, Cameron, Alexander D, Henderson, Peter JF

“…The hydantoin transporter Mhp1 is a sodium‐coupled secondary active transport protein of the nucleobase‐cation‐symport family and a member of the widespread…”
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Transfer of stabilising mutations between different secondary active transporter families by Cecchetti, Cristina, Scull, Nicola J., Mohan, Thotegowdanapalya C., Alguel, Yilmaz, Jones, Alexandra M. C., Cameron, Alexander D., Byrne, Bernadette

“…Integral membrane transporters play essential roles in the movement of substrates across biological membranes. One approach to produce transporters suitable…”
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Structure and mechanism of the chalcogen-detoxifying protein TehB from Escherichia coli by Choudhury, Hassanul G, Cameron, Alexander D, Iwata, So, Beis, Konstantinos

“…The oxyanion derivatives of the chalcogens tellurium and selenium are toxic to living organisms even at very low levels. Bacteria have developed mechanisms to…”
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