Search Results - "Calvano, Steven E."

APOε4 is associated with enhanced in vivo innate immune responses in human subjects by Gale, Stephen C., MD, Gao, Li, MD, PhD, Mikacenic, Carmen, MD, Coyle, Susette M., RN, Rafaels, Nicholas, MS, Murray Dudenkov, Tanda, MHS, Madenspacher, Jennifer H., MS, Draper, David W., PhD, Ge, William, Aloor, Jim J., PhD, Azzam, Kathleen M., PhD, Lai, Lihua, PhD, Blackshear, Perry J., MD, DPhil, Calvano, Steven E., PhD, Barnes, Kathleen C., PhD, Lowry, Stephen F., MD, Corbett, Siobhan, MD, PhD, Wurfel, Mark M, Fessler, Michael B., MD

“…Background The genetic determinants of the human innate immune response are poorly understood. Apolipoprotein (Apo) E, a lipid-trafficking protein that affects…”
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Agent-based modeling of endotoxin-induced acute inflammatory response in human blood leukocytes by Dong, Xu, Foteinou, Panagiota T, Calvano, Steven E, Lowry, Stephen F, Androulakis, Ioannis P

“…Inflammation is a highly complex biological response evoked by many stimuli. A persistent challenge in modeling this dynamic process has been the (nonlinear)…”
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Computational identification of transcriptional regulators in human endotoxemia by Nguyen, Tung T, Foteinou, Panagiota T, Calvano, Steven E, Lowry, Stephen F, Androulakis, Ioannis P

“…One of the great challenges in the post-genomic era is to decipher the underlying principles governing the dynamics of biological responses. As modulating gene…”
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A dual negative regulation model of Toll-like receptor 4 signaling for endotoxin preconditioning in human endotoxemia by Yang, Qian, Calvano, Steven E., Lowry, Stephen F., Androulakis, Ioannis P.

“…► We explore models describing the outcome of repeated endotoxin administration. ► The response emerges as a natural consequence of tightly regulated signaling…”
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A genomic storm in critically injured humans by Xiao, Wenzhong, Mindrinos, Michael N, Seok, Junhee, Cuschieri, Joseph, Cuenca, Alex G, Gao, Hong, Hayden, Douglas L, Hennessy, Laura, Moore, Ernest E, Minei, Joseph P, Bankey, Paul E, Johnson, Jeffrey L, Sperry, Jason, Nathens, Avery B, Billiar, Timothy R, West, Michael A, Brownstein, Bernard H, Mason, Philip H, Baker, Henry V, Finnerty, Celeste C, Jeschke, Marc G, López, M Cecilia, Klein, Matthew B, Gamelli, Richard L, Gibran, Nicole S, Arnoldo, Brett, Xu, Weihong, Zhang, Yuping, Calvano, Steven E, McDonald-Smith, Grace P, Schoenfeld, David A, Storey, John D, Cobb, J Perren, Warren, H Shaw, Moldawer, Lyle L, Herndon, David N, Lowry, Stephen F, Maier, Ronald V, Davis, Ronald W, Tompkins, Ronald G

“…Human survival from injury requires an appropriate inflammatory and immune response. We describe the circulating leukocyte transcriptome after severe trauma…”
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Mathematical modeling of light-mediated HPA axis activity and downstream implications on the entrainment of peripheral clock genes by Mavroudis, Panteleimon D, Corbett, Siobhan A, Calvano, Steven E, Androulakis, Ioannis P

“…In this work we propose a semimechanistic model that describes the photic signal transduction to the hypothalamic-pituitary-adrenal (HPA) axis that ultimately…”
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Circadian characteristics of permissive and suppressive effects of cortisol and their role in homeostasis and the acute inflammatory response by Mavroudis, Panteleimon D., Corbett, Siobhan A., Calvano, Steven E., Androulakis, Ioannis P.

“…In this work we explore a semi-mechanistic model that considers cortisol's permissive and suppressive effects through the regulation of cytokine receptors and…”
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Human transcriptome array for high-throughput clinical studies by Xu, Weihong, Seok, Junhee, Mindrinos, Michael N, Schweitzer, Anthony C, Jiang, Hui, Wilhelmy, Julie, Clark, Tyson A, Kapur, Karen, Xing, Yi, Faham, Malek, Storey, John D, Moldawer, Lyle L, Maier, Ronald V, Tompkins, Ronald G, Wong, Wing Hung, Davis, Ronald W, Xiao, Wenzhong

“…A 6.9 million-feature oligonucleotide array of the human transcriptome [Glue Grant human transcriptome (GG-H array)] has been developed for high-throughput and…”
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Modeling autonomic regulation of cardiac function and heart rate variability in human endotoxemia by Scheff, Jeremy D, Mavroudis, Panteleimon D, Calvano, Steven E, Lowry, Stephen F, Androulakis, Ioannis P

“…Heart rate variability (HRV), the quantification of beat-to-beat variability, has been studied as a potential prognostic marker in inflammatory diseases such…”
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Pulsatile Glucocorticoid Secretion: Origins and Downstream Effects by Scheff, Jeremy D., Kosmides, Alyssa K., Calvano, Steven E., Lowry, Stephen F., Androulakis, Ioannis P.

