Search Results - "Cali, Gaetano"

Mitochondrial dysfunction in down syndrome: molecular mechanisms and therapeutic targets by Izzo, Antonella, Mollo, Nunzia, Nitti, Maria, Paladino, Simona, Calì, Gaetano, Genesio, Rita, Bonfiglio, Ferdinando, Cicatiello, Rita, Barbato, Maria, Sarnataro, Viviana, Conti, Anna, Nitsch, Lucio

“…Trisomy of chromosome 21 (TS21) is the most common autosomal aneuploidy compatible with postnatal survival with a prevalence of 1 in 700 newborns. Its…”
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Oleic acid promotes prostate cancer malignant phenotype via the G protein‐coupled receptor FFA1/GPR40 by Liotti, Antonietta, Cosimato, Vincenzo, Mirra, Paola, Calì, Gaetano, Conza, Domenico, Secondo, Agnese, Luongo, Gelsomina, Terracciano, Daniela, Formisano, Pietro, Beguinot, Francesco, Insabato, Luigi, Ulianich, Luca

“…Prostate cancer (PCa) is the most commonly diagnosed malignancy in men and the second leading cause of cancer‐related death in industrialized countries…”
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Hybrid Nanoparticle-Assisted Chemo-Photothermal Therapy and Photoacoustic Imaging in a Three-Dimensional Breast Cancer Cell Model by Carrese, Barbara, Cavallini, Chiara, Armanetti, Paolo, Silvestri, Brigida, Calì, Gaetano, Luciani, Giuseppina, Sanità, Gennaro, Menichetti, Luca, Lamberti, Annalisa

“…Bioinspired nanoparticles have recently been gaining attention as promising multifunctional nanoplatforms for therapeutic applications in cancer, including…”
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A Key Role of Leptin in the Control of Regulatory T Cell Proliferation by De Rosa, Veronica, Procaccini, Claudio, Calì, Gaetano, Pirozzi, Giuseppe, Fontana, Silvia, Zappacosta, Serafino, La Cava, Antonio, Matarese, Giuseppe

“…We report here that leptin can act as a negative signal for the proliferation of human naturally occurring Foxp3+CD4+CD25+ regulatory T (Treg) cells. Freshly…”
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The SGK1 inhibitor SI113 induces autophagy, apoptosis, and endoplasmic reticulum stress in endometrial cancer cells by Conza, Domenico, Mirra, Paola, Calì, Gaetano, Tortora, Teresa, Insabato, Luigi, Fiory, Francesca, Schenone, Silvia, Amato, Rosario, Beguinot, Francesco, Perrotti, Nicola, Ulianich, Luca

“…Endometrial cancer is often characterized by PI3K/AKT pathway deregulation. Recently it has been suggested that SGK1, a serine/threonine protein kinase that…”
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Colchicine inhibits the prothrombotic effects of oxLDL in human endothelial cells by Cimmino, Giovanni, Conte, Stefano, Morello, Andrea, Pellegrino, Grazia, Marra, Laura, Calì, Gaetano, Golino, Paolo, Cirillo, Plinio

“…Tissue Factor (TF) plays a pivotal role in coronary thrombosis. Oxidized low-density lipoproteins (oxLDL) are crucial in development of atherosclerosclerosis…”
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An Oscillatory Switch in mTOR Kinase Activity Sets Regulatory T Cell Responsiveness by Procaccini, Claudio, De Rosa, Veronica, Galgani, Mario, Abanni, Luisa, Calì, Gaetano, Porcellini, Antonio, Carbone, Fortunata, Fontana, Silvia, Horvath, Tamas L., La Cava, Antonio, Matarese, Giuseppe

“…There is a discrepancy between the in vitro anergic state of CD4 +CD25 hiFoxP3 + regulatory T (Treg) cells and their in vivo proliferative capability. The…”
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Metformin restores the mitochondrial network and reverses mitochondrial dysfunction in Down syndrome cells by Izzo, Antonella, Nitti, Maria, Mollo, Nunzia, Paladino, Simona, Procaccini, Claudio, Faicchia, Deriggio, Calì, Gaetano, Genesio, Rita, Bonfiglio, Ferdinando, Cicatiello, Rita, Polishchuk, Elena, Polishchuk, Roman, Pinton, Paolo, Matarese, Giuseppe, Conti, Anna, Nitsch, Lucio

