Search Results - "Cam, Margaret"

The transcription factor TCF-1 enforces commitment to the innate lymphoid cell lineage by Harly, Christelle, Kenney, Devin, Ren, Gang, Lai, Binbin, Raabe, Tobias, Yang, Qi, Cam, Margaret C., Xue, Hai-Hui, Zhao, Keji, Bhandoola, Avinash

“…Innate lymphoid cells (ILCs) play important functions in immunity and tissue homeostasis, but their development is poorly understood. Through the use of…”
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Metastatic adrenocortical carcinoma displays higher mutation rate and tumor heterogeneity than primary tumors by Gara, Sudheer Kumar, Lack, Justin, Zhang, Lisa, Harris, Emerson, Cam, Margaret, Kebebew, Electron

“…Adrenocortical cancer (ACC) is a rare cancer with poor prognosis and high mortality due to metastatic disease. All reported genetic alterations have been in…”
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Remodeling the tumor microenvironment via blockade of LAIR-1 and TGF-β signaling enables PD-L1-mediated tumor eradication by Horn, Lucas A, Chariou, Paul L, Gameiro, Sofia R, Qin, Haiyan, Iida, Masafumi, Fousek, Kristen, Meyer, Thomas J, Cam, Margaret, Flies, Dallas, Langermann, Solomon, Schlom, Jeffrey, Palena, Claudia

“…Collagens in the extracellular matrix (ECM) provide a physical barrier to tumor immune infiltration, while also acting as a ligand for immune inhibitory…”
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Tumors produce glucocorticoids by metabolite recycling, not synthesis, and activate Tregs to promote growth by Taves, Matthew D, Otsuka, Shizuka, Taylor, Michaela A, Donahue, Kaitlynn M, Meyer, Thomas J, Cam, Margaret C, Ashwell, Jonathan D

“…Glucocorticoids are steroid hormones with potent immunosuppressive properties. Their primary source is the adrenals, where they are generated via de novo…”
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Age-specific signatures of glioblastoma at the genomic, genetic, and epigenetic levels by Bozdag, Serdar, Li, Aiguo, Riddick, Gregory, Kotliarov, Yuri, Baysan, Mehmet, Iwamoto, Fabio M, Cam, Margaret C, Kotliarova, Svetlana, Fine, Howard A

“…Age is a powerful predictor of survival in glioblastoma multiforme (GBM) yet the biological basis for the difference in clinical outcome is mostly unknown…”
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Natural Killer Cell Recruitment and Activation Are Regulated by CD47 Expression in the Tumor Microenvironment by Nath, Pulak Ranjan, Pal-Nath, Dipasmita, Mandal, Ajeet, Cam, Margaret C, Schwartz, Anthony L, Roberts, David D

“…Elevated CD47 expression in some cancers is associated with decreased survival and limited clearance by phagocytes expressing the CD47 counterreceptor SIRPα…”
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Tumour-targeted interleukin-12 and entinostat combination therapy improves cancer survival by reprogramming the tumour immune cell landscape by Hicks, Kristin C., Chariou, Paul L., Ozawa, Yohei, Minnar, Christine M., Knudson, Karin M., Meyer, Thomas J., Bian, Jing, Cam, Margaret, Schlom, Jeffrey, Gameiro, Sofia R.

“…Poorly inflamed carcinomas do not respond well to immune checkpoint blockade. Converting the tumour microenvironment into a functionally inflamed immune hub…”
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Induction of DNMT3B by PGE2 and IL6 at Distant Metastatic Sites Promotes Epigenetic Modification and Breast Cancer Colonization by So, Jae Young, Skrypek, Nicolas, Yang, Howard H, Merchant, Anand S, Nelson, George W, Chen, Wei-Dong, Ishii, Hiroki, Chen, Jennifer M, Hu, Gangqing, Achyut, Bhagelu R, Yoon, Esther C, Han, Liying, Huang, Chuanshu, Cam, Margaret C, Zhao, Keji, Lee, Maxwell P, Yang, Li

“…Current cancer treatments are largely based on the genetic characterization of primary tumors and are ineffective for metastatic disease. Here we report that…”
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CD47-Dependent Regulation of Immune Checkpoint Gene Expression and MYCN mRNA Splicing in Murine CD8 and Jurkat T Cells by Kaur, Sukhbir, Awad, Duha, Finney, Richard P, Meyer, Thomas J, Singh, Satya P, Cam, Margaret C, Karim, Baktiar O, Warner, Andrew C, Roberts, David D

“…Elevated expression of CD47 in some cancers is associated with poor survival related to its function as an innate immune checkpoint when expressed on tumor…”
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NFκB Promotes Ovarian Tumorigenesis via Classical Pathways That Support Proliferative Cancer Cells and Alternative Pathways That Support ALDH + Cancer Stem-like Cells by House, Carrie D, Jordan, Elizabeth, Hernandez, Lidia, Ozaki, Michelle, James, Jana M, Kim, Marianne, Kruhlak, Michael J, Batchelor, Eric, Elloumi, Fathi, Cam, Margaret C, Annunziata, Christina M

“…Understanding the mechanisms supporting tumor-initiating cells (TIC) is vital to combat advanced-stage recurrent cancers. Here, we show that in advanced…”
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Coordinated gene expression of neuroinflammatory and cell signaling markers in dorsolateral prefrontal cortex during human brain development and aging by Primiani, Christopher T, Ryan, Veronica H, Rao, Jagadeesh S, Cam, Margaret C, Ahn, Kwangmi, Modi, Hiren R, Rapoport, Stanley I

