Search Results - "Calderón‐Montaño, José Manuel"

Pro-oxidant natural products as anticancer agents by Martin-Cordero, Carmen, Leon-Gonzalez, Antonio Jose, Calderon-Montano, Jose Manuel, Burgos-Moron, Estefania, Lopez-Lazaro, Miguel

“…Cancer cells produce high levels of reactive oxygen species (ROS) that lead to a state of increased basal oxidative stress. Since this state of oxidative…”
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The Coffee Constituent Chlorogenic Acid Induces Cellular DNA Damage and Formation of Topoisomerase I– and II–DNA Complexes in Cells by Burgos-Morón, Estefanía, Calderón-Montaño, José Manuel, Orta, Manuel Luis, Pastor, Nuria, Pérez-Guerrero, Concepción, Austin, Caroline, Mateos, Santiago, López-Lázaro, Miguel

“…Chlorogenic acid (CGA) is a plant polyphenol with known antioxidant properties. Although some studies suggest that CGA has anticancer properties, others…”
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Evaluating the Cancer Therapeutic Potential of Cardiac Glycosides by Burgos-Morón, Estefanía, Calderón-Montaño, José Manuel, Orta, Manuel Luis, Maldonado-Navas, Dolores, García-Domínguez, Irene, López-Lázaro, Miguel

“…Cardiac glycosides, also known as cardiotonic steroids, are a group of natural products that share a steroid-like structure with an unsaturated lactone ring…”
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Cancer-Specific Synthetic Lethality between ATR and CHK1 Kinase Activities by Sanjiv, Kumar, Hagenkort, Anna, Calderón-Montaño, José Manuel, Koolmeister, Tobias, Reaper, Philip M., Mortusewicz, Oliver, Jacques, Sylvain A., Kuiper, Raoul V., Schultz, Niklas, Scobie, Martin, Charlton, Peter A., Pollard, John R., Berglund, Ulrika Warpman, Altun, Mikael, Helleday, Thomas

“…ATR and CHK1 maintain cancer cell survival under replication stress and inhibitors of both kinases are currently undergoing clinical trials. As ATR activity is…”
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Sulforaphane homologues: Enantiodivergent synthesis of both enantiomers, activation of the Nrf2 transcription factor and selective cytotoxic activity by Elhalem, Eleonora, Recio, Rocío, Werner, Sabine, Lieder, Franziska, Calderón-Montaño, José Manuel, López-Lázaro, Miguel, Fernández, Inmaculada, Khiar, Noureddine

“…Reported is an enantiodivergent approach for the synthesis of both enantiomers of sulforaphane (SFN) homologues with different chain lengths between the…”
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The dark side of curcumin by Burgos‐Morón, Estefanía, Calderón‐Montaño, José Manuel, Salvador, Javier, Robles, Antonio, López‐Lázaro, Miguel

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Selective cytotoxic activity and DNA damage by an epoxyalkyl galactopyranoside by Burgos‐Morón, Estefanía, Pastor, Nuria, Orta, Manuel Luis, Jiménez‐Alonso, Julio José, Vega‐Holm, Margarita, Vega‐Pérez, José Manuel, Iglesias‐Guerra, Fernando, Mateos, Santiago, López‐Lázaro, Miguel, Calderón‐Montaño, José Manuel

“…Preclinical Research & Development Several clinically useful anticancer drugs selectively kill cancer cells by inducing DNA damage; the genomic instability and…”
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Cells Deficient in the Fanconi Anemia Protein FANCD2 are Hypersensitive to the Cytotoxicity and DNA Damage Induced by Coffee and Caffeic Acid by Burgos-Morón, Estefanía, Calderón-Montaño, José Manuel, Orta, Manuel Luis, Guillén-Mancina, Emilio, Mateos, Santiago, López-Lázaro, Miguel

“…Epidemiological studies have found a positive association between coffee consumption and a lower risk of cardiovascular disorders, some cancers, diabetes,…”
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Carbohydrate-Based NK1R Antagonists with Broad-Spectrum Anticancer Activity by Recio, Rocío, Lerena, Patricia, Pozo, Esther, Calderón-Montaño, José Manuel, Burgos-Morón, Estefanía, López-Lázaro, Miguel, Valdivia, Victoria, Pernia Leal, Manuel, Mouillac, Bernard, Organero, Juan Ángel, Khiar, Noureddine, Fernández, Inmaculada

“…NK1R antagonists, investigated for the treatment of several pathologies, have shown encouraging results in the treatment of several cancers. In the present…”
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Manipulation of Amino Acid Levels with Artificial Diets Induces a Marked Anticancer Activity in Mice with Renal Cell Carcinoma by Calderón-Montaño, José Manuel, Guillén-Mancina, Emilio, Jiménez-Alonso, Julio José, Jiménez-González, Víctor, Burgos-Morón, Estefanía, Mate, Alfonso, Pérez-Guerrero, María Concepción, López-Lázaro, Miguel

“…Targeted therapies with antiangiogenic drugs (e.g., sunitinib) and immune checkpoint inhibitors (e.g., anti-PD-1 antibodies) are the standard of care for…”
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Artificial Diets with Altered Levels of Sulfur Amino Acids Induce Anticancer Activity in Mice with Metastatic Colon Cancer, Ovarian Cancer and Renal Cell Carcinoma by Jiménez-Alonso, Julio José, Guillén-Mancina, Emilio, Calderón-Montaño, José Manuel, Jiménez-González, Víctor, Díaz-Ortega, Patricia, Burgos-Morón, Estefanía, López-Lázaro, Miguel

