Search Results - "Callow, Marinella"

Ubiquitin ligase RNF146 regulates tankyrase and Axin to promote Wnt signaling by Callow, Marinella G, Tran, Hoanh, Phu, Lilian, Lau, Ted, Lee, James, Sandoval, Wendy N, Liu, Peter S, Bheddah, Sheila, Tao, Janet, Lill, Jennie R, Hongo, Jo-Anne, Davis, David, Kirkpatrick, Donald S, Polakis, Paul, Costa, Mike

“…Canonical Wnt signaling is controlled intracellularly by the level of β-catenin protein, which is dependent on Axin scaffolding of a complex that…”
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A saturation mutagenesis screen uncovers resistant and sensitizing secondary KRAS mutations to clinical KRASG12C inhibitors by Feng, Siyu, Callow, Marinella G, tin, Jean-Philippe, Khan, Zia, Bray, David, Costa, Mike, Shi, Zhen, Wang, Weiru, Evangelista, Marie

“…Mutant-specific inhibitors of KRASG12C, such as AMG510 (sotorasib) and MRTX849 (adagrasib), offer the unprecedented opportunity to inhibit KRAS, the most…”
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A Novel Tankyrase Small-Molecule Inhibitor Suppresses APC Mutation―Driven Colorectal Tumor Growth by LAU, Ted, CHAN, Emily, MACHON, Ondrej, KORINEK, Vladimir, CHOO, Edna, DIAZ, Dolores, MERCHANT, Mark, POLAKIS, Paul, HOLSWORTH, Daniel D, KRAUSS, Stefan, COSTA, Mike, CALLOW, Marinella, WAALER, Jo, BOGGS, Jason, BLAKE, Robert A, MAGNUSON, Steven, SAMBRONE, Amy, SCHUTTEN, Melissa, FIRESTEIN, Ron

“…Most colorectal cancers (CRC) are initiated by mutations of APC, leading to increased β-catenin-mediated signaling. However, continued requirement of…”
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A saturation mutagenesis screen uncovers resistant and sensitizing secondary KRAS mutations to clinical KRAS G12C inhibitors by Feng, Siyu, Callow, Marinella G, Fortin, Jean-Philippe, Khan, Zia, Bray, David, Costa, Mike, Shi, Zhen, Wang, Weiru, Evangelista, Marie

“…Mutant-specific inhibitors of KRASG12C, such as AMG510 (sotorasib) and MRTX849 (adagrasib), offer the unprecedented opportunity to inhibit KRAS, the most…”
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CRISPR whole-genome screening identifies new necroptosis regulators and RIPK1 alternative splicing by Callow, Marinella G., Watanabe, Colin, Wickliffe, Katherine E., Bainer, Russell, Kummerfield, Sarah, Weng, Julie, Cuellar, Trinna, Janakiraman, Vasantharajan, Chen, Honglin, Chih, Ben, Liang, Yuxin, Haley, Benjamin, Newton, Kim, Costa, Michael R.

“…The necroptotic cell death pathway is a key component of human pathogen defense that can become aberrantly derepressed during tissue homeostasis to contribute…”
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PAK4 mediates morphological changes through the regulation of GEF-H1 by Callow, Marinella G, Zozulya, Sergey, Gishizky, Mikhail L, Jallal, Bahija, Smeal, Tod

“…Precise spatial and temporal regulation of Rho GTPases is required in controlling F-actin-based changes in cell morphology. The molecular mechanisms through…”
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Requirement for PAK4 in the Anchorage-independent Growth of Human Cancer Cell Lines by Callow, Marinella G., Clairvoyant, Felix, Zhu, Shirley, Schryver, Brian, Whyte, David B., Bischoff, James R., Jallal, Bahija, Smeal, Tod

“…p21-activated protein kinase (PAK) serine/threonine kinases are important effectors of Rho family GTPases and have been implicated in the regulation of cell…”
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Liposomal packaging generates Wnt protein with in vivo biological activity by Morrell, Nathan T, Leucht, Philipp, Zhao, Ludan, Kim, Jae-Beom, ten Berge, Derk, Ponnusamy, Karthik, Carre, A Lyonel, Dudek, Henryk, Zachlederova, Marie, McElhaney, Michael, Brunton, Shirley, Gunzner, Janet, Callow, Marinella, Polakis, Paul, Costa, Mike, Zhang, Xiaoyan M, Helms, Jill A, Nusse, Roel

“…Wnt signals exercise strong cell-biological and regenerative effects of considerable therapeutic value. There are, however, no specific Wnt agonists and no…”
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MRK, a Mixed Lineage Kinase-related Molecule That Plays a Role in γ-Radiation-induced Cell Cycle Arrest by Gross, Eleanore A., Callow, Marinella G., Waldbaum, Linda, Thomas, Suzanne, Ruggieri, Rosamaria

