Search Results - "Calvin, J"

Can we contain the COVID-19 outbreak with the same measures as for SARS? by Wilder-Smith, Annelies, Chiew, Calvin J, Lee, Vernon J

“…The severe acute respiratory syndrome (SARS) outbreak in 2003 resulted in more than 8000 cases and 800 deaths. SARS was eventually contained by means of…”
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Organoid Models of Tumor Immunology by Yuki, Kanako, Cheng, Ning, Nakano, Michitaka, Kuo, Calvin J.

“…Cellular interactions in the tumor microenvironment (TME) significantly govern cancer progression and drug response. The efficacy of clinical immunotherapies…”
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Interrupting transmission of COVID-19: lessons from containment efforts in Singapore by Lee, Vernon J, Chiew, Calvin J, Khong, Wei Xin

“…Despite multiple importations resulting in local chains of transmission, Singapore has been able to control the COVID-19 outbreak without major disruption to…”
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Decreased Influenza Incidence under COVID-19 Control Measures, Singapore by Soo, Roy Jiunn Jye, Chiew, Calvin J, Ma, Stefan, Pung, Rachael, Lee, Vernon

“…We compared indicators of influenza activity in 2020 before and after public health measures were taken to reduce coronavirus disease (COVID-19) with the…”
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The antiviral compound remdesivir potently inhibits RNA-dependent RNA polymerase from Middle East respiratory syndrome coronavirus by Gordon, Calvin J., Tchesnokov, Egor P., Feng, Joy Y., Porter, Danielle P., Götte, Matthias

“…Antiviral drugs for managing infections with human coronaviruses are not yet approved, posing a serious challenge to current global efforts aimed at containing…”
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Molnupiravir promotes SARS-CoV-2 mutagenesis via the RNA template by Gordon, Calvin J., Tchesnokov, Egor P., Schinazi, Raymond F., Götte, Matthias

“…The RNA-dependent RNA polymerase of the severe acute respiratory syndrome coronavirus 2 is an important target in current drug development efforts for the…”
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Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome coronavirus 2 with high potency by Gordon, Calvin J., Tchesnokov, Egor P., Woolner, Emma, Perry, Jason K., Feng, Joy Y., Porter, Danielle P., Götte, Matthias

“…Effective treatments for coronavirus disease 2019 (COVID-19) are urgently needed to control this current pandemic, caused by severe acute respiratory syndrome…”
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Plant-Derived Lectins as Potential Cancer Therapeutics and Diagnostic Tools by Mazalovska, Milena, Kouokam, J. Calvin

“…Cancer remains a global health challenge, with high morbidity and mortality, despite the recent advances in diagnosis and treatment. Multiple compounds…”
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Controlling Epithelial Polarity: A Human Enteroid Model for Host-Pathogen Interactions by Co, Julia Y., Margalef-Català, Mar, Li, Xingnan, Mah, Amanda T., Kuo, Calvin J., Monack, Denise M., Amieva, Manuel R.

“…Human enteroids—epithelial spheroids derived from primary gastrointestinal tissue—are a promising model to study pathogen-epithelial interactions. However,…”
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Comparison of Ankle Fracture Fixation Using Intramedullary Fibular Nailing Versus Plate Fixation by Rushing, Calvin J.

“…Ankle fracture fixation using intramedullary fibular (IMF) nails has been shown to allow for earlier weightbearing, reduced wound complications, better union…”
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Clinical and Virological Features of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Variants of Concern: A Retrospective Cohort Study Comparing B.1.1.7 (Alpha), B.1.351 (Beta), and B.1.617.2 (Delta) by Ong, Sean Wei Xiang, Chiew, Calvin J, Ang, Li Wei, Mak, Tze Minn, Cui, Lin, Toh, Matthias Paul H S, Lim, Yi Ding, Lee, Pei Hua, Lee, Tau Hong, Chia, Po Ying, Maurer-Stroh, Sebastian, Lin, Raymond T P, Leo, Yee Sin, Lee, Vernon J, Lye, David Chien, Young, Barnaby Edward

“…Abstract Background The impact of SARS-CoV-2 variants of concern (VOCs) on disease severity is unclear. In this retrospective study, we compared the outcomes…”
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Fluorescence Imaging In Vivo at Wavelengths beyond 1500 nm by Diao, Shuo, Blackburn, Jeffrey L., Hong, Guosong, Antaris, Alexander L., Chang, Junlei, Wu, Justin Z., Zhang, Bo, Cheng, Kai, Kuo, Calvin J., Dai, Hongjie