“…Age changes in expression of inflammatory, synaptic, and neurotrophic genes are not well characterized during human brain development and senescence. Knowing…”
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HIV vaccine candidate efficacy in female macaques mediated by cAMP-dependent efferocytosis and V2-specific ADCC by Bissa, Massimiliano, Kim, Sohyoung, Galli, Veronica, Fourati, Slim, Sarkis, Sarkis, Arakelyan, Anush, de Castro, Isabela Silva, Rahman, Mohammad Arif, Fujiwara, Saori, Vaccari, Monica, Tomalka, Jeffrey A., Stamos, James D., Schifanella, Luca, Gorini, Giacomo, Moles, Ramona, Gutowska, Anna, Ferrari, Guido, Lobanov, Alexei, Montefiori, David C., Nelson, George W., Cam, Margaret C., Chakhtoura, Marita, Haddad, Elias K., Doster, Melvin N., McKinnon, Katherine, Brown, Sophia, Venzon, David J., Choo-Wosoba, Hyoyoung, Breed, Matthew W., Killoran, Kristin E., Kramer, Joshua, Margolis, Leonid, Sekaly, Rafick P., Hager, Gordon L., Franchini, Genoveffa

“…The development of an effective vaccine to protect against HIV acquisition will be greatly bolstered by in-depth understanding of the innate and adaptive…”
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Loss of CD47 alters CD8+ T cell activation in vitro and immunodynamics in mice by Nath, Pulak R., Pal-Nath, Dipasmita, Kaur, Sukhbir, Gangaplara, Arunkumar, Meyer, Thomas J., Cam, Margaret C, Roberts, David D.

“…CD47 has established roles in the immune system for regulating macrophage phagocytosis and lymphocyte activation, with growing evidence of its cell-intrinsic…”
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Micro-environment causes reversible changes in DNA methylation and mRNA expression profiles in patient-derived glioma stem cells by Baysan, Mehmet, Woolard, Kevin, Bozdag, Serdar, Riddick, Gregory, Kotliarova, Svetlana, Cam, Margaret C, Belova, Galina I, Ahn, Susie, Zhang, Wei, Song, Hua, Walling, Jennifer, Stevenson, Holly, Meltzer, Paul, Fine, Howard A

“…In vitro and in vivo models are widely used in cancer research. Characterizing the similarities and differences between a patient's tumor and corresponding in…”
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Detailed longitudinal sampling of glioma stem cells in situ reveals Chr7 gain and Chr10 loss as repeated events in primary tumor formation and recurrence by Baysan, Mehmet, Woolard, Kevin, Cam, Margaret C., Zhang, Wei, Song, Hua, Kotliarova, Svetlana, Balamatsias, Demosthenes, Linkous, Amanda, Ahn, Susie, Walling, Jennifer, Belova, Galina I., Fine, Howard A.

“…Intratumoral heterogeneity at the genetic, epigenetic, transcriptomic, and morphologic levels is a commonly observed phenomenon in many aggressive cancer…”
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G-cimp status prediction of glioblastoma samples using mRNA expression data by Baysan, Mehmet, Bozdag, Serdar, Cam, Margaret C, Kotliarova, Svetlana, Ahn, Susie, Walling, Jennifer, Killian, Jonathan K, Stevenson, Holly, Meltzer, Paul, Fine, Howard A

“…Glioblastoma Multiforme (GBM) is a tumor with high mortality and no known cure. The dramatic molecular and clinical heterogeneity seen in this tumor has led to…”
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Loss of signal transducer and activator of transcription 5 leads to hepatosteatosis and impaired liver regeneration by Cui, Yongzhi, Hosui, Atsushi, Sun, Rui, Shen, Kezhen, Gavrilova, Oksana, Chen, Weiping, Cam, Margaret C., Gao, Bin, Robinson, Gertraud W., Hennighausen, Lothar

“…Growth hormone controls many facets of a cell's biology through the transcription factors Stat5a and Stat5b (Stat5). However, whole body deletion of these…”
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5-Azacytidine prevents relapse and produces long-term complete remissions in leukemia xenografts treated with Moxetumomab pasudotox by Müller, Fabian, Cunningham, Tyler, Stookey, Stephanie, Tai, Chin-Hsien, Burkett, Sandra, Jailwala, Parthav, Stevenson, Maryalice Stetler, Cam, Margaret C., Wayne, Alan S., Pastan, Ira

“…Moxetumomab pasudotox (Moxe) is a chimeric protein composed of an anti-CD22 Fv fused to a portion of Pseudomonas exotoxin A and kills CD22-expressing leukemia…”
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Single-Cell-Derived Primary Rectal Carcinoma Cell Lines Reflect Intratumor Heterogeneity Associated with Treatment Response by Braun, Rüdiger, Anthuber, Lena, Hirsch, Daniela, Wangsa, Darawalee, Lack, Justin, McNeil, Nicole E, Heselmeyer-Haddad, Kerstin, Torres, Irianna, Wangsa, Danny, Brown, Markus A, Tubbs, Anthony, Auslander, Noam, Gertz, E Michael, Brauer, Philip R, Cam, Margaret C, Sackett, Dan L, Habermann, Jens K, Nussenzweig, Andre, Ruppin, Eytan, Zhang, Zhongqiu, Rosenberg, Daniel W, Ried, Thomas

“…The standard treatment of patients with locally advanced rectal cancer consists of preoperative chemoradiotherapy (CRT) followed by surgery. However, the…”
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Aire drives steroid hormone biosynthesis by medullary thymic epithelial cells by Taves, Matthew D, Donahue, Kaitlynn M, Bian, Jing, Cam, Margaret C, Ashwell, Jonathan D

“…Thymic epithelial cells (TECs) produce glucocorticoids, which antagonize negative selection of autoreactive thymocytes and promote a competent T cell…”
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