“…Mitogen-activated protein (MAP) kinase pathways are three-kinase modules that mediate diverse cellular processes and have been highly conserved among…”
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Abstract A46: A pan-cancer RAS mutant library elucidates the transformation potential of RAS variants by Moore, Amanda R., Fortin, Jean-Philippe, Costa, Michael, Callow, Marinella, Haley, Benjamin, Manning, Gerard, Sokol, Ethan S., Malek, Shiva

“…RAS mutations are highly prevalent in tumors, especially those of the lung, colon, skin and pancreas. The tissues in which these tumors arise are enriched for…”
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Systematic perturbation screens identify regulators of inflammatory macrophage states and a role for TNF mRNA m6A modification by Haag, Simone M., Xie, Shiqi, Eidenschenk, Celine, Fortin, Jean-Philippe, Callow, Marinella, Costa, Mike, Lun, Aaron, Cox, Chris, Wu, Sunny Z., Pradhan, Rachana N., Lock, Jaclyn, Kuhn, Julia A., Holokai, Loryn, Thai, Minh, Freund, Emily, Nissenbaum, Ariane, Keir, Mary, Bohlen, Christopher J., Martin, Scott, Geiger-Schuller, Kathryn, Hejase, Hussein A., Yaspan, Brian L., Melo Carlos, Sandra, Turley, Shannon J., Murthy, Aditya

“…Macrophages exhibit remarkable functional plasticity, a requirement for their central role in tissue homeostasis. During chronic inflammation, macrophages…”
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Accelerated drug-resistant variant discovery with an enhanced, scalable mutagenic base editor platform by Dorighi, Kristel M., Zhu, Anqi, Fortin, Jean-Philippe, Hung-Hao Lo, Jerry, Sudhamsu, Jawahar, Wendorff, Timothy J., Durinck, Steffen, Callow, Marinella, Foster, Scott A., Haley, Benjamin

“…Personalized cancer therapeutics bring directed treatment options to patients based on their tumor’s genetic signature. Unfortunately, tumor genomes are…”
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Abstract 398: Functional coding and noncoding drivers of EMT-mediated acquired drug resistance by Bainer, Russell O., Wilson, Catherine, Callow, Marinella, Feng, Siyu, Costa, Michael, Watanabe, Colin, Mayba, Oleg, Lin, Eva, Martin, Scott, Yauch, Bob, Bourgon, Richard, Klijn, Christiaan

“…In response to diverse stimuli, tumor cells can undergo a process resembling the epithelial-mesenchymal transition (EMT) observed during development. During…”
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Private specificities can dominate the humoral response to self-antigens in patients with cryptogenic fibrosing alveolitis by Robinson, C, Callow, M, Stevenson, S, Robinson, B W, Lake, R A

“…The pathogenetic mechanisms that underlie the interstitial lung disease cryptogenic fibrosing alveolitis (CFA) may involve an immunological reaction to…”
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IQGAP1, a calmodulin‐binding protein with a rasGAP‐related domain, is a potential effector for cdc42Hs by Hart, M. J., Callow, M. G., Souza, B., Polakis, P.

“…Proteins that associate with the GTP‐bound forms of the Ras superfamily of proteins are potential effector targets for these molecular switches. A 195 kDa…”
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Serologic Responses in Patients with Malignant Mesothelioma . Evidence for Both Public and Private Specificities by Robinson, Cleo, Callow, Marinella, Stevenson, Sandra, Scott, Bernadette, Robinson, Bruce W. S, Lake, Richard A

“…Malignant mesothelioma (MM) is a pulmonary malignancy that appears to be immunogenic based on a large number of studies in both animals and humans. This notion…”
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MRK, a Mixed Lineage Kinase-related Molecule That Plays a Role in γ-Radiation-induced Cell Cycle Arrest by Eleanore A. Gross, Marinella G. Callow, Linda Waldbaum, Suzanne Thomas, Rosamaria Ruggieri

“…Mitogen-activated protein (MAP) kinase pathways are three-kinase modules that mediate diverse cellular processes and have been highly conserved among…”
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A High-Molecular-Weight Outer Membrane Protein That Is a Potential Target for ProtectiveImmunity to Type band Untypeable Haemophilus influenzae by Thomas, Wayne R., Flack, Felicity S., Callow, Marinella G., Chua, Kaw-Van

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A High-Molecular-Weight Outer Membrane Protein That Is a Potential Target for Protective Immunity to Type b and Untypeable Haemophilus influenzae by Thomas, Wayne R., Flack, Felicity S., Callow, Marinella G., Chua, Kaw-Yan

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