Relationship between asthma and cognition: the Cooper Center Longitudinal Study

Relationship between asthma and cognition: the Cooper Center Longitudinal Study

Background Minimal data are available on the relationship between asthma and cognitive performance. In this report, we examine the relationship between asthma and cognitive performance in older adults, a subpopulation with elevated risk of cognitive impairment. Methods We conducted a cross‐sectional...

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Bibliographic Details
Published in:Allergy (Copenhagen) Vol. 68; no. 4; pp. 545 - 548
Main Authors: Caldera‐Alvarado, G., Khan, D. A., DeFina, L. F., Pieper, A., Brown, E. S.
Format: Journal Article
Language:English
Published: Denmark Blackwell Publishing Ltd 01-04-2013
Subjects:
Age
Aged
Aged, 80 and over
Asthma
Asthma - complications
Asthma - diagnosis
Asthma - drug therapy
cognition
Cognitive ability
Cognitive Dysfunction - complications
Cognitive Dysfunction - diagnosis
Corticoids
corticosteroid
Cross-Sectional Studies
Data processing
Demography
elderly
Female
Humans
Longitudinal Studies
Male
Middle Aged
Neuropsychological Tests
Older people
Retrospective Studies
Risk Factors
spirometry
Subpopulations
Texas
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Summary:Background Minimal data are available on the relationship between asthma and cognitive performance. In this report, we examine the relationship between asthma and cognitive performance in older adults, a subpopulation with elevated risk of cognitive impairment. Methods We conducted a cross‐sectional, retrospective analysis of 1380 participants age ≥55 who completed preventive health examinations at the Cooper Clinic in Dallas, TX. Cognition was assessed using the Montreal Cognitive Assessment (MoCA), a brief test for mild cognitive impairment. Data were analyzed in a multiple logistic regression using MoCA scores suggestive of cognitive impairment as the dependent variable. Results When controlling for demographic characteristics, self‐rated health status, inhaled corticosteroid use, and FEV1/FVC, asthma were associated with 78% increased risk of cognitive impairment (P = 0.02) as defined by MoCA score. Conclusions In the largest sample examined to date, we have identified a significant relationship between asthma and cognitive impairment in older people.
Bibliography:Edited by: Marek Sanak
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ISSN:0105-4538
1398-9995
DOI:10.1111/all.12125