“…Compared to imaging in the visible and near‐infrared regions below 900 nm, imaging in the second near‐infrared window (NIR‐II, 1000–1700 nm) is a promising…”
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Mesenteric-based surgery for Crohn’s disease: evidence and perspectives by Duan, Ming, Coffey, J. Calvin, Li, Yi

“…Postoperative anastomotic recurrence of Crohn’s disease is challenging and can lead to symptom recurrence and further surgery. The mesenteric pole of the…”
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The Intestinal Stem Cell Niche: Homeostasis and Adaptations by Santos, António J.M., Lo, Yuan-Hung, Mah, Amanda T., Kuo, Calvin J.

“…The intestinal epithelium is a rapidly renewing cellular compartment. This constant regeneration is a hallmark of intestinal homeostasis and requires a tightly…”
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Through-skull fluorescence imaging of the brain in a new near-infrared window by Hong, Guosong, Diao, Shuo, Chang, Junlei, Antaris, Alexander L., Chen, Changxin, Zhang, Bo, Zhao, Su, Atochin, Dmitriy N., Huang, Paul L., Andreasson, Katrin I., Kuo, Calvin J., Dai, Hongjie

“…To date, brain imaging has largely relied on X-ray computed tomography and magnetic resonance angiography, with their limited spatial resolution and long…”
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The HIF Signaling Pathway in Osteoblasts Directly Modulates Erythropoiesis through the Production of EPO by Rankin, Erinn B., Wu, Colleen, Khatri, Richa, Wilson, Tremika L.S., Andersen, Rebecca, Araldi, Elisa, Rankin, Andrew L., Yuan, Jenny, Kuo, Calvin J., Schipani, Ernestina, Giaccia, Amato J.

“…Osteoblasts are an important component of the hematopoietic microenvironment in bone. However, the mechanisms by which osteoblasts control hematopoiesis remain…”
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The abundance of Akkermansia muciniphila and its relationship with sulphated colonic mucins in health and ulcerative colitis by Earley, Helen, Lennon, Grainne, Balfe, Áine, Coffey, J. Calvin, Winter, Desmond C., O’Connell, P. Ronan

“…Akkermansia muciniphila utilises colonic mucin as its substrate. Abundance is reduced in ulcerative colitis (UC), as is the relative proportion of sulphated…”
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Wnt pathway regulation of intestinal stem cells by Mah, Amanda T., Yan, Kelley S., Kuo, Calvin J.

“…Wnt signalling is involved in multiple aspects of embryonic development and adult tissue homeostasis, notably via controlling cellular proliferation and…”
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Organoid Modeling of the Tumor Immune Microenvironment by Neal, James T., Li, Xingnan, Zhu, Junjie, Giangarra, Valeria, Grzeskowiak, Caitlin L., Ju, Jihang, Liu, Iris H., Chiou, Shin-Heng, Salahudeen, Ameen A., Smith, Amber R., Deutsch, Brian C., Liao, Lillian, Zemek, Allison J., Zhao, Fan, Karlsson, Kasper, Schultz, Liora M., Metzner, Thomas J., Nadauld, Lincoln D., Tseng, Yuen-Yi, Alkhairy, Sahar, Oh, Coyin, Keskula, Paula, Mendoza-Villanueva, Daniel, De La Vega, Francisco M., Kunz, Pamela L., Liao, Joseph C., Leppert, John T., Sunwoo, John B., Sabatti, Chiara, Boehm, Jesse S., Hahn, William C., Zheng, Grace X.Y., Davis, Mark M., Kuo, Calvin J.

“…In vitro cancer cultures, including three-dimensional organoids, typically contain exclusively neoplastic epithelium but require artificial reconstitution to…”
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Virological and serological kinetics of SARS-CoV-2 Delta variant vaccine breakthrough infections: a multicentre cohort study by Chia, Po Ying, Ong, Sean Wei Xiang, Chiew, Calvin J., Ang, Li Wei, Chavatte, Jean-Marc, Mak, Tze-Minn, Cui, Lin, Kalimuddin, Shirin, Chia, Wan Ni, Tan, Chee Wah, Chai, Louis Yi Ann, Tan, Seow Yen, Zheng, Shuwei, Lin, Raymond Tzer Pin, Wang, Linfa, Leo, Yee-Sin, Lee, Vernon J., Lye, David Chien, Young, Barnaby Edward

“…Highly effective vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been developed but variants of concerns are worrisome,…”
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