Search Results - "Cambier, C.J."

Host Evasion and Exploitation Schemes of Mycobacterium tuberculosis by Cambier, C.J., Falkow, Stanley, Ramakrishnan, Lalita

“…Tuberculosis, an ancient disease of mankind, remains one of the major infectious causes of human death. We examine newly discovered facets of tuberculosis…”
Get full text

Phenolic Glycolipid Facilitates Mycobacterial Escape from Microbicidal Tissue-Resident Macrophages by Cambier, C.J., O’Leary, Seónadh M., O’Sullivan, Mary P., Keane, Joseph, Ramakrishnan, Lalita

“…Mycobacterium tuberculosis (Mtb) enters the host in aerosol droplets deposited in lung alveoli, where the bacteria first encounter lung-resident alveolar…”
Get full text

Mycobacteria manipulate macrophage recruitment through coordinated use of membrane lipids by Cambier, C. J., Takaki, Kevin K., Larson, Ryan P., Hernandez, Rafael E., Tobin, David M., Urdahl, Kevin B., Cosma, Christine L., Ramakrishnan, Lalita

“…The bacteria responsible for causing tuberculosis in mammals and zebrafish are shown to preferentially recruit and infect permissive macrophages while evading…”
Get full text

Neutrophils Exert Protection in the Early Tuberculous Granuloma by Oxidative Killing of Mycobacteria Phagocytosed from Infected Macrophages by Yang, Chao-Tsung, Cambier, C.J., Davis, J. Muse, Hall, Christopher J., Crosier, Philip S., Ramakrishnan, Lalita

“…Neutrophils are typically the first responders in host defense against invading pathogens, which they destroy by both oxidative and nonoxidative mechanisms…”
Get full text

A Macrophage Response to Mycobacterium leprae Phenolic Glycolipid Initiates Nerve Damage in Leprosy by Madigan, Cressida A., Cambier, C.J., Kelly-Scumpia, Kindra M., Scumpia, Philip O., Cheng, Tan-Yun, Zailaa, Joseph, Bloom, Barry R., Moody, D. Branch, Smale, Stephen T., Sagasti, Alvaro, Modlin, Robert L., Ramakrishnan, Lalita

“…Mycobacterium leprae causes leprosy and is unique among mycobacterial diseases in producing peripheral neuropathy. This debilitating morbidity is attributed to…”
Get full text

DAP12 is required for macrophage recruitment to the lung in response to cigarette smoke and chemotaxis toward CCL2 by Koth, Laura L, Cambier, C J, Ellwanger, Almut, Solon, Margaret, Hou, Lydia, Lanier, Lewis L, Abram, Clare L, Hamerman, Jessica A, Woodruff, Prescott G

“…DAP12 is an adapter protein that associates with several receptors in macrophages. Little is known about the biological role of DAP12 in alveolar macrophages…”
Get full text

ICOS and Bcl6-dependent pathways maintain a CD4 T cell population with memory-like properties during tuberculosis by Moguche, Albanus O, Shafiani, Shahin, Clemons, Corey, Larson, Ryan P, Dinh, Crystal, Higdon, Lauren E, Cambier, C J, Sissons, James R, Gallegos, Alena M, Fink, Pamela J, Urdahl, Kevin B

“…Immune control of persistent infection with Mycobacterium tuberculosis (Mtb) requires a sustained pathogen-specific CD4 T cell response; however, the molecular…”
Get full text

Cyclopropane Modification of Trehalose Dimycolate Drives Granuloma Angiogenesis and Mycobacterial Growth through Vegf Signaling by Walton, Eric M., Cronan, Mark R., Cambier, C.J., Rossi, Andrea, Marass, Michele, Foglia, Matthew D., Brewer, W. Jared, Poss, Kenneth D., Stainier, Didier Y.R., Bertozzi, Carolyn R., Tobin, David M.

“…Mycobacterial infection leads to the formation of characteristic immune aggregates called granulomas, a process accompanied by dramatic remodeling of the host…”
Get full text

Lysosomal Disorders Drive Susceptibility to Tuberculosis by Compromising Macrophage Migration by Berg, Russell D., Levitte, Steven, O’Sullivan, Mary P., O’Leary, Seónadh M., Cambier, C.J., Cameron, James, Takaki, Kevin K., Moens, Cecilia B., Tobin, David M., Keane, Joseph, Ramakrishnan, Lalita

“…A zebrafish genetic screen for determinants of susceptibility to Mycobacterium marinum identified a hypersusceptible mutant deficient in lysosomal cysteine…”
Get full text