Search Results - "Camara, Amadou K. S."

Integrated computational model of the bioenergetics of isolated lung mitochondria by Zhang, Xiao, Dash, Ranjan K, Jacobs, Elizabeth R, Camara, Amadou K S, Clough, Anne V, Audi, Said H

“…Integrated computational modeling provides a mechanistic and quantitative framework for describing lung mitochondrial bioenergetics. Thus, the objective of…”
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Modulation of electron transport protects cardiac mitochondria and decreases myocardial injury during ischemia and reperfusion by Chen, Qun, Camara, Amadou K S, Stowe, David F, Hoppel, Charles L, Lesnefsky, Edward J

“…Mitochondria are increasingly recognized as lynchpins in the evolution of cardiac injury during ischemia and reperfusion. This review addresses the emerging…”
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Mitochondria in Health and Diseases by Javadov, Sabzali, Kozlov, Andrey V, Camara, Amadou K S

“…Mitochondria are subcellular organelles evolved by endosymbiosis of bacteria with eukaryotic cells characteristics. They are the main source of ATP in the cell…”
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Mitochondrial Ca2+-induced K+ influx increases respiration and enhances ROS production while maintaining membrane potential by Heinen, André, Camara, Amadou K S, Aldakkak, Mohammed, Rhodes, Samhita S, Riess, Matthias L, Stowe, David F

“…We recently demonstrated a role for altered mitochondrial bioenergetics and reactive oxygen species (ROS) production in mitochondrial Ca(2+)-sensitive K(+)…”
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Mitochondrial VDAC1: A Key Gatekeeper as Potential Therapeutic Target by Camara, Amadou K S, Zhou, YiFan, Wen, Po-Chao, Tajkhorshid, Emad, Kwok, Wai-Meng

“…Mitochondria are the key source of ATP that fuels cellular functions, and they are also central in cellular signaling, cell division and apoptosis. Dysfunction…”
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Reverse electron flow-induced ROS production is attenuated by activation of mitochondrial Ca2+-sensitive K+ channels by Heinen, André, Aldakkak, Mohammed, Stowe, David F, Rhodes, Samhita S, Riess, Matthias L, Varadarajan, Srinivasan G, Camara, Amadou K S

“…Mitochondria generate reactive oxygen species (ROS) dependent on substrate conditions, O(2) concentration, redox state, and activity of the mitochondrial…”
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Mitochondrial targets for volatile anesthetics against cardiac ischemia-reperfusion injury by Agarwal, Bhawana, Stowe, David F, Dash, Ranjan K, Bosnjak, Zeljko J, Camara, Amadou K S

“…Mitochondria are critical modulators of cell function and are increasingly recognized as proximal sensors and effectors that ultimately determine the balance…”
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Computational analysis of Ca2+ dynamics in isolated cardiac mitochondria predicts two distinct modes of Ca2+ uptake by Tewari, Shivendra G., Camara, Amadou K. S., Stowe, David F., Dash, Ranjan K.

“…Key points Cytosolic, but not matrix, Mg2+ inhibits mitochondrial Ca2+ uptake through the Ca2+ uniporter (CU). The majority of mitochondrial Ca2+ uptake under…”
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Modeling the calcium sequestration system in isolated guinea pig cardiac mitochondria by Bazil, Jason N., Blomeyer, Christoph A., Pradhan, Ranjan K., Camara, Amadou K. S., Dash, Ranjan K.

“…Under high Ca 2+ load conditions, Ca 2+ concentrations in the extra-mitochondrial and mitochondrial compartments do not display reciprocal dynamics. This is…”
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Three-dimensional vascular and metabolic imaging using inverted autofluorescence by Mehrvar, Shima, Mostaghimi, Soudeh, Camara, Amadou K. S, Foomani, Farnaz H, Narayanan, Jayashree, Fish, Brian, Medhora, Meetha, Ranji, Mahsa

“…Significance: Three-dimensional (3D) vascular and metabolic imaging (VMI) of whole organs in rodents provides critical and important (patho)physiological…”
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LETM1: A Single Entity With Diverse Impact on Mitochondrial Metabolism and Cellular Signaling by Natarajan, Gayathri K, Mishra, Jyotsna, Camara, Amadou K S, Kwok, Wai-Meng

