Search Results - "Calhoun, William J."

Alcoholic lung injury: Metabolic, biochemical and immunological aspects by Kaphalia, Lata, Calhoun, William J.

“…•Ethanol-induced immunosuppression and alcoholic lung disease.•Metabolic basis of alcoholic lung disease.•Ethanol-induced oxidative stress and endoplasmic…”
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Unsupervised phenotyping of Severe Asthma Research Program participants using expanded lung data by Wu, Wei, PhD, Bleecker, Eugene, MD, Moore, Wendy, MD, Busse, William W., MD, Castro, Mario, MD, Chung, Kian Fan, MD, Calhoun, William J., MD, Erzurum, Serpil, MD, Gaston, Benjamin, MD, Israel, Elliot, MD, Curran-Everett, Douglas, PhD, Wenzel, Sally E., MD

“…Background Previous studies have identified asthma phenotypes based on small numbers of clinical, physiologic, or inflammatory characteristics. However, no…”
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Omalizumab in Allergic Bronchopulmonary Aspergillosis: A Systematic Review and Meta-Analysis by Jin, Meiling, Douglass, Jo A., Elborn, J. Stuart, Agarwal, Ritesh, Calhoun, William J., Lazarewicz, Slawomir, Jaumont, Xavier, Yan, Meng

“…An unmet clinical need exists in the management of treatment-refractory allergic bronchopulmonary aspergillosis (ABPA). Omalizumab has shown promising effects…”
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Obesity and asthma: An association modified by age of asthma onset by Holguin, Fernando, MD, MPH, Bleecker, Eugene R., MD, Busse, William W., MD, Calhoun, William J., MD, Castro, Mario, MD, MPH, Erzurum, Serpil C., MD, Fitzpatrick, Anne M., PhD, RN, MS, Gaston, Benjamin, MD, Israel, Elliot, MD, Jarjour, Nizar N., MD, Moore, Wendy C., MD, Peters, Stephen P., MD, Yonas, Michael, DrPH, Teague, W. Gerald, MD, Wenzel, Sally E., MD

“…Background Studies of asthma phenotypes have identified obesity as a component of a group characterized by a high proportion of subjects with adult-onset…”
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Mucosal bromodomain-containing protein 4 mediates aeroallergen-induced inflammation and remodeling by Tian, Bing, Hosoki, Koa, Liu, Zhiqing, Yang, Jun, Zhao, Yingxin, Sun, Hong, Zhou, Jia, Rytting, Erik, Kaphalia, Lata, Calhoun, William J., Sur, Sanjiv, Brasier, Allan R.

“…Frequent exacerbations of allergic asthma lead to airway remodeling and a decrease in pulmonary function, producing morbidity. Cat dander is an aeroallergen…”
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Identification of Asthma Phenotypes Using Cluster Analysis in the Severe Asthma Research Program by Moore, Wendy C, Meyers, Deborah A, Wenzel, Sally E, Teague, W. Gerald, Li, Huashi, Li, Xingnan, D'Agostino, Ralph, Jr, Castro, Mario, Curran-Everett, Douglas, Fitzpatrick, Anne M, Gaston, Benjamin, Jarjour, Nizar N, Sorkness, Ronald, Calhoun, William J, Chung, Kian Fan, Comhair, Suzy A. A, Dweik, Raed A, Israel, Elliot, Peters, Stephen P, Busse, William W, Erzurum, Serpil C, Bleecker, Eugene R, National Heart, Lung, and Blood Institute's Severe Asthma Research Program

“…The Severe Asthma Research Program cohort includes subjects with persistent asthma who have undergone detailed phenotypic characterization. Previous univariate…”
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The new era of add-on asthma treatments: where do we stand? by Calhoun, William J, Chupp, Geoffrey L

