Search Results - "Call, Lee"

IMG/VR v3: an integrated ecological and evolutionary framework for interrogating genomes of uncultivated viruses by Roux, Simon, Páez-Espino, David, Chen, I-Min A, Palaniappan, Krishna, Ratner, Anna, Chu, Ken, Reddy, T B K, Nayfach, Stephen, Schulz, Frederik, Call, Lee, Neches, Russell Y, Woyke, Tanja, Ivanova, Natalia N, Eloe-Fadrosh, Emiley A, Kyrpides, Nikos C

“…Abstract Viruses are integral components of all ecosystems and microbiomes on Earth. Through pervasive infections of their cellular hosts, viruses can reshape…”
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Metagenomic compendium of 189,680 DNA viruses from the human gut microbiome by Nayfach, Stephen, Páez-Espino, David, Call, Lee, Low, Soo Jen, Sberro, Hila, Ivanova, Natalia N., Proal, Amy D., Fischbach, Michael A., Bhatt, Ami S., Hugenholtz, Philip, Kyrpides, Nikos C.

“…Bacteriophages have important roles in the ecology of the human gut microbiome but are under-represented in reference databases. To address this problem, we…”
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Parenteral lipids shape gut bile acid pools and microbiota profiles in the prevention of cholestasis in preterm pigs[S] by Call, Lee, Molina, Tiffany, Stoll, Barbara, Guthrie, Greg, Chacko, Shaji, Plat, Jogchum, Robinson, Jason, Lin, Sen, Vonderohe, Caitlin, Mohammad, Mahmoud, Kunichoff, Dennis, Cruz, Stephanie, Lau, Patricio, Premkumar, Muralidhar, Nielsen, Jon, Fang, Zhengfeng, Olutoye, Oluyinka, Thymann, Thomas, Britton, Robert, Sangild, Per, Burrin, Douglas

“…Multi-component lipid emulsions, rather than soy-oil emulsions, prevent cholestasis by an unknown mechanism. Here, we quantified liver function, bile acid…”
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Probiotics and Human Milk Differentially Influence the Gut Microbiome and NEC Incidence in Preterm Pigs by Melendez Hebib, Valeria, Taft, Diana H, Stoll, Barbara, Liu, Jinxin, Call, Lee, Guthrie, Gregory, Jensen, Nick, Hair, Amy B, Mills, David A, Burrin, Douglas G

“…Necrotizing enterocolitis (NEC) is the leading cause of death caused by gastrointestinal disease in preterm infants. Major risk factors include prematurity,…”
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A Small-Molecule Inhibitor of PIM Kinases as a Potential Treatment for Urothelial Carcinomas by Foulks, Jason M, Carpenter, Kent J, Luo, Bai, Xu, Yong, Senina, Anna, Nix, Rebecca, Chan, Ashley, Clifford, Adrianne, Wilkes, Marcus, Vollmer, David, Brenning, Benjamin, Merx, Shannon, Lai, Shuping, McCullar, Michael V, Ho, Koc-Kan, Albertson, Daniel J, Call, Lee T, Bearss, Jared J, Tripp, Sheryl, Liu, Ting, Stephens, Bret J, Mollard, Alexis, Warner, Steven L, Bearss, David J, Kanner, Steven B

“…Abstract The proto-oncogene proviral integration site for moloney murine leukemia virus (PIM) kinases (PIM-1, PIM-2, and PIM-3) are serine/threonine kinases…”
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Illuminating the Virosphere Through Global Metagenomics by Call, Lee, Nayfach, Stephen, Kyrpides, Nikos C

“…Viruses are the most abundant biological entity on Earth, infect cellular organisms from all domains of life, and are central players in the global biosphere…”
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Metabolomic signatures distinguish the impact of formula carbohydrates on disease outcome in a preterm piglet model of NEC by Call, Lee, Stoll, Barbara, Oosterloo, Berthe, Ajami, Nadim, Sheikh, Fariha, Wittke, Anja, Waworuntu, Rosaline, Berg, Brian, Petrosino, Joseph, Olutoye, Oluyinka, Burrin, Douglas

