Search Results - "Calzone, Frank J."

AMG 479, a fully human anti–insulin-like growth factor receptor type I monoclonal antibody, inhibits the growth and survival of pancreatic carcinoma cells by Beltran, Pedro J, Mitchell, Petia, Chung, Young-A, Cajulis, Elaina, Lu, John, Belmontes, Brian, Ho, Joanne, Tsai, Mei Mei, Zhu, Min, Vonderfecht, Steven, Baserga, Renato, Kendall, Richard, Radinsky, Robert, Calzone, Frank J

“…Pancreatic carcinoma is a leading cause of cancer deaths, and recent clinical trials of a number of oncology therapeutics have not substantially improved…”
Get full text

HER2 and HLA-A02 dual CAR-T cells utilize LOH in a NOT logic gate to address on-target off-tumor toxicity by Bassan, David, Weinberger, Leehee, Yi, Jason, Kim, Tanya, Weist, Michael R, Adams, Gregor B, Foord, Orit, Chaim, Neta, Tabak, Sarit, Bujanover, Nir, Lopesco, Yael, Vucci, Kristina, Schnair, Caitlin, Levy-Knafo, Limor, Kendall, Richard L, Calzone, Frank J, Sharbi-Yunger, Adi

“…BackgroundOne of the major challenges in chimeric antigen receptor (CAR)-T cell therapy for solid tumors is the potential for on-target off-tumor toxicity due…”
Get full text

Epitope-specific mechanisms of IGF1R inhibition by ganitumab by Calzone, Frank J, Cajulis, Elaina, Chung, Young-Ah, Tsai, Mei-Mei, Mitchell, Petia, Lu, John, Chen, Ching, Sun, Jilin, Radinsky, Robert, Kendall, Richard, Beltran, Pedro J

“…Therapeutic antibodies targeting the IGF1R have shown diverse efficacy and safety signals in oncology clinical trials. The success of these agents as future…”
Get full text

Localization of human BRCA1 and its loss in high-grade, non-inherited breast carcinomas by Slamon, Dennis J, Wilson, Cindy A, Ramos, Lillian, Villaseñor, Maria R, Anders, Karl H, Press, Michael F, Clarke, Kathy, Karlan, Beth, Chen, Jun-Jie, Scully, Ralph, Livingston, David, Zuch, Robert H, Kanter, Michael H, Cohen, Sylvan, Calzone, Frank J

“…Although the link between the BRCA1 tumour-suppressor gene and hereditary breast and ovarian cancer is established, the role, if any, of BRCA1 in non-familial…”
Get full text

Differential subcellular localization, expression and biological toxicity of BRCA1 and the splice variant BRCA1-Δ11b by WILSON, C. A, PAYTON, M. N, ELLIOTT, G. S, BUAAS, F. W, CAJULIS, E. E, GROSSHANS, D, RAMOS, L, REESE, D. M, SLAMON, D. J, CALZONE, F. J

Get full text

Efficacy of ganitumab (AMG 479), alone and in combination with rapamycin, in Ewing's and osteogenic sarcoma models by Beltran, Pedro J, Chung, Young-Ah, Moody, Gordon, Mitchell, Petia, Cajulis, Elaina, Vonderfecht, Steven, Kendall, Richard, Radinsky, Robert, Calzone, Frank J

“…Ewing's and osteogenic sarcoma are two of the leading causes of cancer deaths in children and adolescents. Recent data suggest that sarcomas may depend on the…”
Get more information

Ganitumab (AMG 479) Inhibits IGF-II-Dependent Ovarian Cancer Growth and Potentiates Platinum-Based Chemotherapy by BELTRAN, Pedro J, CALZONE, Frank J, GUORONG YANG, JINGWEI QI, SLAMON, Dennis J, KONECNY, Gottfried E, MITCHELL, Petia, CHUNG, Young-Ah, CAJULIS, Elaina, MOODY, Gordon, BELMONTES, Brian, LI, Chi-Ming, VONDERFECHT, Steven, VELCULESCU, Victor E

“…Insulin-like growth factor 1 receptor (IGF-IR) has been implicated in the pathogenesis of ovarian cancer. Ganitumab is an investigational, fully human…”
Get full text

IGF1R blockade with ganitumab results in systemic effects on the GH–IGF axis in mice by Moody, Gordon, Beltran, Pedro J, Mitchell, Petia, Cajulis, Elaina, Chung, Young-Ah, Hwang, David, Kendall, Richard, Radinsky, Robert, Cohen, Pinchas, Calzone, Frank J

“…Ganitumab is a fully human MAB to the human type 1 IGF receptor (IGF1R). Binding assays showed that ganitumab recognized murine IGF1R with sub-nanomolar…”
Get full text

Effect of a low-fat diet combined with IGF-1 receptor blockade on 22Rv1 prostate cancer xenografts by Konijeti, Ramdev, Koyama, Satomi, Gray, Ashley, Barnard, R James, Said, Jonathan W, Castor, Brandon, Elashoff, David, Wan, Junxiang, Beltran, Pedro J, Calzone, Frank J, Cohen, Pinchas, Galet, Colette, Aronson, William J

“…In preclinical models, both dietary fat reduction and insulin-like growth factor I receptor (IGF-1R) blockade individually inhibit prostate cancer xenograft…”
Get full text