“…Nearly 2 decades since its discovery as one of the genes responsible for the Wolf-Hirschhorn Syndrome (WHS), the primary function of the leucine-zipper EF-hand…”
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Editorial: Mitochondrial Exchangers and Transporters in Cell Survival and Death by Kwok, Wai-Meng, Tajkhorshid, Emad, Camara, Amadou K S

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Hypothermia augments reactive oxygen species detected in the guinea pig isolated perfused heart by Camara, Amadou K S, Riess, Matthias L, Kevin, Leo G, Novalija, Enis, Stowe, David F

“…Hypothermic perfusion of the heart decreases oxidative phosphorylation and increases NADH. Because O(2) and substrates remain available and respiration…”
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Mitochondrial respiratory supercomplexes in mammalian cells: structural versus functional role by Javadov, Sabzali, Jang, Sehwan, Chapa-Dubocq, Xavier R., Khuchua, Zaza, Camara, Amadou KS

“…Mitochondria are recognized as the main source of ATP to meet the energy demands of the cell. ATP production occurs by oxidative phosphorylation when electrons…”
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Optical metabolic imaging of irradiated rat heart exposed to ischemia-reperfusion injury by la Cour, Mette Funding, Mehrvar, Shima, Heisner, James S, Motlagh, Mohammad Masoudi, Medhora, Meetha, Ranji, Mahsa, Camara, Amadou K. S

“…Whole thoracic irradiation (WTI) is known to cause deterioration in cardiac function. Whether irradiation predisposes the heart to further ischemia and…”
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Knockout of VDAC1 in H9c2 Cells Promotes Oxidative Stress-Induced Cell Apoptosis through Decreased Mitochondrial Hexokinase II Binding and Enhanced Glycolytic Stress by Yang, Meiying, Sun, Jie, Stowe, David F, Tajkhorshid, Emad, Kwok, Wai-Meng, Camara, Amadou K S

“…The role of VDAC1, the most abundant mitochondrial outer membrane protein, in cell death depends on cell types and stimuli. Both silencing and upregulation of…”
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Repetitive Mild Traumatic Brain Injury in Rats Impairs Cognition, Enhances Prefrontal Cortex Neuronal Activity, and Reduces Pre-synaptic Mitochondrial Function by Feng, Yin, Li, Keguo, Roth, Elizabeth, Chao, Dongman, Mecca, Christina M, Hogan, Quinn H, Pawela, Christopher, Kwok, Wai-Meng, Camara, Amadou K S, Pan, Bin

“…A major hurdle preventing effective interventions for patients with mild traumatic brain injury (mTBI) is the lack of known mechanisms for the long-term…”
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Altered NADH and improved function by anesthetic and ischemic preconditioning in guinea pig intact hearts by Riess, Matthias L, Camara, Amadou K S, Chen, Qun, Novalija, Enis, Rhodes, Samhita S, Stowe, David F

“…NADH increases during ischemia because O(2) shortage limits NADH oxidation at the electron transport chain. Ischemic (IPC) and anesthetic preconditioning (APC)…”
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Anesthetic preconditioning: triggering role of reactive oxygen and nitrogen species in isolated hearts by Novalija, Enis, Varadarajan, Srinivasan G, Camara, Amadou K S, An, Jianzhong, Chen, Qun, Riess, Matthias L, Hogg, Neil, Stowe, David F

“…We postulated that anesthetic preconditioning (APC) is triggered by reactive oxygen/nitrogen species (ROS/RNS). We used the isolated guinea pig heart perfused…”
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Structural basis of complex formation between mitochondrial anion channel VDAC1 and Hexokinase-II by Haloi, Nandan, Wen, Po-Chao, Cheng, Qunli, Yang, Meiying, Natarajan, Gayathri, Camara, Amadou K. S., Kwok, Wai-Meng, Tajkhorshid, Emad

“…Complex formation between hexokinase-II (HKII) and the mitochondrial VDAC1 is crucial to cell growth and survival. We hypothesize that HKII first inserts into…”
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