“…Major risk factors for necrotizing enterocolitis (NEC) include premature birth and formula feeding in the context of microbial colonization of the…”
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Design, Synthesis, and Biological Evaluation of a Series of Novel AXL Kinase Inhibitors by Mollard, Alexis, Warner, Steven L, Call, Lee T, Wade, Mark L, Bearss, Jared J, Verma, Anupam, Sharma, Sunil, Vankayalapati, Hariprasad, Bearss, David J

“…The receptor tyrosine kinase AXL has emerged in recent years as an potential oncology target due to its overexpression in several types of cancers coupled with…”
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IMG/VR v4: an expanded database of uncultivated virus genomes within a framework of extensive functional, taxonomic, and ecological metadata by Camargo, Antonio Pedro, Nayfach, Stephen, Chen, I-Min A, Palaniappan, Krishnaveni, Ratner, Anna, Chu, Ken, Ritter, Stephan J, Reddy, T B K, Mukherjee, Supratim, Schulz, Frederik, Call, Lee, Neches, Russell Y, Woyke, Tanja, Ivanova, Natalia N, Eloe-Fadrosh, Emiley A, Kyrpides, Nikos C, Roux, Simon

“…Viruses are widely recognized as critical members of all microbiomes. Metagenomics enables large-scale exploration of the global virosphere, progressively…”
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Unraveling the functional dark matter through global metagenomics by Pavlopoulos, Georgios A., Baltoumas, Fotis A., Liu, Sirui, Selvitopi, Oguz, Camargo, Antonio Pedro, Nayfach, Stephen, Azad, Ariful, Roux, Simon, Call, Lee, Ivanova, Natalia N., Chen, I. Min, Paez-Espino, David, Karatzas, Evangelos, Iliopoulos, Ioannis, Konstantinidis, Konstantinos, Tiedje, James M., Pett-Ridge, Jennifer, Baker, David, Visel, Axel, Ouzounis, Christos A., Ovchinnikov, Sergey, Buluç, Aydin, Kyrpides, Nikos C.

“…Metagenomes encode an enormous diversity of proteins, reflecting a multiplicity of functions and activities 1 , 2 . Exploration of this vast sequence space has…”
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IMG/PR: a database of plasmids from genomes and metagenomes with rich annotations and metadata by Camargo, Antonio Pedro, Call, Lee, Roux, Simon, Nayfach, Stephen, Huntemann, Marcel, Palaniappan, Krishnaveni, Ratner, Anna, Chu, Ken, Mukherjeep, Supratim, Reddy, T B K, Chen, I-Min A, Ivanova, Natalia N, Eloe-Fadrosh, Emiley A, Woyke, Tanja, Baltrus, David A, Castañeda-Barba, Salvador, de la Cruz, Fernando, Funnell, Barbara E, Hall, James P J, Mukhopadhyay, Aindrila, Rocha, Eduardo P C, Stalder, Thibault, Top, Eva, Kyrpides, Nikos C

“…Abstract Plasmids are mobile genetic elements found in many clades of Archaea and Bacteria. They drive horizontal gene transfer, impacting ecological and…”
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Fragment-based design, synthesis, biological evaluation, and SAR of 1H-benzo[d]imidazol-2-yl)-1H-indazol derivatives as potent PDK1 inhibitors by Chen, Ting, Sorna, Venkataswamy, Choi, Susie, Call, Lee, Bearss, Jared, Carpenter, Kent, Warner, Steven L., Sharma, Sunil, Bearss, David J., Vankayalapati, Hariprasad

“…[Display omitted] In this work, we describe the use of the rule of 3 fragment-based strategies from biochemical screening data of 1100 in-house, small, low…”
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New generation lipid emulsions increase brain DHA and improve body composition, but not short-term neurodevelopment in parenterally-fed preterm piglets by Molina, Tiffany L., Stoll, Barbara, Mohammad, Mahmoud, Mohila, Carrie A., Call, Lee, Cui, Liwei, Guthrie, Gregory, Kunichoff, Dennis, Lin, Sen, Welch-Jernigan, Rebecca, Nielsen, Jon, Premkumar, Muralidhar, Robinson, Jason, Smith, Victoria, Teets, Haley, Obelitz-Ryom, Karina, Hagan, Joseph, Cruz, Stephanie, Lau, Patricio, Puyau, Maurice, Shypailo, Roman, Manjarin, Rodrigo, Butte, Nancy, Fang, Zhengfeng, Olutoye, Oluyinka, Thymann, Thomas, Sangild, Per, Burrin, Douglas

