Search Results - "Calenda, Charles"

Dysregulated Autophagy and Lysosome Function Are Linked to Exosome Production by Micro‐RNA 155 in Alcoholic Liver Disease by Babuta, Mrigya, Furi, Istvan, Bala, Shashi, Bukong, Terence N., Lowe, Patrick, Catalano, Donna, Calenda, Charles, Kodys, Karen, Szabo, Gyongyi

“…Cellular homeostais, that is normally maintained through autophagy, is disrupted in alcoholic liver disease (ALD). Because autophagy and exosome biogenesis…”
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Endoplasmic Reticulum Stress-induced Hepatocellular Death Pathways Mediate Liver Injury and Fibrosis via Stimulator of Interferon Genes by Iracheta-Vellve, Arvin, Petrasek, Jan, Gyongyosi, Benedek, Satishchandran, Abhishek, Lowe, Patrick, Kodys, Karen, Catalano, Donna, Calenda, Charles D., Kurt-Jones, Evelyn A., Fitzgerald, Katherine A., Szabo, Gyongyi

“…Fibrosis, driven by inflammation, marks the transition from benign to progressive stages of chronic liver diseases. Although inflammation promotes…”
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Steatosis, inflammasome upregulation, and fibrosis are attenuated in miR-155 deficient mice in a high fat-cholesterol-sugar diet-induced model of NASH by Bala, Shashi, Ganz, Michal, Babuta, Mrigya, Zhuang, Yuan, Csak, Timea, Calenda, Charles D., Szabo, Gyongyi

“…Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease globally. miRNAs (miRs) regulate various cellular events that lead…”
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FXR and TGR5 Agonists Ameliorate Liver Injury, Steatosis, and Inflammation After Binge or Prolonged Alcohol Feeding in Mice by Iracheta‐Vellve, Arvin, Calenda, Charles D., Petrasek, Jan, Ambade, Aditya, Kodys, Karen, Adorini, Luciano, Szabo, Gyongyi

“…Bile acids (BAs) activate various dedicated receptors, including the farnesoid X receptor (FXR) and the Takeda G protein‐coupled receptor 5 (TGR5). The FXR…”
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Alcohol-induced extracellular ASC specks perpetuate liver inflammation and damage in alcohol-associated hepatitis even after alcohol cessation by de Carvalho Ribeiro, Marcelle, Iracheta-Vellve, Arvin, Babuta, Mrigya, Calenda, Charles D, Copeland, Christopher, Zhuang, Yuan, Lowe, Patrick P, Hawryluk, Danielle, Catalano, Donna, Cho, Yeonhee, Barton, Bruce, Dasarathy, Srinivasan, McClain, Craig, McCullough, Arthur J, Mitchell, Mack C, Nagy, Laura E, Radaeva, Svetlana, Lien, Egil, Golenbock, Douglas T, Szabo, Gyongyi

“…Prolonged systemic inflammation contributes to poor clinical outcomes in severe alcohol-associated hepatitis (AH) even after the cessation of alcohol use…”
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Acute Kidney Injury in a Previously Healthy 56-Year-Old Male Following a Direct Visual Internal Urethrotomy of a Bulbar Stricture by Calenda, Charles D, Toohey, Cameron R, Levy, Madeline, Vanmali, Nisha, Ubhi, Jaspreet, Ishak, Noshi, Marshall, Stephen D

“…Acute kidney injury (AKI) is a frequent finding in acutely ill and hospitalized patients arising from various etiologies. Anuric AKI, a more pronounced form of…”
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Pneumatosis Intestinalis, Pneumoperitoneum, Pneumoretroperitoneum, Pneumomediastinum, and Pneumobilia After Pembrolizumab Therapy: A Case Report by Calenda, Charles D, Toohey, Cameron R, Levy, Madeline, Bhardwaj, AyJy, Ubhi, Jaspreet, Sharma, Arunima, Abou Rizk, Fady

