Search Results - "Callaway, Evelyn S."

Short Chain Fatty Acids Enhance Aryl Hydrocarbon (Ah) Responsiveness in Mouse Colonocytes and Caco-2 Human Colon Cancer Cells by Jin, Un-Ho, Cheng, Yating, Park, Hyejin, Davidson, Laurie A., Callaway, Evelyn S., Chapkin, Robert S., Jayaraman, Arul, Asante, Andrew, Allred, Clinton, Weaver, Evelyn A., Safe, Stephen

“…Aryl hydrocarbon receptor (AhR) ligands are important for gastrointestinal health and play a role in gut inflammation and the induction of T regulatory cells,…”
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A bioassay to measure energy metabolism in mouse colonic crypts, organoids, and sorted stem cells by Fan, Yang-Yi, Davidson, Laurie A, Callaway, Evelyn S, Wright, Gus A, Safe, Stephen, Chapkin, Robert S

“…Evidence suggests that targeting cancer cell energy metabolism might be an effective therapeutic approach for selective ablation of malignancies. Using a…”
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Involvement of Intestinal Epithelium Aryl Hydrocarbon Receptor Expression and 3, 3'-Diindolylmethane in Colonic Tertiary Lymphoid Tissue Formation by Garcia-Villatoro, Erika L, Bomstein, Zachary S, Allred, Kimberly F, Callaway, Evelyn S, Safe, Stephen, Chapkin, Robert S, Jayaraman, Arul, Allred, Clinton D

“…Tertiary lymphoid tissues (TLTs) are adaptive immune structures that develop during chronic inflammation and may worsen or lessen disease outcomes in a…”
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Targeted Deletion of p53 in Lgr5-Expressing Intestinal Stem Cells Promotes Colon Tumorigenesis in a Preclinical Model of Colitis-Associated Cancer by Davidson, Laurie A, Callaway, Evelyn S, Kim, Eunjoo, Weeks, Brad R, Fan, Yang-Yi, Allred, Clinton D, Chapkin, Robert S

“…p53 has been shown to mediate cancer stem-like cell function by suppressing pluripotency and cellular dedifferentiation. However, there have been no studies to…”
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Chemopreventive n-3 polyunsaturated fatty acids reprogram genetic signatures during colon cancer initiation and progression in the rat by DAVIDSON, Laurie A, NGUYEN, Danh V, CHAPKIN, Robert S, HOKANSON, Regina M, CALLAWAY, Evelyn S, ISETT, Robert B, TURNER, Nancy D, DOUGHERTY, Edward R, NAISYIN WANG, LUPTON, Joanne R, CARROLL, Raymond J

“…The mechanisms by which n-3 polyunsaturated fatty acids (PUFAs) decrease colon tumor formation have not been fully elucidated. Examination of genes up- or…”
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Effects of high-fat diet and intestinal aryl hydrocarbon receptor deletion on colon carcinogenesis by Garcia-Villatoro, Erika L, DeLuca, Jennifer A A, Callaway, Evelyn S, Allred, Kimberly F, Davidson, Laurie A, Hensel, Martha E, Menon, Rani, Ivanov, Ivan, Safe, Stephen H, Jayaraman, Arul, Chapkin, Robert S, Allred, Clinton D

“…Consumption of a high-fat diet has been associated with an increased risk of developing colorectal cancer (CRC). However, the effects of the interaction…”
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Data describing the effects of dietary bioactive agents on colonic stem cell microRNA and mRNA expression by Shah, Manasvi S., Kim, Eunjoo, Davidson, Laurie A., Knight, Jason M., Zoh, Roger S., Goldsby, Jennifer S., Callaway, Evelyn S., Zhou, Beyian, Ivanov, Ivan, Chapkin, Robert S.

“…With the identification of Lgr5 as a definitive marker for intestinal stem cells, we used the highly novel, recently described, Lgr5-EGFP-IRES-cre ERT2knock in…”
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Alteration of colonic stem cell gene signatures during the regenerative response to injury by Davidson, Laurie A., Goldsby, Jennifer S., Callaway, Evelyn S., Shah, Manasvi S., Barker, Nick, Chapkin, Robert S.

“…Since aberrant wound healing and chronic inflammation can promote malignant transformation, we determined whether dietary bioactive fish oil (FO)-derived n−3…”
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Inhibitory effects of omega-3 fatty acids on injury-induced epidermal growth factor receptor transactivation contribute to delayed wound healing by Turk, Harmony F, Monk, Jennifer M, Fan, Yang-Yi, Callaway, Evelyn S, Weeks, Brad, Chapkin, Robert S

“…Epidermal growth factor receptor (EGFR)-mediated signaling is required for optimal intestinal wound healing. Since n-3 polyunsaturated fatty acids (PUFA),…”
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Differential effects of 2- and 3-series E-prostaglandins on in vitro expansion of Lgr5+ colonic stem cells by Fan, Yang-Yi, Davidson, Laurie A, Callaway, Evelyn S, Goldsby, Jennifer S, Chapkin, Robert S

