Search Results - "Calver, Brian L."

Inflammation and frailty measures in older people by Hubbard, Ruth E., O’Mahony, M. Sinead, Savva, George M., Calver, Brian L., Woodhouse, Ken W.

“…Inflammation in patients defined as frail by Fried’s phenotypic definition may be related to sarcopenia. This study aimed to investigate inflammation in older…”
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Nutrition, Inflammation, and Leptin Levels in Aging and Frailty by Hubbard, Ruth E., O'Mahony, M. Sinead, Calver, Brian L., Woodhouse, Ken W.

“…OBJECTIVES: To examine nutritional indices and levels of leptin and inflammatory markers across age and frailty. DESIGN: Observational study. SETTING:…”
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Life-threatening arrhythmogenic CaM mutations disrupt CaM binding to a distinct RyR2 CaM-binding pocket by Thanassoulas, Angelos, Vassilakopoulou, Vyronia, Calver, Brian L., Buntwal, Luke, Smith, Adrian, Lai, Christopher, Kontogianni, Iris, Livaniou, Evangelia, Nounesis, George, Lai, F. Anthony, Nomikos, Michail

“…Calmodulin (CaM) modulates the activity of several proteins that play a key role in excitation-contraction coupling (ECC). In cardiac muscle, the major binding…”
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Divergent Biochemical Properties and Disparate Impact of Arrhythmogenic Calmodulin Mutations on Zebrafish Cardiac Function by Da'as, Sahar I., Thanassoulas, Angelos, Calver, Brian L., Saleh, Alaaeldin, Abdelrahman, Doua, Hasan, Waseem, Safieh‐Garabedian, Bared, Kontogianni, Iris, Nasrallah, Gheyath K., Nounesis, George, Lai, F. Anthony, Nomikos, Michail

“…Calmodulin (CaM) is a ubiquitous, small cytosolic calcium (Ca2+)‐binding sensor that plays a vital role in many cellular processes by binding and regulating…”
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Male infertility-linked point mutation reveals a vital binding role for the C2 domain of sperm PLCζ by Nomikos, Michail, Stamatiadis, Panagiotis, Sanders, Jessica R, Beck, Konrad, Calver, Brian L, Buntwal, Luke, Lofty, Morgan, Sideratou, Zili, Swann, Karl, Lai, F Anthony

“…Sperm-specific phospholipase C zeta (PLCζ) is widely considered to be the physiological stimulus that evokes intracellular calcium (Ca ) oscillations that are…”
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Essential Role of the EF-hand Domain in Targeting Sperm Phospholipase Cζ to Membrane Phosphatidylinositol 4,5-Bisphosphate (PIP2) by Nomikos, Michail, Sanders, Jessica R., Parthimos, Dimitris, Buntwal, Luke, Calver, Brian L., Stamatiadis, Panagiotis, Smith, Adrian, Clue, Matthew, Sideratou, Zili, Swann, Karl, Lai, F. Anthony

“…Sperm-specific phospholipase C-ζ (PLCζ) is widely considered to be the physiological stimulus that triggers intracellular Ca2+ oscillations and egg activation…”
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Antigen unmasking enhances visualization efficacy of the oocyte activation factor, phospholipase C zeta, in mammalian sperm by Kashir, Junaid, Buntwal, Luke, Nomikos, Michail, Calver, Brian L, Stamatiadis, Panagiotis, Ashley, Peter, Vassilakopoulou, Vyronia, Sanders, David, Knaggs, Paul, Livaniou, Evangelia, Bunkheila, Adnan, Swann, Karl, Lai, F Anthony

“…Is it possible to improve clinical visualization of phospholipase C zeta (PLCζ) as a diagnostic marker of sperm oocyte activation capacity and male fertility?…”
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Distinctive malfunctions of calmodulin mutations associated with heart RyR2-mediated arrhythmic disease by Vassilakopoulou, Vyronia, Calver, Brian L., Thanassoulas, Angelos, Beck, Konrad, Hu, Handan, Buntwal, Luke, Smith, Adrian, Theodoridou, Maria, Kashir, Junaid, Blayney, Lynda, Livaniou, Evangelia, Nounesis, George, Lai, F. Anthony, Nomikos, Michail

“…Calmodulin (CaM) is a cytoplasmic calcium sensor that interacts with the cardiac ryanodine receptor (RyR2), a large Ca2+ channel complex that mediates Ca2+…”
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Phospholipase Cζ binding to PtdIns(4,5)P2 requires the XY-linker region by Nomikos, Michail, Elgmati, Khalil, Theodoridou, Maria, Calver, Brian L, Nounesis, George, Swann, Karl, Lai, F Anthony

“…Phospholipase C-zeta (PLCζ) is a strong candidate for the mammalian sperm-derived factor that triggers the Ca(2+) oscillations required for egg activation at…”
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Human PLCζ exhibits superior fertilization potency over mouse PLCζ in triggering the Ca(2+) oscillations required for mammalian oocyte activation by Nomikos, Michail, Theodoridou, Maria, Elgmati, Khalil, Parthimos, Dimitris, Calver, Brian L, Buntwal, Luke, Nounesis, George, Swann, Karl, Lai, F Anthony