“…•Modification of parenteral lipid profile alters cortical fatty acid (FA) profiles.•DHA and AA enriched parenteral lipid did not promote brain growth or…”
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Fragment-based design, synthesis, biological evaluation, and SAR of 1 H -benzo[ d ]imidazol-2-yl)-1 H -indazol derivatives as potent PDK1 inhibitors by Chen, Ting, Sorna, Venkataswamy, Choi, Susie, Call, Lee, Bearss, Jared, Carpenter, Kent, Warner, Steven L., Sharma, Sunil, Bearss, David J., Vankayalapati, Hariprasad

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Expanding the genomic encyclopedia of Actinobacteria with 824 isolate reference genomes by Seshadri, Rekha, Roux, Simon, Huber, Katharina J., Wu, Dongying, Yu, Sora, Udwary, Dan, Call, Lee, Nayfach, Stephen, Hahnke, Richard L., Pukall, Rüdiger, White, James R., Varghese, Neha J., Webb, Cody, Palaniappan, Krishnaveni, Reimer, Lorenz C., Sardà, Joaquim, Bertsch, Jonathon, Mukherjee, Supratim, Reddy, T.B.K., Hajek, Patrick P., Huntemann, Marcel, Chen, I-Min A., Spunde, Alex, Clum, Alicia, Shapiro, Nicole, Wu, Zong-Yen, Zhao, Zhiying, Zhou, Yuguang, Evtushenko, Lyudmila, Thijs, Sofie, Stevens, Vincent, Eloe-Fadrosh, Emiley A., Mouncey, Nigel J., Yoshikuni, Yasuo, Whitman, William B., Klenk, Hans-Peter, Woyke, Tanja, Göker, Markus, Kyrpides, Nikos C., Ivanova, Natalia N.

“…The phylum Actinobacteria includes important human pathogens like Mycobacterium tuberculosis and Corynebacterium diphtheriae and renowned producers of…”
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Abstract 4413: Mechanisms of sensitivity to treatment with the PDK1 inhibitors HCI-1680 and HCI-1708 by Walker, Brian, Venkataswamy, Sorna, Warner, Steven, Call, Lee, Vankayalapati, Hariprasad, Sharma, Sunil, Bearss, David J.

“…Abstract The phosphoinositide-dependent kinase-1 (PDK1) is a serine/threonine kinase that has been considered a promising potential oncology drug target…”
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Abstract 5543: Inhibition of the tyrosine kinase receptor Axl blocks cell invasion and promotes apoptosis in pancreatic cancer cells by Anderson, Malia, Ober, Alex, Mollard, Alexis, Call, Lee, Bearss, Jared J., Vankayalapati, Hariprasad, Sharma, Sunil, Warner, Steven, Bearss, David J.

“…Abstract Pancreatic cancer is virtually a uniformly lethal disease and a better understanding of the molecular basis of this malignancy is needed to discover…”
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Abstract 3391: Overexpression of Nek2 promotes bortezomib resistance in multiple myeloma cells by Flory, Jessica, Brog, Rachel, Meng, Ling Yao, Call, Lee, Vankayalapati, Hariprasad, Tricot, Guido, Zhan, Fenghuang, Bearss, David J.

“…Abstract Drug resistance is a major complication in cancer therapy but the molecular mechanisms driving both innate and acquired drug resistance still remain…”
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Abstract 1875: A novel series of metabolic activators of PKM2 alter oncogene-meditated changes in tumor cell metabolism by Bahr, Brigham L., Stevens, Jenny, Squire, Spencer, Moreno, Christopher, Call, Lee T., Stephens, Bret J., Mollard, Alexis, Warner, Steven L., Bearss, David J.

“…Abstract Rather than relying on oxidative phosphorylation for the generation of ATP, human tumor cells primarily utilize aerobic glycolysis to metabolize…”
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Abstract 1368: Fragment-based design, synthesis and biological evaluation of a series of novel PDK1 inhibitors by Sharma, Sunil, Venkataswamy, Sorna, Warner, Steven L., Call, Lee T., Bearss, David J., Vankayalapati, Hariprasad

“…Abstract The PDK1 is a monomeric serine/threonine kinase and a promising oncology target of significant current interest for drug development due to its…”
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