“…Sulfur-containing amino acids methionine (Met), cysteine (Cys) and taurine (Tau) are common dietary constituents with important cellular roles. Met restriction…”
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Repurposing Study of 4-Acyl-1-phenylaminocarbonyl-2-substituted-piperazine Derivatives as Potential Anticancer Agents-In Vitro Evaluation against Breast Cancer Cells by Guillén-Mancina, Emilio, García-Lozano, María Del Rosario, Burgos-Morón, Estefanía, Mazzotta, Sarah, Martínez-Aguado, Pablo, Calderón-Montaño, José Manuel, Vega-Pérez, José Manuel, López-Lázaro, Miguel, Iglesias-Guerra, Fernando, Vega-Holm, Margarita

“…Breast cancer is the most common type of cancer in women. Although current treatments can increase patient survival, they are rarely curative when the disease…”
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A Diet Lacking Selenium, but Not Zinc, Copper or Manganese, Induces Anticancer Activity in Mice with Metastatic Cancers by Díaz-Ortega, Patricia, Calderón-Montaño, José Manuel, Jiménez-Alonso, Julio José, Guillén-Mancina, Emilio, Jiménez-González, Víctor, Burgos-Morón, Estefanía, López-Lázaro, Miguel

“…Selenium, zinc, copper, and manganese are essential components of antioxidant enzymes involved in the elimination of reactive oxygen species (ROS). Given that…”
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Artificial Diets Based on Selective Amino Acid Restriction versus Capecitabine in Mice with Metastatic Colon Cancer by Jiménez-Alonso, Julio José, Guillén-Mancina, Emilio, Calderón-Montaño, José Manuel, Jiménez-González, Víctor, Díaz-Ortega, Patricia, Burgos-Morón, Estefanía, López-Lázaro, Miguel

“…New therapies are needed to improve the low survival rates of patients with metastatic colon cancer. Evidence suggests that amino acid (AA) restriction can be…”
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Screening for Selective Anticancer Activity of 65 Extracts of Plants Collected in Western Andalusia, Spain by Calderón-Montaño, José Manuel, Martínez-Sánchez, Sara María, Jiménez-González, Víctor, Burgos-Morón, Estefanía, Guillén-Mancina, Emilio, Jiménez-Alonso, Julio José, Díaz-Ortega, Patricia, García, Felipe, Aparicio, Abelardo, López-Lázaro, Miguel

“…Finding cytotoxic drugs with a high selectivity towards cancer cells is crucial to improve the low survival rates of patients diagnosed with metastatic…”
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Cholesterol Levels Affect the Performance of AuNPs-Decorated Thermo-Sensitive Liposomes as Nanocarriers for Controlled Doxorubicin Delivery by García, Mónica C., Naitlho, Nabila, Calderón-Montaño, José Manuel, Drago, Estrella, Rueda, Manuela, Longhi, Marcela, Rabasco, Antonio M., López-Lázaro, Miguel, Prieto-Dapena, Francisco, González-Rodríguez, María Luisa

“…Stimulus-responsive liposomes (L) for triggering drug release to the target site are particularly useful in cancer therapy. This research was focused on the…”
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Cancer-Specific Synthetic Lethality between ATR and CHK1 Kinase Activities by Sanjiv, Kumar, Hagenkort, Anna, Calderón-Montaño, José Manuel, Koolmeister, Tobias, Reaper, Philip M., Mortusewicz, Oliver, Jacques, Sylvain A., Kuiper, Raoul V., Schultz, Niklas, Scobie, Martin, Charlton, Peter A., Pollard, John R., Berglund, Ulrika Warpman, Altun, Mikael, Helleday, Thomas

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Overexpressed c-Myc Sensitizes Cells to TH1579, a Mitotic Arrest and Oxidative DNA Damage Inducer by Henriksson, Sofia, Calderón-Montaño, José Manuel, Solvie, Daniel, Warpman Berglund, Ulrika, Helleday, Thomas

“…Previously, we reported that MTH1 inhibitors TH588 and TH1579 selectively induce oxidative damage and kill Ras-expressing or -transforming cancer cells, as…”
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Evaluation of Anticancer Activity of 76 Plant Species Collected in Andalusia (Spain) against Lung Cancer Cells by Jiménez-González, Víctor, Benítez, Guillermo, Pastor, Julio Enrique, López-Lázaro, Miguel, Calderón-Montaño, José Manuel

“…Every year, cancer kills millions of people around the world. Finding more selective anticancer agents is essential to improve the low survival rates of…”
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Identification of Triazolothiadiazoles as Potent Inhibitors of the dCTP Pyrophosphatase 1 by Llona-Minguez, Sabin, Höglund, Andreas, Wiita, Elisee, Almlöf, Ingrid, Mateus, André, Calderón-Montaño, José Manuel, Cazares-Körner, Cindy, Homan, Evert, Loseva, Olga, Baranczewski, Pawel, Jemth, Ann-Sofie, Häggblad, Maria, Martens, Ulf, Lundgren, Bo, Artursson, Per, Lundbäck, Thomas, Jenmalm Jensen, Annika, Warpman Berglund, Ulrika, Scobie, Martin, Helleday, Thomas

“…The dCTP pyrophosphatase 1 (dCTPase) is involved in the regulation of the cellular dNTP pool and has been linked to cancer progression. Here we report on the…”
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