“…A sperm-specific phospholipase C-zeta (PLCζ) is believed to play an essential role in oocyte activation during mammalian fertilization. Sperm PLCζ has been…”
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Altered RyR2 regulation by the calmodulin F90L mutation associated with idiopathic ventricular fibrillation and early sudden cardiac death by Nomikos, Michail, Thanassoulas, Angelos, Beck, Konrad, Vassilakopoulou, Vyronia, Hu, Handan, Calver, Brian L., Theodoridou, Maria, Kashir, Junaid, Blayney, Lynda, Livaniou, Evangelia, Rizkallah, Pierre, Nounesis, George, Lai, F. Anthony

“…•A calmodulin mutation (CaMF90L) linked to sudden cardiac death was characterized.•CaMF90L has reduced protein stability, Ca2+ binding affinity and…”
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Mutations in PLCδ1 associated with hereditary leukonychia display divergent PIP2 hydrolytic function by Nomikos, Michail, Thanassoulas, Angelos, Beck, Konrad, Theodoridou, Maria, Kew, Jasmine, Kashir, Junaid, Calver, Brian L., Matthews, Emily, Rizkallah, Pierre, Sideratou, Zili, Nounesis, George, Lai, F. Anthony

“…Hereditary leukonychia is a rare genetic nail disorder characterized by distinctive whitening of the nail plate of all 20 nails. Hereditary leukonychia may…”
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Arrhythmogenic calmodulin E105A mutation alters cardiac RyR2 regulation leading to cardiac dysfunction in zebrafish by Da'as, Sahar I., Thanassoulas, Angelos, Calver, Brian L., Beck, Konrad, Salem, Rola, Saleh, Alaaeldin, Kontogianni, Iris, Al‐Maraghi, Ali, Nasrallah, Gheyath K., Safieh‐Garabedian, Bared, Toft, Egon, Nounesis, George, Lai, F. Anthony, Nomikos, Michail

“…Calmodulin (CaM) is a universal calcium (Ca2+)‐binding messenger that regulates many vital cellular events. In cardiac muscle, CaM associates with ryanodine…”
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Plasma esterases and inflammation in ageing and frailty by Hubbard, Ruth E., O’Mahony, M. Sinead, Calver, Brian L., Woodhouse, Ken W.

“…Objectives Esterases are enzymes of drug metabolism known to be reduced in frail older people and during acute illness. The mechanism for this is unknown. The…”
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Drug Inhibition of Redox Factor-1 Restores Hypoxia-Driven Changes in Tuberous Sclerosis Complex 2 Deficient Cells by Champion, Jesse D, Dodd, Kayleigh M, Lam, Hilaire C, Alzahrani, Mohammad A M, Seifan, Sara, Rad, Ellie, Scourfield, David Oliver, Fishel, Melissa L, Calver, Brian L, Ager, Ann, Henske, Elizabeth P, Davies, David Mark, Kelley, Mark R, Tee, Andrew R

“…Therapies with the mechanistic target of rapamycin complex 1 (mTORC1) inhibitors are not fully curative for tuberous sclerosis complex (TSC) patients. Here, we…”
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Chimeras of sperm PLCζ reveal disparate protein domain functions in the generation of intracellular Ca2+ oscillations in mammalian eggs at fertilization by Theodoridou, Maria, Nomikos, Michail, Parthimos, Dimitris, Gonzalez-Garcia, J Raul, Elgmati, Khalil, Calver, Brian L, Sideratou, Zili, Nounesis, George, Swann, Karl, Lai, F Anthony

“…Phospholipase C-zeta (PLCζ) is a sperm-specific protein believed to cause Ca(2+) oscillations and egg activation during mammalian fertilization. PLCζ is very…”
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Phospholipase Cζ binding to PtdIns(4,5) P 2 requires the XY-linker region by Nomikos, Michail, Elgmati, Khalil, Theodoridou, Maria, Calver, Brian L., Nounesis, George, Swann, Karl, Lai, F. Anthony

“…Phospholipase C-zeta (PLCζ) is a strong candidate for the mammalian sperm-derived factor that triggers the Ca2+ oscillations required for egg activation at…”
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Defective Interaction of Cam with RyR2 Cam-Binding Pocket Might Contribute to Arrhythmogenic Cardiac Disease by Nomikos, Michail, Thanassoulas, Angelos, Vassilakopoulou, Vyronia, Calver, Brian L., Livaniou, Evangelia, Safieh-Garabedian, Bared, Toft, Egon, Nounesis, George, Lai, F. Anthony

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Human PLCζ exhibits superior fertilization potency over mouse PLCζ in triggering the Ca2+ oscillations required for mammalian oocyte activation by Nomikos, Michail, Theodoridou, Maria, Elgmati, Khalil, Parthimos, Dimitris, Calver, Brian L., Buntwal, Luke, Nounesis, George, Swann, Karl, Lai, F. Anthony

“…A sperm-specific phospholipase C-zeta (PLCζ) is believed to play an essential role in oocyte activation during mammalian fertilization. Sperm PLCζ has been…”
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Calmodulin Interacts and Regulates Enzyme Activity of the Mammalian Sperm Phospholipase C by Nomikos, Michail, Thanassoulas, Angelos, Calver, Brian L., Theodoridou, Maria, Buntwal, Luke, Sideratou, Zili, Nounesis, George, Lai, F. Anthony

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