“…Immune checkpoint inhibitors (ICIs) are becoming increasingly popular in treating cancers resistant to traditional chemotherapy. While ICIs have shown promise…”
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Deficiency of miR‐208a Exacerbates CCl4‐Induced Acute Liver Injury in Mice by Activating Cell Death Pathways by Bala, Shashi, Calenda, Charles D., Catalano, Donna, Babuta, Mrigya, Kodys, Karen, Nasser, Imad A., Vidal, Barbara, Szabo, Gyongyi

“…Acute liver injury (ALI) is associated with multiple cellular events such as necrosis, apoptosis, oxidative stress and inflammation, which can lead to liver…”
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Pharmacological Inhibition of CCR2/5 Signaling Prevents and Reverses Alcohol‐Induced Liver Damage, Steatosis, and Inflammation in Mice by Ambade, Aditya, Lowe, Patrick, Kodys, Karen, Catalano, Donna, Gyongyosi, Benedek, Cho, Yeonhee, Iracheta‐Vellve, Arvin, Adejumo, Adeyinka, Saha, Banishree, Calenda, Charles, Mehta, Jeeval, Lefebvre, Eric, Vig, Pamela, Szabo, Gyongyi

“…Kupffer cell and macrophage (MØ) activation contributes to steatosis, inflammation, and fibrosis in alcoholic liver disease (ALD). We found increased frequency…”
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Neutrophil extracellular traps activate hepatic stellate cells and monocytes via NLRP3 sensing in alcohol-induced acceleration of MASH fibrosis by Babuta, Mrigya, Morel, Caroline, de Carvalho Ribeiro, Marcelle, Calenda, Charles, Ortega-Ribera, Martí, Thevkar Nagesh, Prashanth, Copeland, Christopher, Zhuang, Yuan, Wang, Yanbo, Cho, Yeonhee, Joshi, Radhika, Brezani, Viliam, Hawryluk, Danielle, Datta, Aditi Ashish, Mehta, Jeeval, Nasser, Imad, Szabo, Gyongyi

“…Alcohol use in metabolic dysfunction-associated steatohepatitis (MASH) is associated with an increased risk of fibrosis and liver-related death. Here, we aimed…”
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Sa1500 – Alcohol Induced Il-17A Production in Paneth Cells Amplifies Endoplasmic Reticulum Stress and Inflammasome-Il-18 Activation in the Proximal Small Intestine in Mice by Cho, Yeonhee, Lowe, Patrick, Gyöngyösi, Benedek, Calenda, Charles D., Iracheta-Vellve, Arvin, Satishchandran, Abhishek, Ambade, Aditya, Szabo, Gyongyi

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A novel experimental model of MetALD in male mice recapitulates key features of severe alcohol-associated hepatitis by Babuta, Mrigya, Morel, Caroline, de Carvalho Ribeiro, Marcelle, Datta, Aditi Ashish, Calenda, Charles, Copeland, Christopher, Nasser, Imad, Szabo, Gyongyi

“…The recent increase in the incidence of alcohol-associated hepatitis (AH) coincides with the obesity epidemic in the United States. However, current mouse…”
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Deficiency of miR-208a Exacerbates CCl 4 -Induced Acute Liver Injury in Mice by Activating Cell Death Pathways by Bala, Shashi, Calenda, Charles D, Catalano, Donna, Babuta, Mrigya, Kodys, Karen, Nasser, Imad A, Vidal, Barbara, Szabo, Gyongyi

“…Acute liver injury (ALI) is associated with multiple cellular events such as necrosis, apoptosis, oxidative stress and inflammation, which can lead to liver…”
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Pneumatosis Intestinalis, Pneumoperitoneum, Pneumoretroperitoneum, Pneumomediastinum, and Pneumobilia After Pembrolizumab Therapy: A Case Report by Calenda, Charles D, Toohey, Cameron R, Levy, Madeline, Bhardwaj, AyJy, Ubhi, Jaspreet, Sharma, Arunima, Abou Rizk, Fady

“…Immune checkpoint inhibitors (ICIs) are becoming increasingly popular in treating cancers resistant to traditional chemotherapy. While ICIs have shown promise…”
Get full text