“…Alterations in mitochondrial activity and morphology have been demonstrated in human cells and tissues from individuals with Down syndrome (DS), as well as in…”
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Single systemic transfer of a human gene associated with exceptional longevity halts the progression of atherosclerosis and inflammation in ApoE knockout mice through a CXCR4-mediated mechanism by Puca, Annibale Alessandro, Carrizzo, Albino, Spinelli, Chiara, Damato, Antonio, Ambrosio, Mariateresa, Villa, Francesco, Ferrario, Anna, Maciag, Anna, Fornai, Francesco, Lenzi, Paola, Valenti, Valentina, di Nonno, Flavio, Accarino, Giulio, Madonna, Michele, Forte, Maurizio, Calì, Gaetano, Baragetti, Andrea, Norata, Giuseppe Danilo, Catapano, Alberico Luigi, Cattaneo, Monica, Izzo, Raffaele, Trimarco, Valentina, Montella, Francesco, Versaci, Francesco, Auricchio, Alberto, Frati, Giacomo, Sciarretta, Sebastiano, Madeddu, Paolo, Ciaglia, Elena, Vecchione, Carmine

“…Abstract Aims Here, we aimed to determine the therapeutic effect of longevity-associated variant (LAV)-BPIFB4 gene therapy on atherosclerosis. Methods and…”
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Controlled Release of Doxorubicin for Targeted Chemo-Photothermal Therapy in Breast Cancer HS578T Cells Using Albumin Modified Hybrid Nanocarriers by Carrese, Barbara, Cavallini, Chiara, Sanità, Gennaro, Armanetti, Paolo, Silvestri, Brigida, Calì, Gaetano, Pota, Giulio, Luciani, Giuseppina, Menichetti, Luca, Lamberti, Annalisa

“…Hybrid nanomaterials have attracted research interest owing to their intriguing properties, which may offer new diagnostic options with triggering features,…”
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Regulatory T cells, inflammation, and endoplasmic reticulum stress in women with defective endometrial receptivity by Galgani, Mario, Ph.D, Insabato, Luigi, M.D, Calì, Gaetano, Ph.D, Della Gatta, Anna Nunzia, M.D, Mirra, Paola, Ph.D, Papaccio, Federica, B.Sc, Santopaolo, Marianna, B.Sc, Alviggi, Carlo, M.D, Mollo, Antonio, M.D, Strina, Ida, M.D, Matarese, Giuseppe, M.D, Beguinot, Francesco, M.D, De Placido, Giuseppe, M.D, Ulianich, Luca, Ph.D

“…Objective To investigate immunologic parameters and endoplasmic reticulum (ER) stress associated with unexplained infertility. Design Case-control study…”
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Colchicine reduces platelet aggregation by modulating cytoskeleton rearrangement via inhibition of cofilin and LIM domain kinase 1 by Cimmino, Giovanni, Tarallo, Roberta, Conte, Stefano, Morello, Andrea, Pellegrino, Grazia, Loffredo, Francesco S., Calì, Gaetano, De Luca, Nicola, Golino, Paolo, Trimarco, Bruno, Cirillo, Plinio

“…Platelets activation/aggregation with subsequent thrombus formation is the main event in the pathophysiology of acute coronary syndrome. Once activated,…”
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Oxidized low-density lipoproteins induce tissue factor expression in T-lymphocytes via activation of lectin-like oxidized low-density lipoprotein receptor-1 by Cimmino, Giovanni, Cirillo, Plinio, Conte, Stefano, Pellegrino, Grazia, Barra, Giusi, Maresca, Lucio, Morello, Andrea, Calì, Gaetano, Loffredo, Francesco, De Palma, Raffaele, Arena, Giulia, Sawamura, Tatsuya, Ambrosio, Giuseppe, Golino, Paolo

“…Abstract Aims T-lymphocytes plays an important role in the pathophysiology of acute coronary syndromes. T-cell activation in vitro by pro-inflammatory…”
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NRIP1/RIP140 siRNA-mediated attenuation counteracts mitochondrial dysfunction in Down syndrome by Izzo, Antonella, Manco, Rosanna, Bonfiglio, Ferdinando, Calì, Gaetano, De Cristofaro, Tiziana, Patergnani, Simone, Cicatiello, Rita, Scrima, Rosella, Zannini, Mariastella, Pinton, Paolo, Conti, Anna, Nitsch, Lucio