“…Glucocorticoids are steroid hormones which, among other functions, exert an antiinflammatory effect. Endogenous glucocorticoids are normally secreted by the…”
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Decreased communication leads to diminished physiologic variability in a multiscale model of inflammation by Scheff, Jeremy D, Calvano, Steven E, Lowry, Stephen F, Androulakis, Ioannis P

“…Sample entropy estimates the probability that subseries of data that match within a defined tolerance will also match at the next time point; this allows the…”
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Lymphomas in dogs. A morphologic, immunologic, and clinical study by Greenlee, P G, Filippa, D A, Quimby, F W, Patnaik, A K, Calvano, S E, Matus, R E, Kimmel, M, Hurvitz, A I, Lieberman, P H

“…One hundred seventy-six canine lymphomas were classified morphologically using four of the major human lymphoma classification schemes (Rappaport,…”
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Clinical microfluidics for neutrophil genomics and proteomics by Kotz, Kenneth T, Toner, Mehmet, Xiao, Wenzong, Miller-Graziano, Carol, Qian, Wei-Jun, Russom, Aman, Warner, Elizabeth A, Moldawer, Lyle L, De, Asit, Bankey, Paul E, Petritis, Brianne O, Camp, David G, Rosenbach, Alan E, Goverman, Jeremy, Fagan, Shawn P, Brownstein, Bernard H, Irimia, Daniel, Xu, Weihong, Wilhelmy, Julie, Mindrinos, Michael N, Smith, Richard D, Davis, Ronald W, Tompkins, Ronald G

“…Standard methods of neutrophil isolation require skilled personnel, are time consuming and use large blood volumes. Kotz and his colleagues have developed a…”
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Mathematical modeling of lightmediated HPA axis activity and downstream implications on the entrainment of peripheral clock genes by Mavroudis, Panteleimon D, Corbett, Siobhan A, Calvano, Steven E, Androulakis, Ioannis P

“…In this work we propose a semimechanistic model that describes the photic signal transduction to the hypothalamicpituitaryadrenal (HPA) axis that ultimately…”
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A physiological model for autonomic heart rate regulation in human endotoxemia by Foteinou, Panagiota T, Calvano, Steve E, Lowry, Stephen F, Androulakis, Ioannis P

“…The systemic inflammatory response syndrome often accompanies critical illnesses and can be an important cause of morbidity and mortality. Marked abnormalities…”
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Pulsatile Glucocorticoid Secretion: Origins and Downstream Effects: Special Issue on Multiscale Modeling and Analysis in Computational Biology and Medicine-Part 2 by SCHEFF, Jeremy D, KOSMIDES, Alyssa K, CALVANO, Steven E, LOWRY, Stephen F, ANDROULAKIS, Ioannis P

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Comparative proteome analyses of human plasma following in vivo lipopolysaccharide administration using multidimensional separations coupled with tandem mass spectrometry by Qian, Wei-Jun, Jacobs, Jon M., Camp II, David G., Monroe, Matthew E., Moore, Ronald J., Gritsenko, Marina A., Calvano, Steve E., Lowry, Stephen F., Xiao, Wenzhong, Moldawer, Lyle L., Davis, Ronald W., Tompkins, Ronald G., Smith, Richard D.

“…There is significant interest in characterization of the human plasma proteome due to its potential for providing biomarkers applicable to clinical diagnosis…”
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APOε 4 is associated with enhanced in vivo innate immune responses in humans by Gale, Stephen C., Gao, Li, Mikacenic, Carmen, Coyle, Susette M., Rafaels, Nicholas, Murray, Tanda, Madenspacher, Jennifer H., Draper, David W., Ge, William, Aloor, Jim J., Azzam, Kathleen M., Lai, Lihua, Blackshear, Perry J., Calvano, Steven E., Barnes, Kathleen C., Lowry, Stephen F., Corbett, Siobhan, Wurfel, Mark M., Fessler, Michael B.

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Trauma-associated human neutrophil alterations revealed by comparative proteomics profiling by Zhou, Jian-Ying, Krovvidi, Ravi K., Gao, Yuqian, Gao, Hong, Petritis, Brianne O., De, Asit K., Miller-Graziano, Carol L., Bankey, Paul E., Petyuk, Vladislav A., Nicora, Carrie D., Clauss, Therese R., Moore, Ronald J., Shi, Tujin, Brown, Joseph N., Kaushal, Amit, Xiao, Wenzhong, Davis, Ronald W., Maier, Ronald V., Tompkins, Ronald G., Qian, Wei-Jun, Camp II, David G., Smith, Richard D.

“…Purpose Polymorphonuclear neutrophils (PMNs) play an important role in mediating the innate immune response after severe traumatic injury; however, the…”
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Comparison of longitudinal leukocyte gene expression after burn injury or trauma-hemorrhage in mice by Lederer, James A, Brownstein, Bernard H, Lopez, M. Cecilia, MacMillan, Sandra, Delisle, Adam J, MacConmara, Malcolm P, Choudhry, Mashkoor A, Xiao, Wenzhong, Lekousi, Steven, Cobb, J. Perren, Baker, Henry V, Mannick, John A, Chaudry, Irshad H, Inflammation and Host Response to Injury Collaborative Research Program Participants

“…1 Department of Surgery, Brigham and Women's Hospital/Harvard Medical School, Boston, Massachusetts 2 Department of Surgery, Washington University School of…”
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