Search Results - "Cambria, Clara"
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Loss of CDKL5 Causes Synaptic GABAergic Defects That Can Be Restored with the Neuroactive Steroid Pregnenolone-Methyl-Ether
Published in International journal of molecular sciences (21-12-2022)“…CDKL5 deficiency disorder (CDD) is an X-linked neurodevelopmental disorder characterised by early-onset drug-resistant epilepsy and impaired cognitive and…”
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ATM rules neurodevelopment and glutamatergic transmission in the hippocampus but not in the cortex
Published in Cell death & disease (16-07-2022)“…Interest in the function of ataxia-telangiectasia-mutated protein (ATM) is extensively growing as evidenced by preclinical studies that continuously link ATM…”
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New Views of the DNA Repair Protein Ataxia–Telangiectasia Mutated in Central Neurons: Contribution in Synaptic Dysfunctions of Neurodevelopmental and Neurodegenerative Diseases
Published in Cells (Basel, Switzerland) (30-08-2023)“…Ataxia–Telangiectasia Mutated (ATM) is a serine/threonine protein kinase principally known to orchestrate DNA repair processes upon DNA double-strand breaks…”
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Synovial Fluid-Derived Extracellular Vesicles of Patients with Arthritides Contribute to Hippocampal Synaptic Dysfunctions and Increase with Mood Disorders Severity in Humans
Published in Cells (Basel, Switzerland) (23-07-2022)“…Arthritides are a highly heterogeneous group of disorders that include two major clinical entities, localized joint disorders such as osteoarthritis (OA) and…”
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The DNA repair protein ATM as a target in autism spectrum disorder
Published in JCI insight (08-02-2021)“…Impairment of the GABAergic system has been reported in epilepsy, autism, attention deficit hyperactivity disorder, and schizophrenia. We recently demonstrated…”
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Glucose-derived glutamate drives neuronal terminal differentiation in vitro
Published in EMBO reports (12-03-2024)“…Neuronal maturation is the phase during which neurons acquire their final characteristics in terms of morphology, electrical activity, and metabolism. However,…”
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Neural precursor cells rescue symptoms of Rett syndrome by activation of the Interferon γ pathway
Published in EMBO molecular medicine (20-09-2024)“…The beneficial effects of Neural Precursor Cell (NPC) transplantation in several neurological disorders are well established and they are generally mediated by…”
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