“…Mitochondrial dysfunction, which is consistently observed in Down syndrome (DS) cells and tissues, might contribute to the severity of the DS phenotype. Our…”
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An immunometabolic pathomechanism for chronic obstructive pulmonary disease by Bruzzaniti, Sara, Bocchino, Marialuisa, Santopaolo, Marianna, Calì, Gaetano, Stanziola, Anna Agnese, D’Amato, Maria, Esposito, Antonella, Barra, Enrica, Garziano, Federica, Micillo, Teresa, Zuchegna, Candida, Romano, Antonella, De Simone, Salvatore, Zuccarelli, Bruno, Mottola, Maria, De Rosa, Veronica, Porcellini, Antonio, Perna, Francesco, Matarese, Giuseppe, Galgani, Mario

“…Chronic obstructive pulmonary disease (COPD) is an inflammatory condition associated with abnormal immune responses, leading to airflow obstruction. Lungs of…”
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Generation and Characterization of a Tumor Stromal Microenvironment and Analysis of Its Interplay with Breast Cancer Cells: An In Vitro Model to Study Breast Cancer-Associated Fibroblast Inactivation by Romano, Veronica, Ruocco, Maria Rosaria, Carotenuto, Pietro, Barbato, Anna, Venuta, Alessandro, Acampora, Vittoria, De Lella, Sabrina, Vigliar, Elena, Iaccarino, Antonino, Troncone, Giancarlo, Calì, Gaetano, Insabato, Luigi, Russo, Daniela, Franco, Brunella, Masone, Stefania, Velotti, Nunzio, Accurso, Antonello, Pellegrino, Tommaso, Fiume, Giuseppe, Belviso, Immacolata, Montagnani, Stefania, Avagliano, Angelica, Arcucci, Alessandro

“…Breast cancer-associated fibroblasts (BCAFs), the most abundant non-cancer stromal cells of the breast tumor microenvironment (TME), dramatically sustain…”
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Genetic Analysis Reveals a Longevity-Associated Protein Modulating Endothelial Function and Angiogenesis by Villa, Francesco, Carrizzo, Albino, Spinelli, Chiara C, Ferrario, Anna, Malovini, Alberto, Maciąg, Anna, Damato, Antonio, Auricchio, Alberto, Spinetti, Gaia, Sangalli, Elena, Dang, Zexu, Madonna, Michele, Ambrosio, Mariateresa, Sitia, Leopoldo, Bigini, Paolo, Calì, Gaetano, Schreiber, Stefan, Perls, Thomas, Fucile, Sergio, Mulas, Francesca, Nebel, Almut, Bellazzi, Riccardo, Madeddu, Paolo, Vecchione, Carmine, Puca, Annibale A

“…RATIONALE:Long living individuals show delay of aging, which is characterized by the progressive loss of cardiovascular homeostasis, along with reduced…”
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Leptin-induced mTOR activation defines a specific molecular and transcriptional signature controlling CD4+ effector T cell responses by Procaccini, Claudio, De Rosa, Veronica, Galgani, Mario, Carbone, Fortunata, Cassano, Silvana, Greco, Dario, Qian, Kui, Auvinen, Petri, Calì, Gaetano, Stallone, Giovanni, Formisano, Luigi, La Cava, Antonio, Matarese, Giuseppe

“…The sensing by T cells of metabolic and energetic changes in the microenvironment can determine the differentiation, maturation, and activation of these cells…”
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Reduced Annexin A1 Expression Associates with Disease Severity and Inflammation in Multiple Sclerosis Patients by Colamatteo, Alessandra, Maggioli, Elisa, Azevedo Loiola, Rodrigo, Hamid Sheikh, Madeeha, Calì, Gaetano, Bruzzese, Dario, Maniscalco, Giorgia Teresa, Centonze, Diego, Buttari, Fabio, Lanzillo, Roberta, Perna, Francesco, Zuccarelli, Bruno, Mottola, Maria, Cassano, Silvana, Galgani, Mario, Solito, Egle, De Rosa, Veronica

“…Chronic neuroinflammation is a key pathological hallmark of multiple sclerosis (MS) that suggests that resolution of inflammation by specialized proresolving…”
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The centrosomal/basal body protein OFD1 is required for microtubule organization and cell cycle progression by Alfieri, Mariaevelina, Iaconis, Daniela, Tammaro, Roberta, Perone, Lucia, Calì, Gaetano, Nitsch, Lucio, Dougherty, Gerard W., Ragnini-Wilson, Antonella, Franco, Brunella

“…•Oral-Facial-Digital type I is due to mutations in the OFD1 gene that encodes a protein localized to centrosomes and basal body of primary cilium.•The loss of…”
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