Antioxidant intake and bone status in a cross-sectional study of Brazilian women with osteoporosis

This study aimed to investigate the association between antioxidant intake and bone mineral density (BMD) in postmenopausal women with osteoporosis. We conducted a cross-sectional study with 150 women, mean age 68.7 (SD 9.1) years. BMD and body composition were obtained using dual-energy X-ray absor...

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Bibliographic Details
Published in:	Nutrition and health (Berkhamsted) Vol. 22; no. 2; pp. 133 - 142
Main Authors:	De França, Natasha AG, Camargo, Marilia BR, Lazaretti-Castro, Marise, Martini, Lígia Araújo
Format:	Journal Article
Language:	English
Published:	London, England SAGE Publications 01-04-2013
Subjects:	Absorptiometry, Photon Aged Aged, 80 and over Antioxidants - administration & dosage Body Composition Body Mass Index Bone Density - drug effects Brazil - epidemiology Calcium, Dietary - administration & dosage Cross-Sectional Studies Dietary Supplements Energy Intake Female Humans Lumbar Vertebrae - drug effects Lumbar Vertebrae - metabolism Middle Aged Motor Activity Osteoporosis - drug therapy Osteoporosis - epidemiology Trace Elements Vitamin A - administration & dosage Vitamin D - administration & dosage Vitamins - administration & dosage Waist Circumference Brazil Antioxidants bone mineral density dietary antioxidant quality score vitamin A postmenopausal women lumbar spine osteoporosis
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Summary:	This study aimed to investigate the association between antioxidant intake and bone mineral density (BMD) in postmenopausal women with osteoporosis. We conducted a cross-sectional study with 150 women, mean age 68.7 (SD 9.1) years. BMD and body composition were obtained using dual-energy X-ray absorptiometry (DXA). We assessed anthropometric measures and dietary intake and applied an adapted Dietary Antioxidant Quality Score (a-DAQS) to evaluate the antioxidant consumption. 65.3% of women had higher scores on the a-DAQS. We found no relationship between the a-DAQS and BMD; however, we observed an inverse correlation between vitamin A and lumbar spine (LS) BMD in g/cm2 (r = – 0.201; p = 0.013). An analysis of variance (ANOVA) test also showed that vitamin A was negatively associated with the LS BMD (F = 6.143; p = 0.013, but without significance when a multivariate analysis was applied. The a-DAQS did not have an association with BMD; however, Vitamin A showed a negative correlation with BMD, but such an association disappeared when the other antioxidants were taken together. Our findings encourage an antioxidant-based dietary approach to osteoporosis prevention and treatment, since the negative effect of vitamin A was neutralized by the intake of such nutrients.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0260-1060 2047-945X
DOI:	10.1177/0260106014563445