Search Results - "Callaghan, S. M."

c-Jun Mediates Axotomy-Induced Dopamine Neuron Death in vivo by Crocker, S. J., Lamba, W. R., Smith, P. D., Callaghan, S. M., Slack, R. S., Anisman, H., Park, D. S.

“…Expression of the transcription factor c-Jun is induced in neurons of the central nervous system (CNS) in response to injury. Mechanical transection of the…”
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Helper-dependent adenovirus vectors : Their use as a gene delivery system to neurons by CREGAN, S. P, MACLAURIN, J, GENDRON, T. F, CALLAGHAN, S. M, PARK, D. S, PARKS, R. J, GRAHAM, F. L, MORLEY, P, SLACK, R. S

“…Recombinant adenovirus vectors have provided a major advance in gene delivery systems for post-mitotic neurons. However, the use of these first generation…”
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Apoptosis-Inducing Factor Is Involved in the Regulation of Caspase-Independent Neuronal Cell Death by Cregan, Sean P., Fortin, Andre, MacLaurin, Jason G., Callaghan, Steven M., Cecconi, Francesco, Yu, Seong-Woon, Dawson, Ted M., Dawson, Valina L., Park, David S., Kroemer, Guido, Slack, Ruth S.

“…Caspase-independent death mechanisms have been shown to execute apoptosis in many types of neuronal injury. P53 has been identified as a key regulator of…”
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Inhibition of Calpains Prevents Neuronal and Behavioral Deficits in an MPTP Mouse Model of Parkinson's Disease by Crocker, Stephen J, Smith, Patrice D, Jackson-Lewis, Vernice, Lamba, Wiplore R, Hayley, Shawn P, Grimm, Erich, Callaghan, Steve M, Slack, Ruth S, Melloni, Edon, Przedborski, Serge, Robertson, George S, Anisman, Hymie, Merali, Zul, Park, David S

“…The molecular mechanisms mediating degeneration of midbrain dopamine neurons in Parkinson's disease (PD) are poorly understood. Here, we provide evidence to…”
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Nuclear Factor-κB Modulates the p53 Response in Neurons Exposed to DNA Damage by Aleyasin, Hossein, Cregan, Sean P., Iyirhiaro, Grace, O'Hare, Michael J., Callaghan, Steve M., Slack, Ruth S., Park, David S.

“…Previous studies have shown that DNA damage-evoked death of primary cortical neurons occurs in a p53 and cyclin-dependent kinase-dependent (CDK) manner. The…”
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The Proapoptotic Gene SIVA Is a Direct Transcriptional Target for the Tumor Suppressors p53 and E2F1 by Fortin, Andre, MacLaurin, Jason G, Arbour, Nicole, Cregan, Sean P, Kushwaha, Neena, Callaghan, Steven M, Park, David S, Albert, Paul R, Slack, Ruth S

“…The p53 tumor suppressor gene is believed to play an important role in neuronal cell death in acute neurological disease and in neurodegeneration. The p53…”
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The Rb-CDK4/6 Signaling Pathway Is Critical in Neural Precursor Cell Cycle Regulation by Ferguson, Kerry L., Callaghan, Steven M., O'Hare, Michael J., Park, David S., Slack, Ruth S.

“…The tumor suppressor, retinoblastoma (Rb), is involved in both terminal mitosis and neuronal differentiation. We hypothesized that activation of the Rb pathway…”
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Neural Precursor Cells Differentiating in the Absence of Rb Exhibit Delayed Terminal Mitosis and Deregulated E2F 1 and 3 Activity by Callaghan, Debbie A., Dong, Li, Callaghan, Steven M., Hou, Yang Xun, Dagnino, Lina, Slack, Ruth S.

“…The severe neurological deficit in embryos carrying null mutations for the retinoblastoma (Rb) gene suggests that Rb plays a crucial role in neurogenesis…”
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Differential Roles of Nuclear and Cytoplasmic Cyclin-Dependent Kinase 5 in Apoptotic and Excitotoxic Neuronal Death by O'Hare, Michael J, Kushwaha, Neena, Zhang, Yi, Aleyasin, Hossein, Callaghan, Steven M, Slack, Ruth S, Albert, Paul R, Vincent, Inez, Park, David S

“…Cyclin-dependent kinase 5 (cdk5) is a member of the cyclin-dependent kinase family whose activity is localized mainly to postmitotic neurons attributable to…”
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Apical Role for BRG1 in Cytokine-Induced Promoter Assembly by Zuyao Ni, Karaskov, Elizabeth, Yu, Tao, Callaghan, Steven M., Sandy Der, Park, David S., Zhaodong Xu, Samantha G. Pattenden, Bremner, Rod

“…IFN-γ induction of the CIITA (class II transactivator) promoter (pIV) requires Brahma-related gene 1 (BRG1), a chromatin-remodeling enzyme. However, the events…”
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p53 Activation Domain 1 Is Essential for PUMA Upregulation and p53-Mediated Neuronal Cell Death by Cregan, Sean P, Arbour, Nicole A, MacLaurin, Jason G, Callaghan, Steven M, Fortin, Andre, Cheung, Eric C. C, Guberman, Daniel S, Park, David S, Slack, Ruth S

“…The p53 tumor suppressor gene has been implicated in the regulation of apoptosis in a number of different neuronal death paradigms. Because of the importance…”
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Regulation of axotomy‐induced dopaminergic neuron death and c‐Jun phosphorylation by targeted inhibition of cdc42 or mixed lineage kinase by Crocker, Stephen J., Hayley, Shawn P., Smith, Patrice D., Mount, Matthew P., Lamba, Wiplove R., Callaghan, Steven M., Slack, Ruth S., Park, David S.

“…Mechanical transection of the nigrostriatal dopamine pathway at the medial forebrain bundle (MFB) results in the delayed degeneration of dopaminergic neurons…”
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