Evaluation of Bioactive Compounds, Antioxidant Capacity, and Anti-Inflammatory Effects of Lipophilic and Hydrophilic Extracts of the Pericarp of Passiflora tripartita var. mollissima at Two Stages of Ripening

Chronic disease inflammation requires safe complementary treatments. The pericarp of var. (PTM) contains potential anti-inflammatory metabolites. This study aimed to evaluate the bioactive components, antioxidant capacity, and anti-inflammatory effects of PTM extracts at two ripening stages. The bio...

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Published in:	Molecules (Basel, Switzerland) Vol. 29; no. 20; p. 4964
Main Authors:	Justil-Guerrero, Hugo Jesús, Arroyo-Acevedo, Jorge Luis, Rojas-Armas, Juan Pedro, García-Bustamante, Carlos Orlando, Palomino-Pacheco, Miriam, Almonacid-Román, Robert Dante, Calva Torres, James Willan
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 21-10-2024 MDPI
Subjects:	Analysis Animals anti-inflammatory Anti-Inflammatory Agents - chemistry Anti-Inflammatory Agents - pharmacology antioxidant Antioxidants Antioxidants - chemistry Antioxidants - pharmacology Carrageenan Carrageenin Chronic diseases Chronic illnesses Cytokines - metabolism Drug dosages Edema Edema - chemically induced Edema - drug therapy Flavonoids Flavonoids - analysis Flavonoids - chemistry Flavonoids - pharmacology Fruit - chemistry Hydrophobic and Hydrophilic Interactions Indomethacin Inflammation inflammatory cytokines Isoflavones Leukocytes Male Metabolites Oxidative stress Oxidative Stress - drug effects Passiflora - chemistry Passiflora tripartita var. mollissima Phenols - analysis Phenols - chemistry Phenols - pharmacology Phytochemicals Phytochemicals - chemistry Phytochemicals - pharmacology Plant Extracts - chemistry Plant Extracts - pharmacology Rats anti-inflammatory antioxidant inflammatory cytokines Passiflora tripartita var. mollissima oxidative stress
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Summary:	Chronic disease inflammation requires safe complementary treatments. The pericarp of var. (PTM) contains potential anti-inflammatory metabolites. This study aimed to evaluate the bioactive components, antioxidant capacity, and anti-inflammatory effects of PTM extracts at two ripening stages. The bioactive compounds in the hydrophilic and lipophilic extracts of mature and green pericarps were identified by GC-MS and UV-VIS, while the antioxidant capacity was measured by free radical reduction. Anti-inflammatory effects were tested using a rat paw edema model with carrageenan-induced edema, indomethacin, or PTM extracts (100, 250, and 500 mg/kg). The effect of mature hydrophilic extract was further evaluated in an air pouch model, where rats received the placebo, carrageenan, indomethacin, or the extract (500 and 1000 mg/kg). Leukocytes, cytokines, and markers of oxidative stress were evaluated. The results showed the presence of organic compounds, total phenols, and flavonoids. The mature hydrophilic extract exhibited the highest antioxidant activity. At 500 mg/kg, it reduced edema, leukocyte migration, and levels of IL-1β, IL-6, and TNF-α while managing oxidative stress and preventing histological damage. In conclusion, PTM contains bioactive compounds with potential pharmacological properties. The hydrophilic extract of the mature pericarp, at a dose of 500 mg/kg, exhibits an enhanced antioxidant and anti-inflammatory effect.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1420-3049 1420-3049
DOI:	10.3390/molecules29204964