HER-2 overexpression differentially alters transforming growth factor-beta responses in luminal versus mesenchymal human breast cancer cells by Wilson, Cindy A, Cajulis, Elaina E, Green, Jennifer L, Olsen, Taylor M, Chung, Young Ah, Damore, Michael A, Dering, Judy, Calzone, Frank J, Slamon, Dennis J

“…Amplification of the HER-2 receptor tyrosine kinase has been implicated in the pathogenesis and aggressive behavior of approximately 25% of invasive human…”
Get full text

Novel consensus DNA-binding sequence for BRCA1 protein complexes by Cable, P. LouAnn, Wilson, Cindy A., Calzone, Frank J., Rauscher III, Frank J., Scully, Ralph, Livingston, David M., Li, Leping, Blackwell, Courtney B., Futreal, P. Andrew, Afshari, Cynthia A.

“…Increasing evidence continues to emerge supporting the early hypothesis that BRCA1 might be involved in transcriptional processes. BRCA1 physically associates…”
Get full text

BRCA1 protein products: Antibody specificity by Wilson, Cindy A, Payton, Marc N, Pekar, Susan K, Zhang, Ke, Pacifici, Robert E, Gudas, Jean L, Thukral, Sushil, Calzone, Frank J, Reese, David M, Slamon, Dennis I

“…The recent publication of Chen et al. and Jensen et al. have generated conflicting views of BRCA1 protein kinesis that must be resolved before the functional…”
Get full text

Abstract 2848: Incorporation of inhibitory signaling domains into chimeric antigen receptors (iCAR) designed for self-regulation of canonical CAR-T to treat solid tumors by Bassan, David, Yi, Jason, Chaim, Neta, Bujanover, Nir, Tabak, Sarit, Kim, Tanya, Lopesco, Yael, Weinberger, Leehee, Vucci, Kristina, Weist, Michael, Schnair, Caitlin, Adams, Gregor B., Foord, Orit, Calzone, Frank J., Kendall, Rick, Sharbi-Yunger, Adi

“…Abstract Chimeric antigen receptor (CAR)-T cell therapy is a groundbreaking cancer treatment that has produced remarkable clinical efficacy for hematopoietic…”
Get full text

Abstract 2826: Rewiring CAR T-cells for absolute solid tumor specificity and safety by Weist, Michael R., Sharbi-Yunger, Adi, Yi, Jason, Schnair, Caitlin, Bassan, David, Kim, Tanya, Tabak, Sarit, Lopesco, Yael, Weinberger, Leehee, Bujanover, Nir, Chaim, Neta, Vucci, Kristina, Foord, Orit, Calzone, Frank J., Kendall, Rick, Adams, Gregor B.

“…Abstract Translation of the unprecedented efficacy of chimeric antigen receptor (CAR) T-cell technology into solid tumors requires a solution to the problem of…”
Get full text

Abstract C55: Ganitumab (AMG 479) inhibits the development and progression of castration-resistant VCaP human prostate cancer xenografts by Fahrenholtz, Cale D., Beltran, Pedro J., Calzone, Frank J., Burnstein, Kerry L.

“…Abstract Prostate tumors are initially dependent on androgens for growth; thus the standard of care for advanced or metastatic prostate cancer is androgen…”
Get full text

Complexity of Sea Urchin Embryo Nuclear Proteins That Contain Basic Domains by Harrington, Michael G., Coffman, James A., Calzone, Frank J., Hood, Leroy E., Britten, Roy J., Davidson, Eric H.

“…We describe a quantitative two-dimensional gel electrophoretic analysis of nuclear extract from 24-hr sea urchin embryos. The extract was fractionated by using…”
Get full text

Abstract C172: Efficacy of AMG 479, alone and in combination with cisplatin, in ovarian carcinoma xenograft models by Beltran, Pedro J., Mitchell, Petia, Cajulis, Elaina, Moody, Gordon, Chung, Young-Ah, Wang, Jon, Belmontes, Brian, Radinsky, Robert, Calzone, Frank J.

“…Abstract AMG 479, a fully human monoclonal antibody raised to the type I insulin-like growth factor receptor (IGF1R), is currently being studied in the…”
Get full text

Regulation of protein synthesis in Tetrahymena: isolation and characterization of polysomes by gel filtration and precipitation at pH 5.3 by Calzone, Frank J., Angerer, Robert C., Gorovsky, Martin A.

“…The fraction of ribosomes loaded on polysomes is about 95% in logarithmically growing Tetrahymena thermophila, and about 4% in starved cells. Cytoplasmic…”
Get full text

Mapping of gene transcripts by nuclease protection assays and cDNA primer extension by Calzone, F J, Britten, R J, Davidson, E H

Get more information

Gene regulatory factors of the sea urchin embryo. I. Purification by affinity chromatography and cloning of P3A2, a novel DNA-binding protein by CALZONE, F. J, HOOG, C, TEPLOW, D. B, CUTTING, A. E, ZELLER, R. W, BRITTEN, R. J, DAVIDSON, R. H

“…The P3A2 regulatory protein interacts with specific sites in the control region of the CyIIIa actin gene. Previous studies showed that this interaction is…”
Get full text