“…Arachidonic acid (20:4(Δ5,8,11,14), AA)-derived prostaglandin E2 (PGE2) promotes colon cancer development. In contrast, chemoprotective n-3 polyunsaturated…”
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Rapidly cycling Lgr5+ stem cells are exquisitely sensitive to extrinsic dietary factors that modulate colon cancer risk by Kim, Eunjoo, Davidson, Laurie A, Zoh, Roger S, Hensel, Martha E, Salinas, Michael L, Patil, Bhimanagouda S, Jayaprakasha, Guddadarangavvanahally K, Callaway, Evelyn S, Allred, Clinton D, Turner, Nancy D, Weeks, Brad R, Chapkin, Robert S

“…The majority of colon tumors are driven by aberrant Wnt signaling in intestinal stem cells, which mediates an efficient route toward initiating intestinal…”
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Establishment of a multicomponent dietary bioactive human equivalent dose to delete damaged Lgr5+ stem cells using a mouse colon tumor initiation model by Kim, Eunjoo, Wright, Gus A, Zoh, Roger S, Patil, Bhimanagouda S, Jayaprakasha, Guddadarangavvanahally K, Callaway, Evelyn S, Ivanov, Ivan, Turner, Nancy D, Chapkin, Robert S

“…Multicomponent therapy has gained interest for its potential to synergize and subsequently lower the effective dose of each constituent required to reduce…”
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Homeostatic responses of colonic LGR5+ stem cells following acute in vivo exposure to a genotoxic carcinogen by Kim, Eunjoo, Davidson, Laurie A, Zoh, Roger S, Hensel, Martha E, Patil, Bhimanagouda S, Jayaprakasha, Guddadarangavvanahally K, Callaway, Evelyn S, Allred, Clinton D, Turner, Nancy D, Weeks, Brad R, Chapkin, Robert S

“…Perturbations in DNA damage, DNA repair, apoptosis and cell proliferation in the base of the crypt where stem cells reside are associated with colorectal…”
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Comparative effects of diet and carcinogen on microRNA expression in the stem cell niche of the mouse colonic crypt by Shah, Manasvi S., Kim, Eunjoo, Davidson, Laurie A., Knight, Jason M., Zoh, Roger S., Goldsby, Jennifer S., Callaway, Evelyn S., Zhou, Beyian, Ivanov, Ivan, Chapkin, Robert S.

“…There is mounting evidence that noncoding microRNAs (miRNA) are modulated by select chemoprotective dietary agents. For example, recently we demonstrated that…”
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Dietary fish oil and curcumin combine to modulate colonic cytokinetics and gene expression in dextran sodium sulphate-treated mice by Jia, Qian, Ivanov, Ivan, Zlatev, Zlatomir Z., Alaniz, Robert C., Weeks, Brad R., Callaway, Evelyn S., Goldsby, Jennifer S., Davidson, Laurie A., Fan, Yang-Yi, Zhou, Lan, Lupton, Joanne R., McMurray, David N., Chapkin, Robert S.

“…Both fish oil (FO) and curcumin have potential as anti-tumour and anti-inflammatory agents. To further explore their combined effects on dextran sodium…”
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n‐3 PUFA Alter caveolae lipid composition and resident protein localization in mouse colon by Ma, David W.L., Seo, Jeongmin, Davidson, Laurie A., Callaway, Evelyn S., Fan, Yang-Yi, Lupton, Joanne R., Chapkin, Robert S.

“…ABSTRACT Caveolae, by virtue of their unique lipid environment, serve as signaling platforms that regulate cellular events. Perturbations in caveolae lipid…”
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Synergy between docosahexaenoic acid and butyrate elicits p53-independent apoptosis via mitochondrial Ca(2+) accumulation in colonocytes by Kolar, Satya Sree N, Barhoumi, Rola, Callaway, Evelyn S, Fan, Yang-Yi, Wang, Naisyin, Lupton, Joanne R, Chapkin, Robert S

“…Butyrate, a short-chain fatty acid fiber fermentation product, induces colonocyte apoptosis in part via a Fas-mediated (extrinsic) pathway. In previous…”
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Dietary fish oil promotes colonic apoptosis and mitochondrial proton leak in oxidatively stressed mice by Fan, Yang-Yi, Ran, Qitao, Toyokuni, Shinya, Okazaki, Yasumasa, Callaway, Evelyn S, Lupton, Joanne R, Chapkin, Robert S

“…An alteration of mitochondrial function can result in disruption of redox homeostasis and is associated with abnormal cancer cell growth. Manganese superoxide…”
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Imaging inflammation in mouse colon using a rapid stage-scanning confocal fluorescence microscope by Saldua, Meagan A, Olsovsky, Cory A, Callaway, Evelyn S, Chapkin, Robert S, Maitland, Kristen C

“…Large area confocal microscopy may provide fast, high-resolution image acquisition for evaluation of tissue in pre-clinical studies with reduced tissue…”
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Use of a novel genetic mouse model to investigate the role of folate in colitis-associated colon cancer by Chapkin, Robert S., Kamen, Barton A., Callaway, Evelyn S., Davidson, Laurie A., George, Nysia I., Wang, Naisyin, Lupton, Joanne R., Finnell, Richard H.

“…Inflammatory bowel disease (IBD) patients are at high risk for developing folate deficiency and colon cancer. Since it is difficult to study the subtle global…”
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