“…Globally, a small proportion (5-12%) of asthma patients are estimated to have severe disease. However, severe asthma accounts for disproportionately high…”
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Airway microbiota and bronchial hyperresponsiveness in patients with suboptimally controlled asthma by Huang, Yvonne J., MD, Nelson, Craig E., PhD, Brodie, Eoin L., PhD, DeSantis, Todd Z., MS, Baek, Marshall S., BS, Liu, Jane, MS, Woyke, Tanja, PhD, Allgaier, Martin, PhD, Bristow, Jim, MD, Wiener-Kronish, Jeanine P., MD, Sutherland, E. Rand, MD, MPH, King, Tonya S., PhD, Icitovic, Nikolina, MAS, Martin, Richard J., MD, Calhoun, William J., MD, Castro, Mario, MD, Denlinger, Loren C., MD, PhD, DiMango, Emily, MD, Kraft, Monica, MD, Peters, Stephen P., MD, PhD, Wasserman, Stephen I., MD, Wechsler, Michael E., MD, Boushey, Homer A., MD, Lynch, Susan V., PhD

“…Background Improvement in lung function after macrolide antibiotic therapy has been attributed to reduction in bronchial infection by specific bacteria…”
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Cytokine-Induced Glucocorticoid Resistance from Eosinophil Activation: Protein Phosphatase 5 Modulation of Glucocorticoid Receptor Phosphorylation and Signaling by Pazdrak, Konrad, Straub, Christof, Maroto, Rosario, Stafford, Susan, White, Wendy I, Calhoun, William J, Kurosky, Alexander

“…The mechanisms contributing to persistent eosinophil activation and poor eosinopenic response to glucocorticoids in severe asthma are poorly defined. We…”
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Biologic therapy in the management of asthma by McCracken, Jennifer L, Tripple, Julia W, Calhoun, William J

“…PURPOSE OF REVIEWCurrent asthma management relies on inhaled corticosteroids, but some asthma is not well controlled with inhaled steroids alone or in…”
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An Association between L-Arginine/Asymmetric Dimethyl Arginine Balance, Obesity, and the Age of Asthma Onset Phenotype by HOLGUIN, Fernando, COMHAIR, Suzy A. A, GASTON, Benjamin, ISRAEL, Elliot, JARJOUR, Nizar N, MOORE, Wendy C, PETERS, Stephen P, GERALD TEAGUE, W, KIAN FAN CHUNG, ERZURUM, Serpil C, WENZEL, Sally E, HAZEN, Stanley L, POWERS, Robert W, KHATRI, Sumita S, BLEECKER, Eugene R, BUSSE, William W, CALHOUN, William J, CASTRO, Mario, FITZPATRICK, Anne M

“…Increasing body mass index (BMI) has been associated with less fractional exhaled nitric oxide (Fe(NO)). This may be explained by an increase in the…”
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Asthma exacerbations and lung function in patients with severe or difficult-to-treat asthma by Calhoun, William J., MD, Haselkorn, Tmirah, PhD, Miller, Dave P., MS, Omachi, Theodore A., MD, MBA

“…Patients with exacerbations were more likely to have 3 or more control problems compared with those without exacerbations (41% vs 19%) and less likely to have…”
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Asthma Is More Severe in Older Adults by Zein, Joe G, Dweik, Raed A, Comhair, Suzy A, Bleecker, Eugene R, Moore, Wendy C, Peters, Stephen P, Busse, William W, Jarjour, Nizar N, Calhoun, William J, Castro, Mario, Chung, K Fan, Fitzpatrick, Anne, Israel, Elliot, Teague, W Gerald, Wenzel, Sally E, Love, Thomas E, Gaston, Benjamin M, Erzurum, Serpil C

“…Severe asthma occurs more often in older adult patients. We hypothesized that the greater risk for severe asthma in older individuals is due to aging, and is…”
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Impact of Age and Sex on Outcomes and Hospital Cost of Acute Asthma in the United States, 2011-2012 by Zein, Joe G, Udeh, Belinda L, Teague, W Gerald, Koroukian, Siran M, Schlitz, Nicholas K, Bleecker, Eugene R, Busse, William B, Calhoun, William J, Castro, Mario, Comhair, Suzy A, Fitzpatrick, Anne M, Israel, Elliot, Wenzel, Sally E, Holguin, Fernando, Gaston, Benjamin M, Erzurum, Serpil C

