Search Results - "Caleb, G."

Evaluation of Aducanumab for Alzheimer Disease: Scientific Evidence and Regulatory Review Involving Efficacy, Safety, and Futility by Alexander, G. Caleb, Emerson, Scott, Kesselheim, Aaron S

“…This Viewpoint details the development and regulatory path of aducanumab, a human IgG1 monoclonal antibody to treat Alzheimer disease, including termination of…”
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National Trends in Ambulatory Oral Anticoagulant Use by Barnes, Geoffrey D., MD, MSc, Lucas, Eleanor, BA, Alexander, G. Caleb, MD, MS, Goldberger, Zachary D., MD, MS

“…Abstract Background Four direct oral anticoagulants (DOACs) have been brought to market for the treatment of nonvalvular atrial fibrillation and venous…”
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Patterns of Buprenorphine-Naloxone Treatment for Opioid Use Disorder in a Multistate Population by Saloner, Brendan, Daubresse, Matthew, Alexander, G. Caleb

“…Buprenorphine-naloxone treatment for opioid use disorder has rapidly expanded, yet little is known about treatment outcomes among patients in the general…”
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An Epidemic in the Midst of a Pandemic: Opioid Use Disorder and COVID-19 by Alexander, G Caleb, Stoller, Kenneth B, Haffajee, Rebecca L, Saloner, Brendan

“…The COVID-19 pandemic is a particularly grave risk to the millions of Americans with opioid use disorder, who—already vulnerable and marginalized—are heavily…”
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Ensuring Access to Medications in the US During the COVID-19 Pandemic by Alexander, G. Caleb, Qato, Dima M

“…This Viewpoint proposes strategies to ensure adequate supply and distribution of medication in the US during and beyond the coronavirus pandemic, including…”
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Changes in Prescription and Over-the-Counter Medication and Dietary Supplement Use Among Older Adults in the United States, 2005 vs 2011 by Qato, Dima M, Wilder, Jocelyn, Schumm, L Philip, Gillet, Victoria, Alexander, G Caleb

“…Prescription and over-the-counter medicines and dietary supplements are commonly used, alone and together, among older adults. However, the effect of recent…”
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The Problem of Aducanumab for the Treatment of Alzheimer Disease by Alexander, G. Caleb, Karlawish, Jason

“…Approval by the FDA comes with a drug label. The many pages of carefully composed text that explain the drug's indications, use, dosing, and other properties…”
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Association between sodium-glucose cotransporter 2 (SGLT2) inhibitors and lower extremity amputation: A systematic review and meta-analysis by Heyward, James, Mansour, Omar, Olson, Lily, Singh, Sonal, Alexander, G Caleb

“…The association between sodium-glucose cotransporter 2 inhibitors (SGLT2i's) and lower extremity amputation is unclear. To systematically review randomized…”
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National Trends in Oral Anticoagulant Use in the United States, 2007 to 2011 by KIRLEY, Kate, QATO, Dima M, KORNFIELD, Rachel, STAFFORD, Randall S, CALEB ALEXANDER, G

“…Little is known regarding the adoption of direct thrombin inhibitors in clinical practice. We examine trends in oral anticoagulation for the prevention of…”
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Use and Content of Primary Care Office-Based vs Telemedicine Care Visits During the COVID-19 Pandemic in the US by Alexander, G Caleb, Tajanlangit, Matthew, Heyward, James, Mansour, Omar, Qato, Dima M, Stafford, Randall S

“…Little is known about the association between the coronavirus disease 2019 (COVID-19) pandemic and the level and content of primary care delivery in the US. To…”
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Association Between Sodium-Glucose Cotransporter 2 Inhibitors and Lower Extremity Amputation Among Patients With Type 2 Diabetes by Chang, Hsien-Yen, Singh, Sonal, Mansour, Omar, Baksh, Sheriza, Alexander, G Caleb

“…Results of clinical trials suggest that canagliflozin, a sodium-glucose cotransporter 2 (SGLT-2) inhibitor for treating type 2 diabetes, may be associated with…”
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The availability of pharmacies in the United States: 2007-2015 by Qato, Dima Mazen, Zenk, Shannon, Wilder, Jocelyn, Harrington, Rachel, Gaskin, Darrell, Alexander, G Caleb

“…Despite their increasingly important role in health care delivery, little is known about the availability, and characteristics, of community pharmacies in the…”
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Prescription Opioid Analgesics Commonly Unused After Surgery: A Systematic Review by Bicket, Mark C, Long, Jane J, Pronovost, Peter J, Alexander, G Caleb, Wu, Christopher L

“…Prescription opioid analgesics play an important role in the treatment of postoperative pain; however, unused opioids may be diverted for nonmedical use and…”
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Fentanyl and fentanyl analogs in the illicit stimulant supply: Results from U.S. drug seizure data, 2011–2016 by Park, Ju Nyeong, Rashidi, Emaan, Foti, Kathryn, Zoorob, Michael, Sherman, Susan, Alexander, G. Caleb

“…•Fentanyl-stimulant combinations increased between 2015 and 2016 in the U.S.•The number and proportion of fentanyl-stimulant combinations varied by…”
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Effect of Adherence to Oral Anticoagulants on Risk of Stroke and Major Bleeding Among Patients With Atrial Fibrillation by Yao, Xiaoxi, Abraham, Neena S., Alexander, G. Caleb, Crown, William, Montori, Victor M., Sangaralingham, Lindsey R., Gersh, Bernard J., Shah, Nilay D., Noseworthy, Peter A.

“…Background In comparison to warfarin, non–vitamin K antagonist oral anticoagulants (NOACs) have the advantages of ease of dosing, fewer drug interactions, and…”
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Distribution of Abatement Funds Arising From US Opioid Litigation by Alexander, G. Caleb, Mansour, Omar

“…This Viewpoint discusses the settlement agreements reached against several major pharmaceutical distributors resulting from the US opioid epidemic and how…”
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Most primary care physicians are aware of prescription drug monitoring programs, but many find the data difficult to access by Rutkow, Lainie, Turner, Lydia, Lucas, Eleanor, Hwang, Catherine, Alexander, G Caleb

“…State prescription drug monitoring programs are common tools intended to reduce prescription drug abuse and diversion, or the nonmedical use of a prescribed…”
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Ambulatory Treatment of Type 2 Diabetes in the U.S., 1997-2012 by TURNER, Lydia W, NARTEY, David, STAFFORD, Randall S, SINGH, Sonal, CALEB ALEXANDER, G

“…OBJECTIVE Type 2 diabetes is increasingly common and associated with substantial morbidity and mortality. This study examines trends in the patterns and costs…”
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Rejection of Aducanumab (Aduhelm) by the Health Care Community: Lessons Learned and the Path Ahead by Bauchner, Howard, Alexander, G. Caleb

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The Evolving Overdose Epidemic: Synthetic Opioids and Rising Stimulant-Related Harms by Jones, Christopher M, Bekheet, Faraah, Park, Ju Nyeong, Alexander, G Caleb

“…Abstract The opioid overdose epidemic is typically described as having occurred in 3 waves, with morbidity and mortality accruing over time principally from…”
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