“…Worldwide, asthma is a leading cause of morbidity, mortality and economic burden, with significant gender and racial disparities. However, little attention has…”
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Race is associated with differences in airway inflammation in patients with asthma by Nyenhuis, Sharmilee M., MD, Krishnan, Jerry A., MD, PhD, Berry, Alalia, MD, Calhoun, William J., MD, Chinchilli, Vernon M., PhD, Engle, Linda, BS, Grossman, Nicole, MD, Holguin, Fernando, MD, MPH, Israel, Elliot, MD, Kittles, Rick A., PhD, Kraft, Monica, MD, Lazarus, Stephen C., MD, Lehman, Erik B., MS, Mauger, David T., PhD, Moy, James N., MD, Peters, Stephen P., MD, PhD, Phipatanakul, Wanda, MD, MS, Smith, Lewis J., MD, Sumino, Kaharu, MD, MPH, Szefler, Stanley J., MD, Wechsler, Michael E., MD, MMSc, Wenzel, Sally, MD, White, Steven R., MD, Ackerman, Steven J., PhD

“…Background African American subjects have a greater burden from asthma compared with white subjects. Whether the pattern of airway inflammation differs between…”
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Clinical Implications of Having Reduced Mid Forced Expiratory Flow Rates (FEF25-75), Independently of FEV1, in Adult Patients with Asthma by Riley, Craig M, Wenzel, Sally E, Castro, Mario, Erzurum, Serpil C, Chung, Kian Fan, Fitzpatrick, Anne M, Gaston, Benjamin, Israel, Elliot, Moore, Wendy C, Bleecker, Eugene R, Calhoun, William J, Jarjour, Nizar N, Busse, William W, Peters, Stephen P, Teague, W Gerald, Sorkness, Ronald, Holguin, Fernando

“…FEF25-75 is one of the standard results provided in spirometry reports; however, in adult asthmatics there is limited information on how this physiological…”
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A Comprehensive Analysis of the Stability of Blood Eosinophil Levels by Chipps, Bradley E, Jarjour, Nizar, Calhoun, William J, Iqbal, Ahmar, Haselkorn, Tmirah, Yang, Ming, Brumm, Jochen, Corren, Jonathan, Holweg, Cecile T J, Bafadhel, Mona

“…Blood eosinophil counts are used to inform diagnosis/management of eosinophilic asthma. Examine blood eosinophil variability and identify factors affecting…”
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Identification of steroid response signature among patients with mild to moderate asthma using differential protein expression analysis by Patel, Tanvi, MD, Kaphalia, Lata, MS, MEd, PhD, Calhoun, William J., MD

“…Conclusions Except for IL-8, pro-inflammatory cytokine expression was decreased in A-S and A+S, compared to the N group…”
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Molecular phenotyping of severe asthma using pattern recognition of bronchoalveolar lavage–derived cytokines by Brasier, Allan R., MD, Victor, Sundar, MS, Boetticher, Gary, PhD, Ju, Hyunsu, PhD, Lee, Chang, MS, Bleecker, Eugene R., MD, Castro, Mario, MD, Busse, William W., MD, Calhoun, William J., MD

“…Background Asthma is a heterogeneous clinical disorder. Methods for objective identification of disease subtypes will focus on clinical interventions and help…”
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Ethanol metabolism, oxidative stress, and endoplasmic reticulum stress responses in the lungs of hepatic alcohol dehydrogenase deficient deer mice after chronic ethanol feeding by Kaphalia, Lata, Boroumand, Nahal, Hyunsu, Ju, Kaphalia, Bhupendra S., Calhoun, William J.

“…Consumption and over-consumption of alcoholic beverages are well-recognized contributors to a variety of pulmonary disorders, even in the absence of…”
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